Longitudinal assessment activation of TGF-β1/pSmad2/3 signaling promotes hepatocyte reprogramming and fibrosis via Oct4, Sox9, and RunX2 in experimentally induced rats [0.03%]
Manisha Yadav,Shobhit Verma,Smriti Verma et al.
Manisha Yadav et al.
This study aimed to determine whether hepatocytes acquire stemness properties during their dedifferentiation toward myofibroblast-like phenotype and to evaluate the role of TGF-β1 signaling in mediating this process during liver fibrosis (...
18 kDa TSPO-mediated neurosteroidogenesis controls cholesterol homeostasis in tuning microglia response to inflammatory stimulus [0.03%]
Elisa Angeloni,Lorenzo Germelli,Laura Marchetti et al.
Elisa Angeloni et al.
In neurodegenerative diseases, microglia commonly accumulate toxic levels of cholesterol, compromising their ability to resolve the neuroinflammatory response. Here, we explored the role of neurosteroidogenesis, a complex cholesterol-metabo...
Etoposide suppresses skin cutaneous melanoma growth by inducing ferroptosis through p53-mediated transcriptional inhibition of TSP50 [0.03%]
Shuo Yang,Denghui Gao,Mingyue Li et al.
Shuo Yang et al.
Testis-specific protease 50 (TSP50), a tumor-associated antigen with minimal expression in normal tissues, emerges as a promising therapeutic target. In this study, we report its aberrant overexpression and proliferation-promoting role in s...
USP1 dependent stabilization of LTA4H drives hepatocellular carcinoma angiogenesis [0.03%]
USP1依赖的LTA4H稳定化驱动肝细胞癌血管生成
Banglong Xu,Yilin Wang,Zhaoyi Lin et al.
Banglong Xu et al.
Tumor angiogenesis is a major driver of hepatocellular carcinoma (HCC) progression, yet the tumor-intrinsic mechanisms that regulate endothelial activation remain incompletely understood. Here, we investigated the role of ubiquitin-specific...
Choline kinase beta promotes psoriasis pathogenesis by regulating sphingolipid metabolism and activating the PI3K/Akt/GSK3β signaling pathway [0.03%]
胆碱激酶β通过调节鞘脂代谢和激活PI3K/Akt/GSK3β信号通路促进银屑病的发病机制
Meijunzi Luo,Jie Gao,Maolin Jiang et al.
Meijunzi Luo et al.
Psoriasis is a chronic inflammatory skin disorder characterized by dysregulated lipid metabolism, yet the key molecular drivers remain unclear. This study aimed to identify and validate novel metabolic regulators in psoriasis. Using a multi...
Succinylation modification on NFS1 ameliorates the glucose starvation-induced ferroptosis through maintaining mitochondrial iron homeostasis in oral squamous cell carcinoma cells [0.03%]
NFS1蛋白琥珀酰化修饰通过维持铁死亡诱导的口腔鳞癌细胞线粒体铁稳态缓解葡萄糖饥饿诱导的铁死亡
Hang Ling,Limin Qing,Liang Zuo et al.
Hang Ling et al.
Background: NFS1 (cysteine desulfurase), an essential enzyme in iron-sulfur (FeS) cluster biogenesis, is a key regulator of ferroptosis. In oral squamous cell carcinoma (OSCC), NFS1 is up-regulated and undergoes enhanced ...
CLN5 disease-causing mutations impact lysosomal biology by affecting intracellular degradation and protein trafficking [0.03%]
CLN5疾病致病突变通过影响细胞内降解和蛋白质转运来干扰溶酶体生物学功能
William D Kim,Samer A Owiar,Cassandra H Pyne et al.
William D Kim et al.
Ceroid lipofuscinosis neuronal 5 (CLN5) disease is a subtype of neuronal ceroid lipofuscinosis (NCL, commonly known as Batten disease) that is caused by mutations in the CLN5 gene. While 70 distinct CLN5 disease-causing mutations have been ...
Shared pathogenic mechanisms between systemic lupus erythematosus and autoimmune hepatitis: A unified view of autoimmune convergence [0.03%]
系统性红斑狼疮和自身免疫性肝炎之间的共同发病机制：自身免疫汇聚的统一观点
Yechen Wu,Fengjiao Wang,Lanlan Xiao et al.
Yechen Wu et al.
Background: Systemic lupus erythematosus (SLE) and autoimmune hepatitis (AIH) are clinically distinct autoimmune disorders characterized by multisystem involvement and liver-restricted inflammation, respectively; neverthe...
Prophylactic systemic low-dose pirfenidone attenuates intrauterine adhesion by inhibiting the TGF-β1/Smad3 pathway [0.03%]
预防性系统低剂量吡非尼酮通过抑制TGF-β1/Smad3途径缓解宫腔粘连
Yuhang Zhang,Yuyin Liu,Xuewei Wu et al.
Yuhang Zhang et al.
Background: Intrauterine adhesion (IUA) is a severe fibrotic disorder lacking effective non-surgical treatments. This study explored pirfenidone (PFD), an antifibrotic drug approved for treating lung fibrosis, as a potent...
CD36 regulates metabolic reprogramming and early cluster formation of suspension cancer cells during metastatic progression [0.03%]
CD36通过调节转移进程中悬浮癌细胞代谢重组和早期聚集形成来促进癌症转移
Doru Kwon,Hyun Woo Park,Junjeong Choi
Doru Kwon
Introduction: Circulating tumor cell (CTC) clusters are potent mediators of metastasis, exhibiting dramatically enhanced survival and colonization potential compared to single CTCs. However, the molecular and metabolic pr...