Activation of GABA transmission by clonazepam reverses the autistic-like phenotypes of the Cav3.2 knockout mice [0.03%]
氯氮卓激活GABAA能传递可逆转CACNA1I基因敲除小鼠自闭症样表型
Shao-Feng Liang,Yang Ming,Hsien-Ting Huang et al.
Shao-Feng Liang et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication deficits, accompanied by restricted and repetitive behaviors. ASD is a lifelong condition that causes a heavy medical and societal bur...
Intrathecal STAT3 inhibitor Bt354 ameliorates chronic constriction injury-induced nociceptive sensitization by modulating neuroinflammation [0.03%]
STAT3抑制剂Bt354脊髓给药通过调节神经炎症缓解慢性约束损伤诱导的痛觉过敏反应
Hao-Jung Cheng,Nan-Fu Chen,Yueh-Chiao Tang et al.
Hao-Jung Cheng et al.
Neuropathic pain poses a significant societal and clinical burden and is closely linked to neuroinflammation of the central nervous system. Signal transducer and activator of transcription 3 (STAT3) is a key regulator of inflammatory proces...
Prevalence of hypogammaglobulinemia after non-anti-CD20 therapies and impact of switching to rituximab/ocrelizumab in multiple sclerosis [0.03%]
非抗CD20疗法后的低丙球蛋白血症的发病情况及其转换为利妥昔单抗/奥瑞珠单抗对患者的影响（多发性硬化）
Marine Perriguey,Camille Rigollet,Sean A Freeman et al.
Marine Perriguey et al.
Some people with multiple sclerosis (PwMS) exhibit reduced serum immunoglobulin (Ig) levels, potentially due to disease-modifying therapies (DMTs), which raises concerns about initiating anti-CD20 therapies. We assessed the frequency of hyp...
Whole transcriptome analysis of peripheral blood mononuclear cells from de novo and drug-naive Parkinson's disease patients [0.03%]
特发性帕金森病和药物未治疗PD患者的外周血单个核细胞的全转录组分析
Francisco Navarrete,Marina Guillot-Fernández,Lorena Martínez-Hostyn et al.
Francisco Navarrete et al.
Blood-based biomarkers represent a highly convenient and minimally invasive method to improve the diagnosis of Parkinson's disease (PD), particularly at early stages. In this study, we present a comprehensive analysis of transcriptional cha...
Neuroprosthetic closed-loop strategy for sustained blood pressure reduction via simultaneous stimulation and recording from the spinal cord [0.03%]
通过脊髓的同步刺激和记录实现神经假体闭环策略以持续降低血压
Mingeun Cho,Minhye Choo,Matthew Koh et al.
Mingeun Cho et al.
Sympathetic hyperactivity is a common feature observed in both primary and secondary hypertension, and neuromodulation-based therapies targeting this overactivity are under active investigation. The intermediolateral nucleus (IML) in the sp...
Beyond the synapse: Bassoon mutations drive epilepsy through Astrocyte-Neuron crosstalk [0.03%]
突触之外：Pallidol神经元-胶质通讯诱发小鼠的遗传性癫痫发作
Xindi Li,Ronald P Hart,Zhiping P Pang
Xindi Li
Inhibition of microglial glutaminase alleviates chronic stress-induced neurobehavioral and cognitive deficits [0.03%]
微胶质细胞谷氨酰胺酶抑制缓解慢性压力引起的神经行为和认知缺损
Meixiang Huang,Yannan Li,Ajit G Thomas et al.
Meixiang Huang et al.
Major depressive disorder (MDD) is a prevalent and debilitating psychiatric condition with significant societal and economic impacts. Many patients are resistant to current antidepressant therapies, underscoring the need for novel treatment...
Metabolomics and lipidomics study on serum metabolite signatures in Alzheimer's disease and mild cognitive impairment [0.03%]
基于血清代谢标志物的阿尔茨海默病及轻度认知障碍的代谢组学和脂质组学研究
Yingren Mai,Fengjie Huang,Hongyan Mi et al.
Yingren Mai et al.
Alzheimer's disease (AD) and mild cognitive impairment (MCI) are major causes of dementia in the elderly, with metabolic alterations not fully understood. In this study, we quantitatively profiled serum metabolites of participants in 2 inde...
LINE-1 hypomethylation in cell-free DNA of high-grade glioma patients correlates with tissue levels and is associated with reduced DNMT1 and H4K20me3 expression [0.03%]
高_grade_胶质瘤患者细胞_free_DNA中LINE-1低甲基化与组织水平相关，并且DNMT1和H4K20me3表达降低有关
Angeliki-Ioanna Giannopoulou,Panagiotis Skouras,Panagiotis Sarantis et al.
Angeliki-Ioanna Giannopoulou et al.
Gliomas exhibit diverse genetic, molecular, and histological profiles with limited liquid biopsy biomarkers. Loss of Long Interspersed Nuclear Element-1 (LINE-1) methylation confers to genomic instability and tumorigenesis, primarily mediat...
Synergistic mitochondrial impairment by endogenously elevated cyanide and hydrogen sulfide in Down syndrome; commentary on: Cyanide overproduction impairs cellular bioenergetics in Down syndrome [0.03%]
下综合征中氰化物和氢硫化物的内源性升高导致的协同性线粒体功能障碍；对“下综合征中的过量氰化物生成会损害细胞生物能量”的评论
Andrew A Pieper,Bindu D Paul
Andrew A Pieper