GRIMM-II: A two-stage real-time algorithm for nine-locus HLA imputation and matching with up to three mismatches [0.03%]
改进版的GRIMM算法：一个能够实现HLA九位基因座不完全匹配供者的实时搜索算法
Ofek Kirshenboim,Amit Kabya,Regev Yehezkel-Imra et al.
Ofek Kirshenboim et al.
Background: The success of hematopoietic stem cell transplantation (HSCT) depends critically on human leukocyte antigen (HLA) matching between donor and recipient. While traditional matching focuses on five classical HLA ...
"THE SAB GAP": incomplete HLA allele representation in Single Antigen Bead assays and its implications for surrogate epitope-level representation in an Indian transplant cohort [0.03%]
“SAB间隙”：单抗原珠试验中不完整的HLA等位基因表达及其在一个印度移植队列中的替代表位水平表达的含义
Mohit Chowdhry,Ayushi Yadav,Jayagowri Karthikeyan
Mohit Chowdhry
Background: Single Antigen Bead (SAB) assays are widely used for anti-HLA antibodies detection and virtual crossmatch. Their interpretation assumes that omission of specific HLA alleles can be adequately compensated throu...
Serum sPD-1 and sTIM-3 as T-cell exhaustion biomarkers in systemic lupus erythematosus: the IL-6-associated exhaustion axis and the SLE Immune Exhaustion Index [0.03%]
系统性红斑狼疮中血清sPD-1和sTIM-3作为T细胞耗竭生物标志物：与IL-6相关的耗竭轴及SLE免疫耗竭指数
Abdullah Salim Al-Karawi,Ali Saad Al-Budairi
Abdullah Salim Al-Karawi
Background: T-cell exhaustion marked by soluble PD-1 (sPD-1) and soluble TIM-3 (sTIM-3) has been implicated in systemic lupus erythematosus (SLE), yet the cytokine mechanisms driving checkpoint-receptor upregulation, the ...
Immunogenetic diversity of two South Asian cohorts, from Pakistan and India [0.03%]
来自巴基斯坦和印度两个南亚队列的免疫遗传多样性
Katherine M Kichula,Neus Font-Porterias,Nicholas R Pollock et al.
Katherine M Kichula et al.
Having critical roles in immune defense and reproduction, killer cell immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) class I ligands are encoded by the most polymorphic regions in the human genome. South Asia co...
Integrating immunogenetic stratification and follicular immune dynamics: an evolving framework for CAR-Treg therapy in antibody-mediated rejection [0.03%]
免疫遗传分层与滤泡免疫动力学的整合：抗体介导排斥反应中CAR-Treg治疗的新兴框架
Nurten Sayin Ekinci,Habibe Sema Arslan Unal
Nurten Sayin Ekinci
One of the leading causes of long-term graft loss following kidney transplantation is antibody-mediated rejection (AMR). In this process, donor-specific antibodies (DSAs), arising either from pre-transplant sensitization or developing de no...
IL10 promoter variants in neurocysticercosis: family-based susceptibility and exploratory genotype-phenotype analyses in Mexican case-parent trios [0.03%]
墨西哥病例父母三联体在神经囊尾蚴病中的易感性及其探索性的基因型表型分析：由IL10启动子变异引起
M Villegas,A Fleury,C Alaez et al.
M Villegas et al.
Given the central role of neuroinflammation in neurocysticercosis (NCC), IL10 promoter variation may influence susceptibility and disease expression. We analyzed rs1800896 (-1082 A > G), rs1800871 (-819C > T), and rs1800872 (-592C > A), tog...
Investigation of ACE gene polymorphism and serum ACE activity in relation to alopecia areata among Iraqi patients [0.03%]
伊拉克脱发患者的ACE基因多态性和血清ACE活性的相关研究
Dalya Jamal Dhahir,Mohammed A Mohammed,Mohammad M F Al-Halbosiy
Dalya Jamal Dhahir
Background: Alopecia areata (AA) is a multifactorial disorder with immune dysregulation and genetic susceptibility, affecting 0.5-2% globally. Objective: ...
Establishing "Glycoantigens" as a cross-field concept in Glycobiology, transfusion, transplant, and immunology [0.03%]
在糖生物学、输血、移植和免疫学中建立“糖抗原”作为跨领域概念
William J Lane
William J Lane
Cell-surface glycans (carbohydrate structures) serve as critical antigens in transfusion and transplantation, yet their study remains fragmented across disciplines. The ABO blood group system, the most clinically tested glycan compatibility...
Association between subclinical atherosclerosis and NLRP3 rs10157379 and rs10754558 genetic variants, inflammatory, and metabolic biomarkers in HIV-1 infection [0.03%]
HIV-1感染中亚临床动脉粥样硬化与NLRP3基因多态性、炎症及代谢标志物的关系
Philipe Quagliato Bellinati,Marcell Alysson Batisti Lozovoy,Tainah Mendes Ahrens et al.
Philipe Quagliato Bellinati et al.
The NLRP3 inflammasome, along with inflammatory and metabolic biomarkers, has been implicated in atherosclerosis. This study aimed to investigate the association between subclinical atherosclerosis and NLRP3 rs10157379 T > C and rs10754558 ...
Blocking the aryl hydrocarbon receptor (AhR) protects CD4+ T cells from Th17/Treg differentiation imbalance through SENP1-mediated deSUMOylation [0.03%]
通过SENP1介导的脱SUMO化保护CD4+T细胞免于Th17/Treg分化失衡及aryl hydrocarbon受体(AhR)阻滞的作用
Jiao Ge,Yan Liu
Jiao Ge
Background: Immune thrombocytopenic purpura (ITP) is the most common autoimmune bleeding disorder in children and poses a serious threat to pediatric health and survival. An imbalance in Th17 and Treg cell differentiation...