Allopregnanolone reduces the blocking properties of competitive antagonists of GABA(A) receptor
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The orthosteric site of the GABAA receptor binds both the agonist (GABA) and the competitive antagonists bicuculline (Bic) and gabazine (GBZ). The endogenous neurosteroid allopregnanolone (Allo) is known to alter the conformation of the orthosteric site of the... ...
