Targeting 15-PGDH/15-oxoETE to mitigate inflammation and senescence in asthma [0.03%]
靶向15-PGDH / 15-氧代ETE以缓解哮喘中的炎症和衰老
Hongxia Bao,Jihong Ren,Kexin Zhao et al.
Hongxia Bao et al.
Asthma is a chronic airway disease characterized by airway inflammation and remodeling. While 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and its metabolic product 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-oxoETE), are known to par...
Orosomucoid 2 as an immunometabolic regulator in cardiometabolic disease: Molecular mechanisms and translational potential [0.03%]
载脂蛋白急性期反应蛋白或SOMN在心血管代偿反应中的免疫代谢调节作用：分子机制与转化潜力
Xia Sun,Wen Shen,Xiang Tang et al.
Xia Sun et al.
Cardiometabolic diseases are driven by persistent crosstalk between metabolic dysfunction and chronic low-grade inflammation. Orosomucoid 2 (ORM2), a highly glycosylated acute-phase protein of the α1-acid glycoprotein family, has conventio...
In vivo dysregulation of insulin and glucagon secretion: Disturbed mitochonderial VDAC1 expression and localization in pancreatic β-cells convey global insulin secretory defects in diabetic GK rat [0.03%]
体内胰岛素和胰高血糖素分泌失调：胰腺β细胞线粒体VDAC1表达及定位紊乱导致GK糖尿病大鼠整体胰岛素分泌缺陷
Albert Salehi,Israa Muhammed Al-Amily,Fariborz Parandeh et al.
Albert Salehi et al.
The mildly diabetic Goto-Kakizaki (GK) rat is widely used to study type 2 diabetes (T2D), yet the mechanisms underlying defective insulin secretion in this model remain incompletely understood. We therefore investigated the effects of multi...
B3GNT2 promotes gastric cancer metastasis by facilitating membrane trafficking of RYK via N-glycosylation [0.03%]
B3GNT2通过促进RYK的N-糖基化介导的膜转运来促进胃癌转移
Yongan Fu,Yangqiang Wang,Zongda Cai et al.
Yongan Fu et al.
Background: Gastric cancer (GC) is characterized by a high metastatic propensity, which constitutes the primary cause of poor patient prognosis. Receptor-like tyrosine kinase (RYK) is associated with GC metastasis, but it...
An AAV-based bioluminescent reporter reveals dynamic YAP/TAZ-TEAD transcriptional activity during liver injury [0.03%]
基于AAV的生物发光报告系统揭示在肝损伤过程中YAP/TAZ转录活性的动力学变化
Jianyu Ye,Chen Luo,Zhongning Yang et al.
Jianyu Ye et al.
YAP/TAZ are central mechanosensitive regulators of liver injury, fibrosis, and regeneration; however, their dynamic activity in vivo remains challenging to monitor. Here, we establish an AAV8-delivered bioluminescent reporter system (rAAV-8...
Small-molecule LIFR inhibitors attenuate renal tubulointerstitial fibrosis [0.03%]
小分子LIFR抑制剂可减轻肾小管间质纤维化
Jia Xin Zhou,Tan Tan Long,Yiqiao Liu et al.
Jia Xin Zhou et al.
Renal tubulointerstitial fibrosis (TIF), the final common pathway of chronic kidney disease (CKD), is driven by pathological crosstalk between fibroblasts and tubular epithelial cells (TECs). Leukemia inhibitory factor (LIF) contributes to ...
Tingyi Sun,Shilong Hu,Tianyi Xu et al.
Tingyi Sun et al.
Oxidative stress is a pivotal initiator of organismal aging. Targeted antioxidant interventions can effectively slow this process; however, the optimal timing for these interventions remains controversial. In this study, we observed that wi...
DNA methylation-mediated downregulation of MEIS2 correlates with tumor development and progression in gastric cancer [0.03%]
胃癌中MEIS2甲基化抑制与肿瘤发生及进展有关
Yangyu Zhang,YanHua Wu,Donghui Cao et al.
Yangyu Zhang et al.
Background: Gastric cancer (GC) is a molecularly heterogeneous disease with poor prognosis. DNA methylation plays a critical role in its pathogenesis, and Homeobox genes are known to be frequently dysregulated through epi...
A proliferation-inducing ligand enhances the anti-tumor effect of BCMA CAR T-cell through inhibition of soluble BCMA [0.03%]
增殖诱导配体通过抑制可溶性BCMA增强BCMA CAR-T细胞的抗肿瘤效果
Huanhuan She,Jiahan Lin,Dian Zhou et al.
Huanhuan She et al.
A proliferation-inducing ligand (APRIL), a ligand of B-cell maturation antigen (BCMA), might have an impact on the efficacy of BCMA CAR T-cell in multiple myeloma. Here, we found plasma concentrations of APRIL increased (> 1 nM) during the ...
Emerging roles of SIRT7 in metabolic homeostasis and related disorders [0.03%]
SIRT7在代谢稳态及相关的紊乱中的作用机制研究
Siqi Yu,Lawan Rabiu,Wei-Guo Zhu et al.
Siqi Yu et al.
Metabolic diseases, including type 2 diabetes mellitus, obesity, and metabolic dysfunction-associated steatotic liver disease, are major global health challenges, sharing features such as disrupted glucose-lipid homeostasis, mitochondrial d...