Engineered bacterial outer membrane vesicles enhanced tumor immunotherapy through remodeling tumor stroma and targeted delivery of CD73 siRNA
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The dense, hyaluronic acid (HA)-rich extracellular matrix (ECM) within tumor microenvironment (TME) acts as a physical barrier to therapeutic agents and limits immune cell infiltration. Concurrently, the hypoxic condition of TME activates CD73-adenosine axis, ... ...
