Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice [0.03%]
Ornithine decarboxylase缺乏的利什曼原虫通过口腔感染补充Putrescine恢复致病性
Tamara Olenyik,Caslin Gilroy,Buddy Ullman
Tamara Olenyik
Administration of putrescine as a 1% solution in the drinking water ameliorated the profound loss of virulence exhibited by ornithine decarboxylase (ODC) deficient Leishmania donovani in mice. Furthermore, supplying α-difluoromethylornithi...
A novel dual Dbp5/DDX19 homologue from Plasmodium falciparum requires Q motif for activity [0.03%]
一个新的来自恶性疟原虫的双Dbp5/DDX19同源物需要Q配基以发挥活性
Jatin Mehta,Renu Tuteja
Jatin Mehta
Helicases are ubiquitous essential enzymes which have significant role in the nucleic acid metabolism. Using in silico approaches in the recent past we have identified a number of helicases in the Plasmodium falciparum genome. In the presen...
Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae [0.03%]
人工线性表载体蛋白表达系统在原生动物Leishmania tarentolae中的应用
Susanna Kushnir,Ion Cristian Cirstea,Lyudmyla Basiliya et al.
Susanna Kushnir et al.
The trypanosomatid protozoon Leishmania tarentolae is a well-established model organism for studying causative agents of several tropical diseases that was more recently developed as a host for recombinant protein production. Although sever...
Glutamate-mediated signaling in Schistosoma mansoni: a novel glutamate receptor is expressed in neurons and the female reproductive tract [0.03%]
日本血吸虫谷氨酸受体及其在神经元及雌性生殖系统中的表达研究
Amira Taman,Paula Ribeiro
Amira Taman
l-Glutamate is a major neurotransmitter of both vertebrates and invertebrates. Earlier studies have shown that glutamate stimulates neuromuscular activity in the bloodfluke, Schistosoma mansoni, but its mode of action is unknown. Here we de...
The Apicomplexan AP2 family: integral factors regulating Plasmodium development [0.03%]
逐粒无隔孢子虫AP2家族：调控疟原虫发育的整合因子
Heather J Painter,Tracey L Campbell,Manuel Llinás
Heather J Painter
Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of multiple hosts and cell types during the course of an infection. To complete its complex life cycle the parasite requires strict control of gene regu...
María José López-Barragán,Mariam Quiñones,Kairong Cui et al.
María José López-Barragán et al.
The DNA amplification process can be a source of bias and artifacts, especially when amplifying genomic areas with extreme AT or GC content. The human malaria parasite Plasmodium falciparum has an AT-rich genome, and some of its highly AT-r...
The role of polymorphisms in the spliced leader addition domain in determining promoter activity in Brugia malayi [0.03%]
布氏马来丝虫体内拼接领导人位点单核苷酸多态性对启动子活性的影响
Michelle Bailey,Chitra Chauhan,Canhui Liu et al.
Michelle Bailey et al.
Previous studies of Brugia malayi promoters have suggested that they are unusual in that they lack the CAAT or TATAA boxes that are often emblematic of eucaryotic core promoter domains. Instead, the region surrounding the spliced leader (SL...
The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties [0.03%]
四个夜蛾科eIF4E同源物分为两大类，其一级序列和生物学特性各不相同
Eden R Freire,Rafael Dhalia,Danielle M N Moura et al.
Eden R Freire et al.
Translation initiation in eukaryotes requires eIF4E, the cap binding protein, which mediates its function through an interaction with the scaffolding protein eIF4G, as part of the eIF4F complex. In trypanosomatids, four eIF4E homologues hav...
Developmental expression of high molecular weight tropomyosin isoforms in Mesocestoides corti [0.03%]
Mesocestoides corti个体发育过程中高分子量的肌动蛋白表达分析
Uriel Koziol,Alicia Costábile,María Fernanda Domínguez et al.
Uriel Koziol et al.
Tropomyosins are a family of actin-binding proteins with diverse roles in actin filament function. One of the best characterized roles is the regulation of muscle contraction. Tropomyosin isoforms can be generated from different genes, and ...
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6 [0.03%]
基因组范围的RNA干扰筛选在非洲锥虫中鉴定出硝呋莫司活化剂NTR和甲氟喹转运体AAT6
Nicola Baker,Sam Alsford,David Horn
Nicola Baker
To be effective, therapeutic compounds must typically enter target cells and, in some cases, must be concentrated or modified. Thus, uptake and activation mechanisms often form the basis of selectivity against infectious agents. Loss-of-fun...