Chiral gold nanoparticle synergizes immunometabolic crosstalk and metabolism remodeling for diabetic wound healing [0.03%]
手性金纳米粒子协同免疫代谢信号串话和代谢重构用于糖尿病伤口修复
Huimin Zheng,Xiaowei Wang,Zhengrong Gao et al.
Huimin Zheng et al.
The persistent challenge of diabetic wound healing arises from chronic inflammation, which disrupts the immunometabolic microenvironment. This dysregulated microenvironment exhibits remarkable chirality, but how the stereochemical specifici...
Engineered bacterial outer membrane vesicles enhanced tumor immunotherapy through remodeling tumor stroma and targeted delivery of CD73 siRNA [0.03%]
工程化细菌外膜囊泡通过重塑肿瘤基质和递送CD73 siRNA进行靶向投送到肿瘤中，增强肿瘤免疫治疗
Lili Cheng,Dan Peng,Zhuoyin Liu et al.
Lili Cheng et al.
The dense, hyaluronic acid (HA)-rich extracellular matrix (ECM) within tumor microenvironment (TME) acts as a physical barrier to therapeutic agents and limits immune cell infiltration. Concurrently, the hypoxic condition of TME activates C...
A digitally programmable 3D microenvironment directs satellite cell function [0.03%]
数字化编程的三维微环境指导卫星细胞功能
Shudong Zhao,Lei Wu,Sara Taiyari et al.
Shudong Zhao et al.
Skeletal muscle stem cells, also known as satellite cells, have remarkable self-renewal abilities in response to muscle injury, playing a vital role in muscle regeneration and repair. However, disruptions in the satellite cell niche caused ...
Biomimetic gingival hydrogel promotes the integrated repair of peri-implant gingiva and bone by mobilizing multiple cells [0.03%]
模拟生物牙龈水凝胶通过动员多种细胞促进种植体周围粘膜和骨的联合修复
Tong Zhu,Jingyi Chen,Jiayi Liu et al.
Tong Zhu et al.
During peri-implant bone augmentation surgery, insufficient gingival closure poses significant risks, including bacterial infection and loss of bone repair material, necessitating soft tissue augmentation techniques such as autologous gingi...
In vivo efficacy of an injectable piezoelectric nanocomposite hydrogel and low-intensity pulsed ultrasound in two preclinical models of osteoarthritis [0.03%]
一种可注射压电纳米复合水凝胶和低强度脉冲超声在两种骨关节炎模型中的体内疗效研究
Matilde Tschon,Giorgia Codispoti,Paolo Cabras et al.
Matilde Tschon et al.
Smart hydrogels embedding mesenchymal stromal cells are receiving increasing attention as a potential solution for preventing articular cartilage degeneration in knee osteoarthritis (OA). In this work we demonstrate that an injectable piezo...
Polymer-engineered liposome-delivered Ebselen against tumor through GSH/H2O2-responsive disruption of redox homeostasis and direct p53 activation [0.03%]
基于聚合物工程脂质体递送埃比森治疗肿瘤的策略：通过谷胱甘肽/过氧化氢响应破坏氧化还原平衡和直接激活p53路径
Wenfang Yu,Ting Liu,Zhongwen Yuan et al.
Wenfang Yu et al.
Ebselen (EbSe), an organic selenium-based compound with potential antitumor activity, faces great challenges of poor aqueous solubility, which impairs its bioavailability and exacerbates potential toxicity. Liposomes, as established clinica...
Intracellular small molecule/ion storm from Ca-phytate nanoparticle synergizes neural stem cell therapy and immunomodulation in spinal cord injury [0.03%]
基于Ca-P纳米颗粒的胞内小分子/离子风暴促进神经干细胞治疗和免疫调控修复脊髓损伤
Jiapei Shi,Yanbin Feng,Shuo Zhang et al.
Jiapei Shi et al.
Neural stem cells (NSCs) transplantation offers a promising therapeutic approach for spinal cord injury (SCI), addressing the challenge of neuron irreparability. However, the uncontrolled differentiation of transplanted NSCs and the inflamm...
Targeting ROS-metabolism dual pathways to trigger PANoptosis by cobalt-vanadium oxides biomimetic nanocakes for tumor immunotherapy [0.03%]
靶向ROS-代谢双通路触发PANoptosis的类酶钴钒氧化物纳米片用于肿瘤免疫治疗
Silin Du,Guangyu Ma,Xiang Li et al.
Silin Du et al.
To overcome the resistance of tumor cells to death through a single pathway, PANoptosis, a novel synergistic mode of cell death, can simultaneously activates pyroptosis, apoptosis, and necroptosis. Most current strategies for inducing PANop...
Emerging technologies for personalised oro-maxillofacial bone regeneration: Design strategies and fabrication techniques [0.03%]
个性化口腔颌面骨再生的新兴技术：设计策略与制备方法
Haobo Guo,Qing Li,Hala Zreiqat et al.
Haobo Guo et al.
Oro-maxillofacial bone defects present a major clinical challenge due to the anatomical complexity of the craniofacial skeleton and the limitations of traditional bone grafting, including donor site morbidity and variable outcomes. Personal...
Spontaneous upregulation of stemness and 3D spheroid formation of single cancer cells induced by scaffold-free polypeptide polyelectrolyte multilayer coating [0.03%]
无支架多肽层层组装诱导的单肿瘤细胞自发类器官化及其干性增强机制研究
Jia-Yang Chen,Chia-Chun Liu,Lucas Wang et al.
Jia-Yang Chen et al.
Three-dimensional (3D) cell structures, such as tumor spheroids, have emerged as essential tools in cancer research. However, current scaffold-free planar platforms designed to maintain 3D cell structures, including hydrogel-based low-adher...