Thymus-derived myeloid programs track microglial tolerance states across human cohorts [0.03%]
人队列中胸腺衍生的髓系程序跟踪小胶质细胞耐受状态
Sanwal Ahmad Zafar,Wei Qin,Liu Chengliang et al.
Sanwal Ahmad Zafar et al.
Introduction: Microglial functional positioning varies across individuals and disease contexts, yet conserved biological axes supporting reproducible cross-cohort inference remain poorly defined. Intrathymic T cell develo...
Non-pharmacological interventions modulating immune response in Parkinson's Disease: where do we stand for future preventive approaches [0.03%]
非药物干预在帕金森病免疫反应中的作用：未来预防措施的方向在哪里？
Elenamaria Pirovano,Inês P Silva,Marta Camacho et al.
Elenamaria Pirovano et al.
Parkinson's disease (PD) imposes a growing socioeconomic burden due to its increasing prevalence and lack of a cure. Existing treatment options primarily manage motor and nonmotor symptoms but do not halt or slow disease progression, unders...
Allopregnanolone reduces the blocking properties of competitive antagonists of GABA(A) receptor [0.03%]
allopregnanolone减少GABA(A)受体竞争性拮抗剂的阻断作用
Rodion V Kondratenko,Julia V Bukanova,Elena I Solntseva
Rodion V Kondratenko
The orthosteric site of the GABAA receptor binds both the agonist (GABA) and the competitive antagonists bicuculline (Bic) and gabazine (GBZ). The endogenous neurosteroid allopregnanolone (Allo) is known to alter the conformation of the ort...
Glial High-Mobility Group Box 1 Translocation Promotes Post-Stroke Epileptic Seizures [0.03%]
胶质高迁移率族箱蛋白1转位促进中风后癫痫发作
Chao Zhong,Wenqi Wang,Jinghong Li et al.
Chao Zhong et al.
Post-stroke epilepsy (PSE) is a common type of epilepsy, often refractory to conventional pharmacological interventions. In the present study, we investigate the role of high mobility group box 1 (HMGB1) in PSE and evaluate therapeutic effi...
Mild Traumatic Brain Injury Produces Persistent Wake-State Instability and EEG Slowing Despite Carbon Monoxide Neuroprotection [0.03%]
一氧化碳神经保护无法改善脑外伤后持续的觉醒状态不稳定及脑电活动减慢现象
Rebecca Y Broadhurst,Vanessa A Voltarelli,Janick Weber et al.
Rebecca Y Broadhurst et al.
Individuals who experience mild traumatic brain injury (mTBI) frequently report persistent sleep-wake disturbances that impair daytime function and recovery. However, the physiological nature of these disturbances remains incompletely under...
Tanshinone IIA alleviates cerebral ischemia-reperfusion injury by inhibiting pyroptosis: involvement of the KLF4/CHIP/NLRP3 pathway [0.03%]
丹参酮 ⅡA通过KLF4/CHIP/NLRP3信号通路抑制神经元焦亡从而减轻缺血再灌注脑损伤
Zhenzhen Zhong,Zhilin Huang,Zhaoping Wu et al.
Zhenzhen Zhong et al.
Cerebral ischemia/reperfusion injury (CI/RI) is a critical pathological process in ischemic stroke. Pyroptosis plays a central role in the development of CI/RI. NOD-like receptor protein 3 (NLRP3) inflammasome is a key initiator of pyroptos...
Attenuating effects of heat-processed Panax ginseng (Red and Black) on methamphetamine-induced behaviors via dopaminergic modulation [0.03%]
热处理红参和黑参通过多巴胺能调节缓解麻黄素诱导的行为异常的保护作用
Chul Kyu Lee,Sun Mi Gu,Bongjun Kim et al.
Chul Kyu Lee et al.
Methamphetamine (METH) is one of the most widely used psychostimulants associated with substance use disorders. Korean red ginseng extract (RGE), produced by the single steaming process of Panax ginseng, has been reported to inhibit drug-in...
Mesenchymal Stem Cell Secretome Attenuates Disease-Associated Microglial Activation and Cognitive Decline in TBI-Associated Neuroinflammation [0.03%]
间充质干细胞分泌组减轻TBI相关神经炎症中的疾病相关小胶质细胞激活和认知衰退
Pratheepa Kumari Rasiah,Saifudeen Ismael,Sally Elshaer et al.
Pratheepa Kumari Rasiah et al.
Therapeutic options for traumatic brain injury (TBI) remain limited, in part due to injury-induced activation of microglia toward disease-associated microglia (DAM) phenotypes that contribute to persistent neuroinflammation and cognitive de...
Cordycepin alleviates aluminium chloride-induced neurodevelopmental toxicity in zebrafish embryos by modulating inflammation and Wnt signaling [0.03%]
虫草素通过调控炎症和Wnt信号通路缓解铝氯诱导的斑马鱼胚胎神经发育毒性
Hongmei Hu,Guanghua Xiong,Fasheng Liu et al.
Hongmei Hu et al.
Background: Cordycepin, a major bioactive constituent of Cordyceps militaris, exhibits diverse pharmacological properties including anti-inflammatory and antioxidant activities. However, its neuroprotective effects agains...
PPARα Activation with Fenofibrate Confers Hippocampal Neuroprotection but Lacks Disease-Modifying Efficacy in Chronic Temporal Lobe Epilepsy [0.03%]
PPARα激活剂fenofibrate对慢性颞叶癫痫海马具神经保护作用但不能改善疾病进程
Olga E Zubareva,Tigran B Melik-Kasumov,Denis S Sinyak et al.
Olga E Zubareva et al.
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effect...