Long-term safety and efficacy of deoxycytidine/deoxythymidine in treatment of POLG-related disorders [0.03%]
脱氧胞苷/脱氧胸苷治疗POLG相关障碍的长期安全性和有效性研究
Anthony C T Cheung,Saoussen Berrahmoune,Christelle Dassi et al.
Anthony C T Cheung et al.
We evaluated the safety and efficacy of enteral deoxycytidine/deoxythymidine combination therapy in treatment of POLG-related disorders, genetic mitochondrial diseases characterized by progressive neurological degeneration. A single-centre ...
Opportunities for the future of transcranial magnetic stimulation and epilepsy [0.03%]
经颅磁刺激和癫痫的未来展望
Brian N Lundstrom,Alexander Rotenberg
Brian N Lundstrom
Drug-resistant epilepsy has traditionally been managed with medications or surgery aimed at removing or destroying epileptogenic tissue. In contrast, electrical brain stimulation seeks to alter dysfunctional neural circuits without tissue d...
Myelin debris uptake by macrophages and microglia: Resolution of foam cells with a series of novel cyclodextrins [0.03%]
新型环糊精系列化合物促进髓鞘泡沫细胞化解清除的作用研究
Emily C Wuerch,Charbel S Baaklini,Ping Zhang et al.
Emily C Wuerch et al.
Foamy, lipid-laden macrophages are found in multiple sclerosis (MS) lesions, resulting from excessive phagocytosis of myelin debris following demyelination. These lipid-laden macrophages exhibit an inflammatory phenotype, inhibit remyelinat...
Converging on control: Rethinking treatment-resistant depression through network neuroscience [0.03%]
控制的汇聚：通过网络神经科学重新思考治疗抵抗性抑郁
Yoshihiro Noda
Yoshihiro Noda
Short-term effects of ocrelizumab on cortical pathology in patients with multiple sclerosis [0.03%]
奥马珠单抗对多发性硬化患者皮质病理改变的短期影响
N Cavalli,G Boffa,E Cipriano et al.
N Cavalli et al.
Cortical lesions (CLs) are a common finding in multiple sclerosis (MS) but data regarding the impact of treatment on their evolution are lacking. This study evaluates CLs status and new CLs accrual over two-year follow-up in a cohort of pat...
The effectiveness of transcranial photobiomodulation therapy (tPBM) and transauricular vagus nerve stimulation (taVNS) on reducing alcohol craving [0.03%]
经颅光生物调节疗法(tPBM)和经耳迷走神经刺激(taVNS)减轻饮酒渴求的效果
Manjae Kwon,Minkyung Park,Minjae Kim et al.
Manjae Kwon et al.
Alcohol craving plays a central role in sustaining alcohol use and contributing to relapse. Noninvasive neuromodulation techniques such as transcranial photobiomodulation (tPBM) and transauricular vagus nerve stimulation (taVNS) may target ...
Shiva Nematgorgani,Jane M Brandon,Gregory Dussor
Shiva Nematgorgani
Migraine is a complex neurologic disorder with a significant global burden. Mast cells, a type of immune cell residing in the meninges and in close contact with dural afferent neurons, have been proposed to play an important role in the pat...
The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein [0.03%]
PDE5抑制剂戊扎菲林通过淀粉样蛋白-β和细胞朊病毒蛋白增强谷氨酸能传递
Md Abdullah A Kafi,Mario Passalacqua,Viviana Villa et al.
Md Abdullah A Kafi et al.
Memory and synaptic plasticity are regulated by cyclic guanosine monophosphate (cGMP) signaling. Phosphodiesterase 5 (PDE5) inhibitors, such as vardenafil (VDF), elevate intracellular cGMP levels and represent potential therapeutics for cog...
Prolonged venous transit on perfusion imaging predicts discharge Cog-4 scores in anterior-circulation large-vessel occlusion stroke [0.03%]
灌注成像上的静脉淤滞可预测前循环大血管闭塞卒中出院时的认知功能-Cog-4评分
Hamza Adel Salim,Andrew Cho,Derek Tsang et al.
Hamza Adel Salim et al.
Post-stroke cognitive impairment is common after acute ischemic stroke, yet early cognitive deficits are often underrecognized in routine care. Prolonged venous transit (PVT) on perfusion imaging reflects impaired venous drainage and has be...
Cognitive and structural brain changes in ofatumumab-treated multiple sclerosis: A longitudinal study [0.03%]
奥法木单抗治疗多发性硬化症的认知和结构脑变化的纵向研究
Aurora Zanghì,Paola Sofia Di Filippo,Carlo Robusto et al.
Aurora Zanghì et al.
Anti-CD20 therapies control inflammatory activity in multiple sclerosis (MS), but their effects on neurodegeneration and cognition in real-world settings remain uncertain. We conducted a longitudinal observational study of relapsing MS (RMS...