An AAV-based bioluminescent reporter reveals dynamic YAP/TAZ-TEAD transcriptional activity during liver injury
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YAP/TAZ are central mechanosensitive regulators of liver injury, fibrosis, and regeneration; however, their dynamic activity in vivo remains challenging to monitor. Here, we establish an AAV8-delivered bioluminescent reporter system (rAAV-8 × GTIIC-Luc) that ... ...
