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PPARα Activation with Fenofibrate Confers Hippocampal Neuroprotection but Lacks Disease-Modifying Efficacy in Chronic Temporal Lobe Epilepsy

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Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects in the chronic pha... ...