High-Fat Diet Induces Preeclampsia-Like Phenotypes Associated with Impaired Decidualization and NF-κB Activation [0.03%]
高脂肪饮食诱导与蜕膜化障碍和NF-κB活化相关的子痫前期表型
Miaomiao Zhao,Yanxin Xu,Xingyu Yan et al.
Miaomiao Zhao et al.
Preeclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains a leading cause of maternal-fetal morbidity with unclear pathogenesis. While traditional studies focus on placental dysfunction, the critical role of decidual...
Perinatal walnut-enriched diet partially rescues mitochondrial dysfunction, neuroinflammation, and behavioural deficits induced by developmental manganese exposure [0.03%]
孕期 walnut 富集饮食可部分修复发育期锰暴露引起的线粒体功能障碍、神经炎症和行为缺陷
Tolulope T Arogundade,Ismail Gbadamosi,Aminat Atoyebi et al.
Tolulope T Arogundade et al.
Background: Developmental manganese (Mn) exposure is linked to persistent neurobehavioral deficits, yet dietary mitigation strategies remain underexplored. We tested whether a walnut-enriched diet (WED) administered acros...
Catia Patricia Quadra de Barros,Juliane Azevedo Marrone,Katiani Dos Santos Thereza et al.
Catia Patricia Quadra de Barros et al.
Carnosic acid (CA), a phenolic diterpene abundant in Rosmarinus officinalis, has emerged as a bioactive compound with multifaceted effects on hepatic cells and liver tissue. The present work aims to critically discuss, from a mechanistic pe...
Early-onset PUFA deficiency exacerbates lean MAFLD-like hepatic injury in FADS2 knockout mice [0.03%]
早期PUFA缺乏可加剧FADS2敲除小鼠肝脂蓄积所致的瘦型MAFLD样肝脏损伤
Yuri Hayashi,Natuki Matsuoka,Yukina Yoshimoto et al.
Yuri Hayashi et al.
Polyunsaturated fatty acids (PUFAs) are vital for maintaining health, particularly during infancy and early childhood. In this study, we examined PUFA deficiency in FADS2 knockout (KO) mice, which lack endogenous synthesis of PUFAs with ≥2...
Fasting-mimicking diet moderates myocardial ischemia/reperfusion injury through the PCBP2-ACSL4 regulatory axis in ferroptosis [0.03%]
模拟禁食饮食通过PCBP2-ACSL4调控轴调节铁死亡中的心肌缺血/再灌注损伤
Ruijuan Han,Jianan Xie,Shanshan Zhou et al.
Ruijuan Han et al.
Background: Myocardial ischemia/reperfusion (I/R) injury is a major contributor to coronary heart disease. Fasting has emerged as a cardioprotective intervention, yet the underlying mechanisms are unclear. Ferroptosis, an...
Pterostilbene targets microglia-mediated neuroinflammation for Alzheimer therapy [0.03%]
白藜芦醇通过靶向微胶质细胞介导的神经炎症用于阿尔茨海默症治疗
Feichi Chen,Xinhuang Lv,Kun Xiang et al.
Feichi Chen et al.
Microglia-mediated neuroinflammation is a key driver of Alzheimer's disease (AD) progression, exacerbating neuronal damage and pathological changes. Pterostilbene (PTE), a natural anti-inflammatory stilbenoid, shows neuroprotective potentia...
Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2 [0.03%]
黄芩素通过诱导Nrf2激活代谢性活化脂肪组织巨噬细胞来缓解西方饮食引起的肥胖症状
Siyi Zhang,Shanyue Yang,Bingxuan Kong et al.
Siyi Zhang et al.
Western diet (WD)-induced obesity is closely associated with dysfunctional adipose tissue macrophages (ATMs), particularly the metabolically activated macrophages (MMe) and the impairment of lysosomal function. Baicalein, a natural flavonoi...
Effects and Mechanisms of Nobiletin on Gut Motility by Coordinating Bile Acid Signaling via Dual Ileal-Colonic Axes in STC Model Mice [0.03%]
诺柏亭通过双回肠轴协调胆汁酸信号对STC模型小鼠胃肠道运动的效应及机制研究
Dingli Wang,Huilin Zhu,Hui Zhou et al.
Dingli Wang et al.
Slow transit constipation (STC) is a functional gastrointestinal disorder with complex etiology and limited therapeutic options. Nobiletin (NOB), a natural polymethoxyflavone derived from citrus, exhibits multiple pharmacological activities...
Therapeutic potential of wogonoside in hypertension-induced cardiac injury: Targeting apoptosis and MAPK signaling pathway [0.03%]
姜黄素类似物wogonoside治疗高血压诱导的心脏损伤的潜在机制：靶向细胞凋亡和MAPK信号通路作用研究
Hong Chen,Shu Lin,Meizhu Wu et al.
Hong Chen et al.
Background: Hypertension caused cardiomyocyte apoptosis and remodeling, leading to heart failure. Wogonoside (WOG), a flavonoid from Qingda granules, was evaluated for cardioprotective effects and mechanisms. ...
Naringenin ameliorate heat stress induced hearts injury by regulating ferroptosis and ferritinophagy in chicken [0.03%]
芸香素通过调节铁死亡和 ferritinhagy 改善鸡的热应激诱导的心脏损伤
Jiahao Fang,Zhenpeng Jiang,Jingyan Luo et al.
Jiahao Fang et al.
Intensive farming and global warming exacerbate the impact of heat stress on the broiler industry, often causing significant heart damage to poultry and thus reducing production performance. Naringenin has garnered significant attention due...