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Tanshinone IIA alleviates cerebral ischemia-reperfusion injury by inhibiting pyroptosis: involvement of the KLF4/CHIP/NLRP3 pathway

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Cerebral ischemia/reperfusion injury (CI/RI) is a critical pathological process in ischemic stroke. Pyroptosis plays a central role in the development of CI/RI. NOD-like receptor protein 3 (NLRP3) inflammasome is a key initiator of pyroptosis and is associated... ...