Mucosa-penetrating NIR-II nanomedicine for precision photoimmunotherapy of bladder cancer [0.03%]
用于精确光免疫治疗膀胱癌的穿透黏膜的近红外二区纳米药物
Yuxun Ding,Yiqi Zhu,Jiangao Li et al.
Yuxun Ding et al.
Photoimmunotherapy has emerged as a promising modality in cancer treatment, but its effectiveness is limited by inadequate photoagent delivery and inflammation-induced immunosuppression. Herein, we developed an NIR-II-emitting mucosa-penetr...
A coenzyme-based self-stabilized Janus adhesive patch for spatiotemporal regulation of sutureless diabetic tendon healing [0.03%]
一种基于辅酶的自稳定的Janus粘合贴片，用于时空调节无创糖尿病肌腱修复
Chenguang Ouyang,Zhipeng Ni,Haojie Yu et al.
Chenguang Ouyang et al.
Chronic inflammation and adhesion formation severely impede the healing process of diabetic tendons, while current surgical sutures and pharmacological interventions often fail to restore microenvironmental homeostasis. Here, we report a co...
Polyphosphorylcholine-modified liposomes for glioblastoma-targeted siRNA delivery across the blood-brain barrier [0.03%]
用于跨越血脑屏障靶向递送siRNA治疗胶质母细胞瘤的多聚磷酸胆碱修饰脂质体
Muhammad Ismail,Ningyang Wang,Yundong Li et al.
Muhammad Ismail et al.
Liposomes represent versatile drug delivery shuttles in clinics for cancer therapy. Nevertheless, traditional PEG-modified liposomes encounter difficulties, including (1) poor blood-brain barrier (BBB) transcytosis and tumor targeting witho...
Ultrasound-induced nitric oxide release from isosorbide dinitrate nanoparticles for on-demand therapy of periodontitis [0.03%]
用于按需治疗牙周炎的硝酸异山梨酯纳米颗粒的超声诱导一氧化氮释放疗法
Xinchao Wang,Zhilin Liu,Fengli Wu et al.
Xinchao Wang et al.
Nitric oxide (NO) can effectively combat periodontitis by disrupting biofilms and suppressing inflammation; however, its clinical translation has been limited by the lack of a controllable delivery strategy. This study aimed to develop an u...
An immunomodulatory hydrogel encapsulating dental follicle stem cell-derived small extracellular vesicles promotes neutrophil clearance and periodontal bone regeneration [0.03%]
负载牙囊干细胞来源的小细胞外囊泡的免疫调控型水凝胶促进中性粒细胞清除及牙周骨再生
Maoxue Li,Yuqi Wen,Yi Ding et al.
Maoxue Li et al.
Periodontitis, characterized by progressive alveolar bone resorption and periodontal defect formation, remains a major clinical challenge driven by bacterial infection and a dysregulated inflammatory immune microenvironment. Neutrophils, as...
An immunomodulatory hydrogel encapsulating dental follicle stem cell-derived small extracellular vesicles promotes neutrophil clearance and periodontal bone regeneration [0.03%]
负载牙囊干细胞来源的小细胞外囊泡的免疫调控水凝胶促进中性粒细胞清除及牙周骨再生
Maoxue Li,Yuqi Wen,Yi Ding et al.
Maoxue Li et al.
Periodontitis, characterized by progressive alveolar bone resorption and periodontal defect formation, remains a major clinical challenge driven by bacterial infection and a dysregulated inflammatory immune microenvironment. Neutrophils, as...
Nanoscale copper ethoxide enables immunologically enhanced hepatoma radio-immunotherapy via synergistic cuproptosis and metabolic oxidative stress [0.03%]
纳米级铜乙酸盐通过协同杯中毒和代谢氧化应激增强免疫性肝癌放射免疫疗法
Songling Liu,Yang Liu,Qin Fan et al.
Songling Liu et al.
Metal alkoxides hold promise in catalysis and materials science, but their rapid hydrolysis in aqueous media represents a major limitation for biomedical applications. To harness this intrinsic reactivity therapeutically, we developed a fac...
Hydrogel delivery of demineralized bone matrix augmented with ROS-triggered biomineralization and Trb3 activation for enhanced bone regeneration [0.03%]
ROS触发的生物矿化和Trb3激活的脱矿骨基质增强羟胶原蛋白骨再生
Zhi Li,Changlu Xu,Minjee Kang et al.
Zhi Li et al.
Cranial bone defects remain a significant clinical challenge due to limited intrinsic regenerative capacity and an adverse oxidative microenvironment that impairs osteogenesis. Demineralized bone matrix (DBM), a clinically used bone graft s...
Corrigendum to "Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis" [Biomaterials 293 (2023) 121942] [0.03%]
关于“一种通用的仿生纳米酶与多柔比星在电纺丝上的自我增强协同作用，抑制术后肿瘤复发和转移”一文的勘误[Biomaterials 293 (2023) 121942]
Yongwei Hu,Yanteng Xu,Rachel L Mintz et al.
Yongwei Hu et al.
Published Erratum
Biomaterials. 2026 Aug 7:124515. DOI:10.1016/j.biomaterials.2026.124515 2026
Coordination-environment engineering of a sulfur-modified copper single-atom nanozyme enables electronic structure modulation toward systemic antineoplastic therapy [0.03%]
硫修饰铜单原子纳米酶的配位环境工程调控电子结构用于全身抗肿瘤治疗
Weisheng Zhu,Ruonan Li,Xin Luo et al.
Weisheng Zhu et al.
Precise manipulation of atomic coordination environments in single-atom nanozymes offers a powerful strategy to regulate catalytic activity, yet achieving simultaneous enhancement of active-site density and intrinsic catalytic efficiency re...