Intra-spheroidal BMP-2 delivery in co-cultured spheroids enables concurrent vasculogenesis and osteogenesis in 3D engineered bone constructs
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Critical-sized bone defects demand rapid vascularization for graft success, yet conventional pre-vascularization strategies have failed to coordinate vessel formation with osteoinduction. Here, we developed a GelMA-based 3D construct encapsulating co-cultured ... ...
