The PDE5 inhibitor vardenafil enhances glutamatergic transmission through amyloid-beta and cellular prion protein
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Memory and synaptic plasticity are regulated by cyclic guanosine monophosphate (cGMP) signaling. Phosphodiesterase 5 (PDE5) inhibitors, such as vardenafil (VDF), elevate intracellular cGMP levels and represent potential therapeutics for cognitive disorders, in... ...
