Interaction of venlafaxine and its major metabolite O-desmethylvenlafaxine with phosphatidylcholine bilayer [0.03%]
文拉法辛及其主要代谢产物O-去甲基文拉法辛与卵磷脂双层膜的相互作用
Thinh T Q Le,Dat N T Ngo,Tho H Ho et al.
Thinh T Q Le et al.
Venlafaxine (VLX) and its active metabolite O-desmethylvenlafaxine (ODV) must partition into lipid membranes before reaching their membrane-embedded transporter targets. The principal active metabolite, ODV, differs from VLX by the removal ...
Fluorescence readouts of KL4-induced changes in lipid order and fluidity in surfactant-like bilayers relevant to ARDS and COVID-19 lung injury [0.03%]
与ARDS和COVID-19肺损伤相关的表面活性剂样双层中KL4诱导的脂质顺序和流动性的荧光读数
Otonye Braide-Moncoeur,Nhi Tran,Michelle Yi et al.
Otonye Braide-Moncoeur et al.
KL4, a 21-residue mimetic of the C-terminus of surfactant protein B, is effective in treating infant respiratory distress syndrome (RDS). It works by reducing alveolar surface tension and improving oxygen exchange. Here, we use steady-state...
Consequences of defective mitochondrial protein import: From targeting signals to pathology [0.03%]
缺陷的线粒体蛋白质导入的后果：从靶向信号到病理学
Maya Cielo Cornejo,Sandy Che-Eun S Lee,Shaya Smith et al.
Maya Cielo Cornejo et al.
Cellular organelles are uniquely specialized membrane-bound structures that enable cells to organize and coordinate biochemical processes. Specifically, mitochondria are essential organelles for cellular metabolism, coordinating energy prod...
The ESCRT pathway and HIV-1 budding: A paradigm of viral exploitation of cellular regulation [0.03%]
ESCRT途径与HIV-1出芽：病毒利用细胞调控的典范
Mahmoud M Yaseen,Nizar M Abuharfeil
Mahmoud M Yaseen
The ESCRT (Endosomal Sorting Complexes Required for Transport) pathway is a conserved cellular machinery essential for reverse-topology membrane fission events, such as multivesicular body biogenesis and cytokinesis. Human Immunodeficiency ...
Bigger isn't always better: Comparing system size, hydration, and software for lipid membrane analysis [0.03%]
bigger isn't always better：比较系统大小、水化和脂质膜分析软件
F Carvalho,P Maximiano,P N Simões et al.
F Carvalho et al.
The structural and dynamic properties of lipid membranes vary with bilayer size and hydration. While Molecular Dynamics (MD) simulations are a powerful tool for studying cellular membranes, results can be sensitive to the analysis workflow ...
Nanoclusters of small amphiphilic molecules in a raft-mimicking model membrane [0.03%]
小两亲分子纳米聚集体在仿脂筏模型膜中的形成
Anna S Kashnik,Denis S Baranov,Sergei A Dzuba
Anna S Kashnik
Biological membranes are considered as laterally heterogeneous, containing disordered and ordered regions ranging in size from a few nanometers to micrometers. Pulsed dipolar EPR spectroscopy (PDS) is specifically designed to determine dist...
Membrane structural properties in Staphylococcus aureus are tuned by the carotenoid 4,4'-diaponeurosporenoic acid [0.03%]
金黄色葡萄球菌中的类胡萝卜素4，4'-二脱氢神经孢绿素可调节细胞膜结构属性
Jessica Múnera-Jaramillo,Gerson-Dirceu López,Elizabeth Suesca et al.
Jessica Múnera-Jaramillo et al.
Staphylococcus aureus (S. aureus) is a clinically relevant pathogen capable of adapting its membrane composition in response to environmental stress. In this adaptive process, bacterial carotenoids play a crucial role. Although staphyloxant...
Thermotropic and barotropic phase behavior of phospholipid bilayers: A thermodynamic phase-diagram perspective incorporating modular lipid architecture [0.03%]
基于模块化脂质结构的热变性和压强依赖相行为：从热力学相图角度理解磷脂双分子层
Nobutake Tamai,Masaki Goto,Hitoshi Matsuki
Nobutake Tamai
Understanding how lipid bilayer phase behavior responds to temperature and pressure is essential for elucidating membrane stability and adaptability under diverse environmental conditions. In this review, thermotropic and barotropic phase b...
Full-length SARS-CoV-2 envelope protein adopts an interfacial topology in lipid bilayers [0.03%]
全长的SARS-CoV-2包膜蛋白在脂质双层上采用界面构象
Andrew K Morris,Luke Wardrip,Indra Dev Sahu et al.
Andrew K Morris et al.
The envelope protein is essential for the replication of coronaviruses. Several structures of the envelope protein of the SARS-CoV-2 and the closely related SARS viruses are available. However, an experimental structure of the entire full-l...
Heparin interactions with phospholipid and cholesterol monolayers mimicking SARS-CoV-2 envelope and host membranes: A Langmuir film approach [0.03%]
肝素与模拟SARS-CoV-2包膜和宿主膜的磷脂和胆固醇单分子层的相互作用：Langmuir薄膜研究方法
Pedro V Pantarotto,Kevin F Dos Santos,Ana Luiza T Silva et al.
Pedro V Pantarotto et al.
Understanding how heparin modulates membrane interactions relevant to SARS-CoV-2 entry is essential for elucidating its antiviral mechanisms. Here, Langmuir monolayers were used as biomimetic models of viral and host membranes to investigat...