Inhibition of the CYP2E1-19-HETE-BLT2-mediated oxidative injury amplification by FGF21 alleviates myocardial infarction remodeling [0.03%]
FGF21通过抑制CYP2E1-19-HETE-BLT2介导的氧化损伤放大缓解心梗重构
Guangsen Xu,Guiyun Wang,Yihan Fang et al.
Guangsen Xu et al.
The arachidonic acid (AA) metabolic cascade plays important roles across multiple pathological conditions; however, the contribution of AA-derived lipid metabolism to myocardial infarction (MI) remains incompletely understood. Here, we comb...
Modulating hepatic hypoxanthine metabolism relieve metabolic stress-related neurovascular resilience disturbance via the liver-brain axis [0.03%]
通过肝脑轴调节肝脏次黄嘌呤代谢可缓解与代谢压力相关的神经血管适应性紊乱
Huifang Tu,Yunlong Hou,Wenwen Cui et al.
Huifang Tu et al.
Background: Unhealthy lifestyles promote brain aging, but their mechanisms remain unclear. The liver-brain axis acts as a key mediator of brain dysfunction and warrants investigation in lifestyle-induced brain aging. ...
GPX3 downregulation in alveolar macrophages amplifies IL-17-dependent redox-inflammation crosstalk in ARDS [0.03%]
肺泡巨噬细胞中GPX3下调加剧了ARDS中IL-17依赖性的氧化-炎症相互作用
Yi Lv,Ying Lin,Ling Zheng et al.
Yi Lv et al.
Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition in which bidirectional amplification between oxidative stress and inflammation critically drives disease progression. However, the cel...
DANGER/ITPRIP-mediated iron homeostasis mediates ferroptosis resistance and presents a potential therapeutic target in ccRCC [0.03%]
危险/DANGER/ITPRIP介导的铁稳态调节对ccRCC细胞肺泡型红细胞增多症耐受的作用及作为潜在治疗靶点的可能性研究
Kerui Fan,Yuxin Zhou,Jiaxin Xu et al.
Kerui Fan et al.
Clear cell renal cell carcinoma (ccRCC) exhibits unique metabolic reprogramming characterized by disrupted iron homeostasis, primarily due to inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. This iron dysregulation creates...
Resveratrol exerts anti-aging effects in young but pro-aging effects in middle-aged C. elegans via a gerosuppressive daf-16/dod-6/sod-3 axis [0.03%]
白藜芦醇通过抑衰轴在年轻秀丽隐杆线虫中发挥抗衰老作用，但在年老个体中促进衰老
Mei-Ling Ou,Jin-Xiong Cen,Cao-Yan Qi et al.
Mei-Ling Ou et al.
Aging, a complex process influenced by genetic and environmental factors, is a major determinant of health and disease. The polyphenolic compound resveratrol, known for its antioxidant properties, has been widely studied for its potential a...
Redox-dependent mitochondrial dynamics: PLK1 couples glutathione metabolism to ROS-driven JNK and DUSP6 pathways in colorectal cancer [0.03%]
抗氧化还原依赖的线粒体动力学：PLK1在结直肠癌中将谷胱甘肽代谢与活性氧驱动的JNK和DUSP6通路相偶联
Yan Li,Lili Zhao,Zhiyun Xu et al.
Yan Li et al.
Polo-like protein kinase 1 (PLK1) is aberrantly overexpressed in colorectal cancer (CRC) and promotes malignant progression. However, whether PLK1 contributes to redox adaptation remains unclear. Here, we identify PLK1 as a critical hub tha...
Lactate reprogramming hijacks BDNF neuroprotection to drive hippocampal injury after CO poisoning [0.03%]
乳酸重新编程劫持BDNF神经保护作用促进一氧化碳中毒后的海马损伤
Shijun Yang,Shanshan Li,Jie Xiang et al.
Shijun Yang et al.
Carbon monoxide (CO) poisoning is a leading cause of neurological injury, yet the underlying metabolic-neurotrophic mechanisms remain unclear. Through pre-clinical experiments, we integrated glycolytic metabolomics with single-cell RNA sequ...
Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS-DLAT axis and promoting M2 macrophage polarization [0.03%]
尼古丁通过抑制LIAS-DLAT轴介导的铜死亡并促进M2型巨噬细胞极化来驱动肺癌进展
Yi-Fang Yang,Min-Hsi Lin,Yu-Yu Lin et al.
Yi-Fang Yang et al.
Cuproptosis is a recently defined, copper-dependent, regulated cell death pathway characterized by the aggregation of lipoylated mitochondrial enzymes; however, the mechanisms by which lung cancer cells evade this process under environmenta...
BAIBA attenuates pulmonary fibrosis by modulating the iron/ROS-mitochondrion-apoptosis cascade [0.03%]
BAIBA通过调节铁/ROS-线粒体-凋亡级联反应来缓解肺纤维化
Chaoqi Du,Jiahui Wang,Xiaofan Wang et al.
Chaoqi Du et al.
Pulmonary fibrosis (PF) is a chronic and progressive lung disease with limited therapeutic options. Beta-aminoisobutyric acid (BAIBA), a muscle-derived metabolite, has been reported to regulate metabolism and oxidative stress, but its poten...
Liver-derived, circulating xanthine oxidoreductase drives vascular impairment associated with inhalation of ultrafine particulates [0.03%]
吸入超细颗粒物相关的肝脏衍生的血循环黄嘌呤氧化还原酶诱导血管功能障碍
Xena M Williams,Alec T Bossert,Maddison Seman et al.
Xena M Williams et al.
Inhalation of ultrafine particles (UFP) mediates systemic vascular impairment which is, in part, driven by elevated rates of oxidant generation. One significant source of oxidant production in the vascular compartment is the purine cataboli...