High-fat diet and age disrupt a Muribaculaceae-associated SCFA network linked to gut barrier and cognitive deficits [0.03%]
高脂饮食和年龄破坏与肠道屏障和认知缺陷相关的Muribaculaceae短链脂肪酸网络
Ning Wang,Jianlei Bi,Xiaoying Dong et al.
Ning Wang et al.
Both diet and aging shape the gut microbiota, yet how their combined remodeling propagates across microbial function to host barrier and brain outcomes remains poorly understood. Despite abundant links between Short-chain fatty acids (SCFAs...
miR-1a-3p impairs β-cell function in male offspring via disrupted NBR1-dependent mitochondrial function but not apoptosis after maternal high-saturated-fat diet in mice [0.03%]
母鼠高饱和脂肪饮食通过干扰NBR1依赖性线粒体功能而不是凋亡影响雄性后代小鼠胰岛β细胞功能的miR-1a-3p作用机制研究
Chenchen Geng,Yansong Zhang,Jiaxin Zhao et al.
Chenchen Geng et al.
Early-life maternal high-saturated fat (HSF) exposure increases offspring susceptibility to type 2 diabetes, but mechanisms linking it to β-cell dysfunction remain poorly defined. This study aimed to identify key miRNAs mediating this prog...
Effects of phytosterols supplementation on hepatic lipid metabolism and metabolic outcomes in obese rodent models: A systematic review and meta-analysis [0.03%]
植物甾醇补充对肥胖啮齿动物模型肝脂代谢和代谢结局的影响：系统评价和meta分析
Juliana Silva Siqueira,Larissa Lopes da Cruz,Thiago Luiz Novaga Palacio et al.
Juliana Silva Siqueira et al.
This study aimed to synthesize and quantitatively assess the available evidence on the effects of phytosterol supplementation on hepatic lipid metabolism and obesity-related metabolic outcomes in obese rodent models, integrating biochemical...
Highly expressed ACSF2 contributes to butyrate utilization in the rumen epithelium [0.03%]
ACSF2高表达促进瘤胃上皮组织丁酸的利用
Mingmei Song,Jing Qin,Junru Tian et al.
Mingmei Song et al.
Ruminant epithelia preferentially catabolize butyrate to fuel metabolism, yet the mechanism by which the rumen epithelium establishes this preference remains unclear. Here, we identify ACSF2 as a mitochondrial acyl‑CoA synthetase (ACS) tha...
Study on the Role of Cyanidin-3‑O‑galactoside in Alleviating Pulmonary Fibrosis via Ccl3/Slc2a3 [0.03%]
cyanidin-3-O-半乳糖苷通过Ccl3/S lc2a3减轻肺纤维化的作用机制研究
Xian Tang,Meng Zhao,Fei Li et al.
Xian Tang et al.
Cyanidin-3-O-galactoside(C3G) has a variety of biological activities. Pulmonary fibrosis (PF) is a fatal interstitial lung disease. To define its pathogenic networks, we performed transcriptomic sequencing of lung tissues from five mouse gr...
Eicosatrienoic acid improves PCOS in mice by modulating the intestinal barrier and ovarian inflammation [0.03%]
二十碳三烯酸通过调节肠道屏障和卵巢炎症改善小鼠PCOS
Jin Yan,Shao-Zhuang Ma,Shuang-Yan Chang et al.
Jin Yan et al.
Polycystic ovary syndrome (PCOS) is a prevalent metabolic and endocrine disorder marked by hormonal imbalances among women, and the specific pathogenesis remains incompletely clarified. Although n-3 polyunsaturated fatty acids (n-3 PUFAs) h...
Dietary L-Malic Acid Supplementation during Early Pregnancy Improves Reproductive Performance through Modulation of Antioxidant Capacity and the Gut Microbiota-Metabolite Axis in Sows [0.03%]
妊娠早期补饲L-苹果酸通过调节抗氧化能力及母猪肠道菌群-代谢物轴改善繁殖性能
Xiaoyi Zhao,Xiaolong Wang,Qian Ma et al.
Xiaoyi Zhao et al.
Embryo loss during early pregnancy is a major constraint on mammalian reproductive efficiency. We previously revealed that dietary L-malic acid (L-MA) supplementation benefits maternal health in sows during late pregnancy. However, the effe...
Alternate-Day Fasting Enhances Leptin Sensitivity via JMJD3-Dependent Epigenetic Regulation of the Leptin Receptor in the Hypothalamus [0.03%]
间歇性断食通过组蛋白去甲基化酶JMJD3介导的表观遗传修饰改善下丘脑瘦素受体敏感性及促进肥胖患者体重减轻
Busayo Oladun,Smita Mall,Baochan Fan et al.
Busayo Oladun et al.
Leptin resistance is a hallmark of obesity. It is characterized by diminished responsiveness to leptin and disrupts energy homeostasis. While multiple pathways contribute to leptin resistance, the transcriptional repression of the leptin re...
Choline insufficiency in mothers during gestation abolishes the metabolically restrained hepatic phenotype induced by gestational protein restriction and promotes hepatic steatosis in offspring [0.03%]
孕期母亲胆碱不足破坏了妊娠期蛋白质限制诱导的代谢抑制性肝表型并促进子代发生肝脂肪变性
Tomoka Aizawa,Shiori Ishiyama,Takashi Nakamura et al.
Tomoka Aizawa et al.
Maternal protein restriction during gestation in rodents is widely used as a model of developmental programming; however, its metabolic effects in offspring are often modest. In humans, protein deficiency is frequently accompanied by defici...
Chebulinic Acid Restores Glycolytic Reprogramming and Mitochondrial Dysfunction in MASLD via Modulation of Lp-PLA2 Signaling [0.03%]
没食子酸通过调节Lp-PLA2信号恢复MASLD中的糖酵解重建和线粒体功能障碍
Yinghui Wang,Guochun Zhang,Xicheng Jiang et al.
Yinghui Wang et al.
Metabolic dysfunction-associated fatty liver disease (MASLD) is a major global health challenge characterized by metabolic imbalance, inflammation, and oxidative stress, yet effective targeted therapies remain limited. Lipoprotein-associate...