Mechanical regulation of m6A-dependent autophagy sustains cancer stemness and chemoresistance in a viscoelastic tumor microenvironment [0.03%]
机械调节m6A依赖性自噬维持凝胶—溶剂肿瘤微环境中的癌症干细胞特性及化学抗性
Yueman Zhang,Chutian Huang,Yuxiao Zhang et al.
Yueman Zhang et al.
The mechanical properties of the tumor microenvironment fundamentally influence cancer progression, while how viscoelastic cues interface with epitranscriptomic regulation to control cell fate remains poorly understood. Here, a pair of hyal...
Paving the way for immunotherapy: Simvastatin-primed dual-targeting NPTAC overcomes immune resistance in hepatocellular carcinoma [0.03%]
免疫疗法的铺路石：西立伐他汀诱导的NPTAC双重靶向治疗克服肝细胞癌免疫抵抗性
Chen Chen,Quanwei Sun,Qiongliu Yu et al.
Chen Chen et al.
Immune checkpoint blockade (ICB)-based regimens, tyrosine kinase inhibitors, and transcatheter arterial chemoembolization (TACE) are major clinical options for unresectable hepatocellular carcinoma (HCC), yet their efficacy remains limited ...
Lizhi Liu,Zhengying Cui,Zihan Zheng et al.
Lizhi Liu et al.
Nanoprobiotic delivery systems have emerged as a promising strategy to improve probiotic stability, functionality, and therapeutic efficacy. In general, nanoprobiotics refer to probiotic formulations integrated with nanoscale or nanoenginee...
Intranasal delivery of engineered macrophage-membrane-coated nanoparticles with enhanced Dectin-1 expression for targeted therapy of cryptococcal meningitis [0.03%]
工程化巨噬细胞膜包被的纳米颗粒鼻内递送治疗隐球菌性脑膜炎研究
Chenghao Liu,Feiyang Geng,Yuhan Liu et al.
Chenghao Liu et al.
Cryptococcal meningitis is a devastating fungal infection of the central nervous system that disproportionately affects immunocompromised individuals and carries high mortality. Amphotericin B (AmB), the clinical gold standard, exhibits pot...
A sonogenetic antigen-presenting nanoplatform enables spatiotemporal control of calcium signalling in T cells for enhanced cancer immunotherapy [0.03%]
一种名为儿子生成抗原呈递纳米平台，能够实现T细胞时空钙信号增强的癌症免疫治疗控制
Qing Zhao,Wushuang Gong,Xuesha Xing et al.
Qing Zhao et al.
Effective T-cell activation plays the critical role in cancer immunotherapy; however, strategies to precisely and sustainably stimulate antitumor T-cell responses while minimizing systemic toxicity remain limited. Here, we develop a sonogen...
GPR110-dependent macrophage polarization mediates the therapeutic effect of V-N3P single-atom catalyst in septic intestinal injury [0.03%]
基于GPR110依赖的巨噬细胞极化的V-N3P单原子催化剂在脓毒性肠损伤治疗中的作用机制研究
Zetian Wang,Chunzheng Liu,Zhiwei Rong et al.
Zetian Wang et al.
Sepsis-induced intestinal injury is driven predominantly by disordered macrophage-mediated inflammatory responses. Vanadium-based single-atom catalysts (V-SACs) have been associated with the alleviation of inflammatory diseases because of t...
Hydrophilic polydopamine (hPDA) fueled bioglue enhances tissue adhesion and promotes healing of avascular meniscus tears [0.03%]
亲水性聚多巴胺生物胶通过增强组织粘附促进膝关节无血管半月板撕裂的修复
Hasan Rafsan Jani,Maya A Jeremias,Aminah T Sarowar et al.
Hasan Rafsan Jani et al.
Avascular meniscus tears exhibit minimal intrinsic healing and frequently progress to joint degeneration because of limited vascularity, poor biological repair capacity, and inadequate restoration of tissue-level mechanical continuity. Here...
In situ bioorthogonal anchoring of stem cells to conductive nanofibrils for enhanced myocardial infarction repair [0.03%]
原位生物正交锚定干细胞至导电纳米纤维用于增强心肌梗死修复
Wei Mao,Jae-Hyun Park,Woo-Sup Sim et al.
Wei Mao et al.
Numerous efforts have been made to recover damaged myocardial infarction tissue with stem cells; however, poor differentiation and low viability of transplanted cells impede effective recovery of cardiac performance. We surface-engineered p...
Oligomerized flavonoid nanointerfaces regulate gastrointestinal nutrient flux and metabolic inflammation [0.03%]
寡聚黄酮纳米界面调节胃肠营养通量和代谢炎症
Tengfei Zhou,Rui Zhang,Li Li et al.
Tengfei Zhou et al.
Oral strategies for obesity and its associated metabolic dysfunction rarely coordinate nutrient digestion, microbial ecology, barrier integrity and low-grade inflammation within the gastrointestinal lumen. Here we report an interface-engine...
Intra-spheroidal BMP-2 delivery in co-cultured spheroids enables concurrent vasculogenesis and osteogenesis in 3D engineered bone constructs [0.03%]
共培养球体内的BMP-2递送可在三维工程骨构建中实现血管生成和成骨的同步进行
Hyunseok Kwon,Sangmin Lee,Eunjin Lee et al.
Hyunseok Kwon et al.
Critical-sized bone defects demand rapid vascularization for graft success, yet conventional pre-vascularization strategies have failed to coordinate vessel formation with osteoinduction. Here, we developed a GelMA-based 3D construct encaps...