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Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice

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Administration of putrescine as a 1% solution in the drinking water ameliorated the profound loss of virulence exhibited by ornithine decarboxylase (ODC) deficient Leishmania donovani in mice. Furthermore, supplying α-difluoromethylornithine, an ODC inhibitor... ...