Stigmasterol alleviates central precocious puberty by targeting the IGF-1/PI3K/Akt/mTOR signaling pathway and modulating the Kisspeptin/GnRH axis [0.03%]
刺丝蛋白通过靶向IGF-1 / PI3K / Akt / mTOR信号通路和调节亲吻肽/GnRH轴来缓解中枢性早熟
Lin Dong,Yan Xing,Xiaoning Li et al.
Lin Dong et al.
Background: Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis, causing early sexual development and related health risks. Stigmasterol (ST), a natural phytostero...
Microbial influence on tryptophan metabolism in tumors:Mechanisms and potential clinical applications [0.03%]
肿瘤中微生物对色氨酸代谢的影响：机制及潜在临床应用
Rui Yang,Kaikai He,Yan Yang et al.
Rui Yang et al.
Tryptophan (Trp) metabolism represents a major biochemical interface between the gut microbiota, host immunity, and tumor biology. Trp is metabolized through three interconnected routes: the kynurenine (Kyn) pathway, mainly regulated by ind...
Characterization of responses to bleomycin-induced acute lung injury in female BALB/c mice [0.03%]
BALB/c雌鼠对博来霉素诱导的急性肺损伤的反应特征
Jaclynn A Meshanni,Rachel Sun,Sydni E Berkihiser et al.
Jaclynn A Meshanni et al.
Intratracheal bleomycin (ITB) administration in C57BL/6 J mice is an accepted model for the innate immune system in acute lung injury (ALI) with cell infiltration, alveolar wall thickening, loss of barrier function, and cell activation. We ...
Deciphering viral action on host genome structure: a computational physics perspective [0.03%]
从计算物理学角度解读病毒对宿主基因组结构的作用
Andrea Fontana,Andrea M Chiariello
Andrea Fontana
Recent experimental findings indicate that several viruses are able to substantially re-organize the host cell genome architecture. Since chromatin three-dimensional (3D) organization is tightly linked to vital cellular functions, investiga...
tRNA-derived fragment tRF-17-8SPOL52 induces resistance to bortezomib in multiple myeloma via autophagy activation [0.03%]
tRF-17-8SPOL52通过激活自噬作用诱导多发性骨髓瘤对硼替佐米的耐药性
Yunfeng Fu,Zhenrong Qiao,Yulian Xiao et al.
Yunfeng Fu et al.
Drug resistance limits the long-term survival of patients with multiple myeloma. The role of tRNA-derived fragments (tsRNAs) in bortezomib resistance in myeloma remains unknown. In this study, the most significantly upregulated tsRNA in rel...
Neuron-specific suppression of aberrantly active Toll-NFκB signalling mitigates pathogenic tau hyperphosphorylation via Gsk-3β in Drosophila [0.03%]
果蝇中神经元特异性抑制异常活化的Toll-NFκB信号可使病理性Tau过度磷酸化最小化（通过Gsk-3β）
Prerna Aggarwal,Surajit Sarkar
Prerna Aggarwal
Chronic brain ailments like Alzheimer's disease and Frontotemporal dementia, together referred to as tauopathies, are strongly influenced by neuroinflammation, an age-associated functional anomaly. Neuroinflammation arising from a dysfuncti...
NLRC3 suppresses hepatocarcinogenesis by disrupting the HSP90-mediated TRAF6/MYC signalling activation [0.03%]
NLRC3通过破坏HSP90介导的TRAF6/MYC信号激活来抑制肝细胞癌发生
Shishun Huang,Chen Zheng,Zheng Zhang et al.
Shishun Huang et al.
NLRC3 serves as a critical negative regulator of inflammatory signalling pathways and is implicated in the pathogenesis of multiple disorders, including inflammatory diseases and malignancies. However, the specific functions and underlying ...
NOX2-dependent macrophage-β-cell crosstalk exacerbate islet dysfunction in type 2 diabetes [0.03%]
NADPH氧化酶依赖的巨噬细胞-胰岛素细胞相互作用加重2型糖尿病中的胰岛功能障碍
Sihang Fang,Mingjun Jiang,Dizhi Liu et al.
Sihang Fang et al.
Lipotoxicity-induced β-cell failure in type 2 diabetes mellitus (T2DM) involves intrinsic damage and inflammatory crosstalk with islet macrophages, but the initiating signals remain undefined. We identify NOX2 as the hub linking metabolic ...
Hepatocyte OTUD1 deubiquitinates and activates ERK1/2 to promote acetaminophen-induced liver injury [0.03%]
肝细胞OTUD1通过去泛素化和活化ERK1 / 2促进乙酰氨基酚致肝损伤
Minxiu Wang,Yanni Zhao,Qianhui Zhang et al.
Minxiu Wang et al.
Acetaminophen (APAP)-induced liver injury is one of the most common causes of liver failure. However, the critical role of deubiquitinating enzymes (DUBs) in APAP-induced hepatotoxicity remains unknown. This study elucidated for the first t...
EGR2 promotes vascular smooth muscle cell differentiation and proliferation in outward remodeling during arteriovenous fistula maturation [0.03%]
EGR2促进动静脉瘘成熟期间外向重塑过程中血管平滑肌细胞的分化和增殖
Anni Song,Ruiwei Yan,Mingyu Huang et al.
Anni Song et al.
Arteriovenous fistula (AVF) maturation is characterized by outward remodeling presented mainly as wall thickening and lumen enlargement, probably mediated by increased differentiated vascular smooth muscle cells (VSMCs) and extracellular ma...