Sara Daniella Kevelson,Rana Elmaghraby,Fenil Patel et al.
Sara Daniella Kevelson et al.
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with limited treatment options that address its full complexity. This review critically evaluates novel therapeutics across five key domains: behavioral and psyc...
Down-regulation of lipocalin-2 alleviates depressive-like behaviors in mice through modulation of microglial activation [0.03%]
下调脂联素-2通过调节小胶质细胞活化缓解小鼠类似抑郁的行为
Xiaoyu Yu,Shulei Gao,Yunguang Chen et al.
Xiaoyu Yu et al.
Although the pathophysiological underpinnings of major depressive disorder (MDD) are increasingly recognized to involve microglia-mediated neuroinflammation, the underlying molecular processes are still not fully understood. To identify key...
Silmitasertib, an FDA-designated orphan CK2 inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse model [0.03%]
一种FDA认定的针对亨廷顿小鼠模型孤儿CK2抑制剂Silmitasertib的罕见病药物，可改善神经病理学和运动功能障碍
Ross J Pelzel,Miaya Herbst,Nicholas B Rozema et al.
Ross J Pelzel et al.
Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease that manifests with progressive motor, cognitive, and psychological impairments. HD is caused by a CAG (glutamine) repeat expansion in the huntingtin (H...
Mapping the genetic landscape of suicide risk: Insights from genomic SEM [0.03%]
自杀风险的遗传图谱：来自基因组SEM的见解
Kaifang Yao,Chuanjun Zhuo,Ximing Chen et al.
Kaifang Yao et al.
The genetic basis of traits associated with suicide risk remains poorly understood. We applied genomic structural equation modeling and integrated multiple post-genome-wide association study (GWAS) analysis strategies to identify potential ...
Intravenous miR-30c therapy confers dual neurovascular protection and improves long-term recovery after ischemic stroke [0.03%]
静脉注射miR-30c疗法在缺血性脑卒中后具有双重神经血管保护作用并改善长期预后
Rong Jin,Manish Shukla,Wei Zhong et al.
Rong Jin et al.
Ischemia-reperfusion (I/R) injury is a major barrier to effective reperfusion therapy in acute ischemic stroke. Secondary microvascular thrombosis and neuronal endoplasmic reticulum (ER) stress are major contributors to poor outcomes, yet t...
Plasma levels of thrombin-cleaved osteopontin as a surrogate biomarker of subsequent chronic shunt-dependent hydrocephalus development following aneurysmal subarachnoid hemorrhage [0.03%]
动脉瘤性蛛网膜下腔出血后纤维蛋白酶切割骨桥素作为随后慢性脑室-腹膜分流依赖性脑积水发生的替代生物标志物的血浆水平
Kazuaki Aoki,Fumihiro Kawakita,Koichi Hakozaki et al.
Kazuaki Aoki et al.
Chronic shunt-dependent hydrocephalus (SDHC) is a major contributor to poor outcome after aneurysmal subarachnoid hemorrhage (aSAH), reportedly with arachnoid fibrosis implicated in its pathophysiology. In the pathogenesis of fibrosis, N-te...
Advances in neuropsychiatry: From objective diagnostics to mechanism-based therapeutics [0.03%]
神经精神病学进展：从客观诊断到基于作用机制的治疗
Andrew A Pieper,Francis S Lee
Andrew A Pieper
Blood-brain barrier penetration determines link between beta blockers and reduced mortality in patients with sepsis-associated encephalopathy: A multicenter cohort study and an effect heterogeneity tool [0.03%]
β阻滞剂降低脓毒症相关性脑病患者死亡率与通过血脑屏障有关：一项多中心队列研究和一种效应异质性工具分析
Kai Wang,Mengshi Xia,Yuxiang Long et al.
Kai Wang et al.
Clinical evidence for beta (β) blockers in sepsis-associated encephalopathy (SAE) is limited, and the influence of blood-brain barrier penetration (BBBp) on their neuroprotective efficacy remains unclear. We analyzed 17,446 SAE patients fr...
Network-based prediction and real-world patient data observation identify doxycycline as a repurposable drug in Alzheimer's disease [0.03%]
基于网络的预测和真实世界患者数据观察识别多西环素作为阿尔茨海默病的再定位药物
Marina Bykova,Ehud Karavani,Michael Danziger et al.
Marina Bykova et al.
Alzheimer's disease (AD), a leading global cause of dementia, disability, and mortality, represents a critical unmet need for effective therapeutic interventions. Drug repurposing offers an expedited pathway to address this challenge compar...
KITENIN-CCL20 axis is a potential therapeutic target for modulating immunosuppressive tumor microenvironment in glioblastoma [0.03%]
KITENIN-CCL20轴可能是调节胶质母细胞瘤免疫抑制性肿瘤微环境的潜在治疗靶点
Eun-Jung Ahn,Sung Sun Kim,Sm Abdus Salam et al.
Eun-Jung Ahn et al.
Glioblastoma (GBM) is characterized by an immunosuppressive tumor microenvironment (TME), limiting the effectiveness of existing treatments. We investigated the role of KAI1 COOH-terminal interacting tetraspanin (KITENIN), a metastasis-prom...