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LEF1 regulated CTHRC1 promotes silica-induced pulmonary fibrosis through CD44-dependent signaling

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Silicosis is an incurable fibrotic lung disease caused by crystalline silica exposure. Aberrant activation of lung fibroblasts into pathological fibroblasts is a hallmark of silicosis. CTHRC1 has been considered a novel fibroblast activation biomarker. This st... ...