DANGER/ITPRIP-mediated iron homeostasis mediates ferroptosis resistance and presents a potential therapeutic target in ccRCC
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Clear cell renal cell carcinoma (ccRCC) exhibits unique metabolic reprogramming characterized by disrupted iron homeostasis, primarily due to inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. This iron dysregulation creates a therapeutic oppor... ...
