Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy [0.03%]
维庭素靶向USP49-GRPR去泛素化轴在髓样甲状腺癌治疗中的作用
Qing Xia,Shuai Dong,Wenjun Xu et al.
Qing Xia et al.
Medullary thyroid carcinoma (MTC) is a rare, aggressive neuroendocrine malignancy with limited therapeutic options, often exhibiting resistance to targeted therapies. This study demonstrates that the natural flavonoid vitexin suppresses MTC...
H3K9 lactylation drives FTO-mediated NRF2 suppression to exacerbate bladder epithelial ferroptosis and inflammation in diabetic bladder dysfunction [0.03%]
糖尿病性膀胱功能障碍中H3K9乳酰化驱动FTO介导的NRF2抑制加重膀胱上皮细胞铁死亡和炎症
Zongyao Fan,Bin Ni,Zheng Duan et al.
Zongyao Fan et al.
Diabetic bladder dysfunction (DBD), a prevalent yet underexplored complication of diabetes, manifests as debilitating lower urinary tract symptoms (LUTS), such as urinary frequency, urgency, incontinence, and voiding difficulties, significa...
Prolyl-hydroxylase domain inhibition enhances collagen levels in oral mucosa-derived fibroblasts [0.03%]
脯氨酰羟化酶城域抑制增强口腔粘膜成纤维细胞中胶原蛋白水平
Sivan Najar,Itay Kilimink,Bar Shahar et al.
Sivan Najar et al.
Fibroblast cells are a primary source of collagen, playing a vital role in maintaining the structural integrity of the oral mucosa. Given that hypoxia upregulates collagen levels in oral mucosa-derived fibroblasts (OMDFs), this study aims t...
Calpain activation disrupts ER-Phagy and leads to mitochondrial damage in hearts treated with isoproterenol [0.03%]
钙蛋白激活破坏内质网自噬并导致异丙肾上腺素治疗的心脏线粒体损伤
Qun Chen,Ling Li,Jeremy Thompson et al.
Qun Chen et al.
The endoplasmic reticulum (ER) is a dynamic organelle whose homeostasis is maintained by ER-phagy (ERPG). Under conditions of ER stress, calcium-dependent cysteine proteases-specifically calpain 1 and calpain 2 (CPN1/2)-are activated and co...
Vimentin-targeting adaptogen withaferin A: Potential to selectively suppress cervical cancer - Single-cell microspectroscopic and molecular analysis [0.03%]
targeting宫颈癌的单细胞微光谱及分子分析
Ewa Pięta,Agnieszka Panek,Monika Szczepanek-Dulska et al.
Ewa Pięta et al.
This study investigates the preferential anticancer effects of withaferin A, an adaptogenic compound, on primary and metastatic cervical cancer cells (C-33 A and CaSki, respectively) and non-cancerous skin fibroblast cells (Detroit-551). Em...
Swimming exercise attenuates diabetic myopathy and is associated with histological and mitochondrial changes in pregnant rats (Rattus norvegicus) [0.03%]
游泳运动可缓解妊娠大鼠糖尿病肌肉病并与其组织学及线粒体变化相关
Bruna Bologna Catinelli,Angélica Mércia Pascon Barbosa,Aline Medolago Carr et al.
Bruna Bologna Catinelli et al.
Aim: Diabetic-induced myopathy (DiM) is reversed by swimming exercise (SE) in diabetic pregnant rats. This study aims to characterise the role of muscle stem cells (MuSCs), mitochondrial adaptations, and inflammation in t...
Astragalus polysaccharide hinders cervical cancer immune escape by targeting NR3C2 and activating SLC40A1 [0.03%]
黄芪多糖通过靶向NR3C2并激活SLC40A1抑制宫颈癌免疫逃逸
Wenzhi Liu,Lu Zhang,Yixin Wang et al.
Wenzhi Liu et al.
Astragalus polysaccharides (APS) show promising effects in preventing tumor progression and immune escape. This study investigated the mechanism of APS in immune escape in cervical cancer (CC). The effects of different APS concentrations on...
NR5A2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting MMP25 transcription [0.03%]
NR5A2通过靶向MMP25转录促进肾纤维化中上皮间质转化
Xiao Wang,Yinong Chang,Yong Qian et al.
Xiao Wang et al.
Renal fibrosis is a hallmark of chronic kidney disease (CKD), with epithelial-mesenchymal transition (EMT) recognized as a key contributing process. Here, we identify nuclear receptor NR5A2 as an important regulator that promotes EMT in ren...
USP38 deficiency mitigates arrhythmogenic remodeling in obese mice by inhibiting TLR4/CaMKII signaling [0.03%]
USP38通过抑制TLR4/CaMKII信号通路缓解肥胖小鼠心律失常重塑
Tao Chen,Hongjie Yang,Yang Gong et al.
Tao Chen et al.
Obesity-associated metabolic disturbances and cardiac remodeling significantly contribute to ventricular arrhythmias (VAs), a leading cause of sudden cardiac death. Although our previous studies have implicated the deubiquitinase USP38 in c...
Urolithin A protects against calcium oxalate-induced crystal formation and kidney injury by regulating PCK1 to restore mitophagy function in kidney stone disease [0.03%]
花青素A通过调节PCK1恢复肾结石疾病中自噬功能以保护机体免受草酸钙诱导的晶体形成和肾脏损伤的作用
Xiaoyi Sun,Chunlin Gao,Pei Zhang et al.
Xiaoyi Sun et al.
Kidney stone disease (KSD) is one of the most common urological disorders, and oxalate-induced tubular epithelial cell injury plays a crucial role in stone-related renal damage. However, the mechanisms linking oxalate exposure to mitochondr...