Differential lipid dynamics regulation by sterols in ceramide and sphingomyelin containing membranes [0.03%]
Jesus Ayala-Sanmartin,Antonin Lamazière
Jesus Ayala-Sanmartin
The role of cholesterol in membrane lipid organization and ordering has been evidenced over the past twenty years. The participation of cholesterol precursors and other cholesterol derivatives in the modulation of cell membrane physicochemi...
Purification and structural characterization of the tularemia membrane protein virulence factors CapB and CapC [0.03%]
M Eranjalee Ranaweera,Rebecca J Jernigan,Krisha S Boradia et al.
M Eranjalee Ranaweera et al.
Francisella tularensis, the causative agent of tularemia, relies on the CapBCA membrane protein complex for intracellular survival and virulence, yet none of its components have been structurally characterized. Here, we report successful re...
Mechanical and energetic insights into pore formation in asymmetric lipid bilayers [0.03%]
不对称脂质双层孔形成的机械和能量见解
Zhaoyang Li,Wenjue Chu,Minmin Xue et al.
Zhaoyang Li et al.
Compositional asymmetry is a hallmark of biological membranes and plays a crucial role in pore formation. However, the molecular mechanism by which leaflet asymmetry influences pore formation remains unclear. Here, we employed molecular dyn...
Membrane interactions of designed cyclic RW peptides by solid-state NMR spectroscopy [0.03%]
固体核磁共振光谱法设计的环形RW肽膜相互作用研究
Kathakali De,Christopher Aisenbrey,Maria Hoernke et al.
Kathakali De et al.
Antimicrobial peptides (AMPs) are hoped to complement classical antibiotics in view of increasing microbial resistance. We investigate two members of a family of designed cyclic AMPs with different activity and selectivity. The cyclic hexap...
Léa Poskin,Lionel Porcar,Sylvain Prévost et al.
Léa Poskin et al.
Membrane proteins are essential for cellular communication and are frequently key targets for pharmaceutical intervention. However, their structural and dynamical characterization remains limited due to challenges associated with protein pr...
Molecular dynamic studies on the interaction of a TatA oligomer with Tat translocon substrates [0.03%]
TatA寡聚体与转录激活物-like效应因子AT家族效应蛋白动态相互作用研究
Vinh Tran,Terry M Bricker,Steven M Theg
Vinh Tran
The Tat translocon directly utilizes the Proton Motive Force to transport folded proteins from the n-side to the p-side of energized membranes. In most organisms the translocon consists of three subunits, TatA, TatB and TatC exhibiting a st...
Effects of N-glycosylation on the transport kinetics of organic anion transporting polypeptide (OATP) 1B1 [0.03%]
N-连接糖基化对有机阴离子转运多肽(OATP) 1B1运载动力学的影响
Manami Tanino,Kazunari Tsujii,Hiroki Kataoka et al.
Manami Tanino et al.
Organic anion transporting polypeptide (OATP) 1B1 is crucial for hepatic drug uptake. Three N-glycosylation sites, Asn134, Asn503, and Asn516, have been identified, and substituting the amino acid at these sites with glutamine reduces the e...
Mechanistic insights of arginine-based surfactant interaction with bacteria and mammalian model lipid membranes [0.03%]
基于精氨酸的表面活性剂与细菌和哺乳动物模型脂质膜相互作用的机制见解
Alejandro E Sabatie,Melisa Hermet,María Elisa Fait et al.
Alejandro E Sabatie et al.
Arginine-based surfactants exhibit antimicrobial activity attributed to their positive net charge and amphiphilic nature. These compounds typically disrupt cytoplasmic membranes, leading to cell leakage. We studied the mechanism of action o...
Nanodomain formation in lipid bilayers II: The influence of mixed-chain saturated lipids [0.03%]
混合链饱和脂质对双层脂质纳米域形成的影响II
Deeksha Mehta,Emily H Chaisson,Averi M Cooper et al.
Deeksha Mehta et al.
An important class of lipids found in biological membranes is composed of two structurally different hydrocarbon chains. Among these, low-melting lipids possessing both a saturated and unsaturated chain have been intensely studied because o...
Anke Mautner-Culetto,Marcel Huhn,Simon Schwarz et al.
Anke Mautner-Culetto et al.
The binding of local anesthetics (LAs) to cell membranes is required for LAs to reach the target ion channels, but lipid interactions may also play a role in a purely membrane-mediated mode of activity. Here, we used solid-state NMR and fur...