Ellen J Bubrick,Lillian H Stapelfeld,Parker Kotlarz et al.
Ellen J Bubrick et al.
NAcLat-DBS reduces GABAB expression of dopamine neurons to correct depressive symptoms in CMS mice [0.03%]
NAcLat-DBS通过降低多巴胺神经元GABAB表达来纠正慢性束缚应激小鼠的抑郁样症状
Jia-Ni Jing,Chao Yuan,Xia Li et al.
Jia-Ni Jing et al.
Hypodopaminergic activity within the mesolimbic circuitry is recognized as a typical characteristic in severe and refractory depression. Deep brain stimulation (DBS) of the nucleus accumbens (NAc) has shown therapeutic potential for treatme...
Wild-type C9orf72 drives proteasomal dysfunction and mutant aggregates via a Stat1-Isg15 axis in Huntington's disease [0.03%]
野生型C9orf72通过Stat1-Isg15轴驱动亨廷顿舞蹈病中的蛋白酶体功能障碍和突变聚集体形成
Siew Chin Chan,Chih-Wei Tung,Chih-Yi Chang et al.
Siew Chin Chan et al.
Mutant C9orf72 has been extensively studied as a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, and is also known to generate Huntington's disease (HD)-like phenocopies. However, despite this strong diseas...
Natalia Claire Mendonca,Longsha Liu,Kok-Siong Chen et al.
Natalia Claire Mendonca et al.
The profound challenge in treating glioblastoma (GBM) stems from a confluence of obstacles. The formidable blood-brain barrier (BBB) limits drug access, while the tumor's inherent inter- and intra-tumoral heterogeneity, profound immunosuppr...
NTI164, a novel medicinal cannabis extract, improves core symptoms of autism spectrum disorder: Results from a double-blind, randomised, controlled trial (The Harmony study) [0.03%]
新型医用大麻提取物NTI164可改善自闭症核心症状：一项双盲随机对照试验（和谐研究）的结果
Brooke A Keating,Yelda Ogru,Esra Isikgel et al.
Brooke A Keating et al.
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder, characterised by difficulties with communication, social interaction, repetitive behaviours, restricted interests, and varying levels of intellectual disability....
Intrabody B1 targeting TDP-43 modulates neuroinflammatory and metabolic pathways in a preclinical ALS model [0.03%]
靶向TDP-43的细胞内抗体B1可调节神经炎症和代谢通路以治疗渐冻症小鼠模型
Y Al Ojaimi,A Dupuis,M Palla et al.
Y Al Ojaimi et al.
TDP-43 pathology is a hallmark of Amyotrophic Lateral Sclerosis (ALS), yet no therapeutic strategy effectively targets its upstream molecular consequences. Here, we investigated whether the anti-TDP-43 intrabody scFv B1 modulates neuroinfla...
Rhiannon L Cowan,Edward M Merricks,Tyler S Davis et al.
Rhiannon L Cowan et al.
Invasive neurostimulation has been used in humans to treat and diagnose epilepsy for decades. Despite such ubiquitous probing and recording from the human brain, the efficacy of surgical outcomes has remained stable. One potential reason fo...
Transcranial alternating current stimulation as treatment for delirium: A multicenter randomized double-blind sham-controlled pilot study on safety and feasibility [0.03%]
经颅交流电刺激治疗谵妄：一项多中心随机双盲假刺激对照试点研究的安全性和可行性研究
Julia van der A,D Yorben Lodema,Edwin van Dellen et al.
Julia van der A et al.
Delirium is an acute neuropsychiatric syndrome with currently no effective treatment. The acute encephalopathy underlying delirium is characterized by diffuse oscillatory slowing on electroencephalography (EEG). Based on its capacity to mod...
A bitter melon natural compound ameliorates the myotonic dystrophy type 1 skeletal muscle phenotype in a sex-specific manner [0.03%]
苦瓜中的天然化合物以性别特异性方式改善I型肌强直性营养不良的骨骼肌表型
Shatha A Atieh,Chimène Fahmi,Jia Liu et al.
Shatha A Atieh et al.
Myotonic Dystrophy Type 1 (DM1) is a multisystemic neuromuscular disease characterized by severe skeletal muscle dysfunction. The etiology of DM1 is primarily driven by RNA toxicity resulting from a gain-of-function mutation in DMPK mRNAs. ...
Exosome-mediated delivery of 3-n-butylphthalide rescues microglial energy crisis and ameliorates neuroinflammation in ischemic stroke [0.03%]
外泌体介导的丁苯酞递送可缓解缺血性卒中后的少突胶质细胞线粒体能量危机及神经炎症
Bangyue Wang,Muchen Xi,Keyi Lin et al.
Bangyue Wang et al.
Stroke remains the second leading cause of death and the primary cause of long-term disability worldwide, with ischemic stroke accounting for the majority of cases. Ischemia triggers robust microglial activation, yet the precise regulatory ...