Identification of vulnerable antimalarial targets using conditional loss of function mutants [0.03%]
利用条件性功能丧失突变体识别抗疟疾药物的脆弱靶点
Philip J Shaw,Parichat Prommana,Chayaphat Wongsombat et al.
Philip J Shaw et al.
To counter the threat of drug-resistant malaria parasites, drug discovery efforts should be focused on compounds with novel modes of action. Furthermore, drug candidates acting on vulnerable targets should be triaged as they are most likely...
Optimising Electroporation Protocols for Trypanosoma brucei Using the Amaxa 4D- Nucleofector System [0.03%]
使用Amaxa 4D-nucleofector系统优化吉斯特锥虫电转化条件的研究
Caroline E Dewar,Elizabeth F B King,Federico Rojas
Caroline E Dewar
Stable transfection of Trypanosoma brucei remains a cornerstone for functional genetic studies in this model parasite. Although the Amaxa Nucleofector II system dramatically improved transfection efficiency in both monomorphic and pleomorph...
Why not now? Targeting Plasmodium falciparum histone methyltransferases for next-generation antimalarial strategies [0.03%]
为何不现在？针对疟原虫组蛋白甲基转移酶的下一代抗疟新策略
Ezhumalai Parthiban,Ravichandran Ramanibai,Maduraiveeran Ramachandran
Ezhumalai Parthiban
Plasmodium falciparum is the major human malaria parasite and its treatment remains challenging, with current artemisinin-based combination therapies increasingly compromised by emerging resistance in several regions. Although the pre-eryth...
Modulatory Role of Blastocystis-Derived Solubilized Antigens in Colorectal Carcinogenesis: A Systematic Review [0.03%]
巴约塔体来源的溶解抗原在结直肠癌发生发展中的调节作用：系统综述
Nur Amani Syakirin Noor Razali,Nur Anurah Hani Mohd Akmal,Nur Eisya Wardina Mohd Khir et al.
Nur Amani Syakirin Noor Razali et al.
Colorectal cancer develops through complex interactions between genetic alterations, immune responses, and the intestinal microenvironment. Increasing evidence suggests that intestinal parasites may also contribute to colorectal carcinogene...
Structural basis for the inhibition of Trypanosoma brucei enolase by a camelid single-domain antibody [0.03%]
骆驼单域抗体抑制布氏锥虫烯醇化酶的结构基础
Zeng Li,Natalia Smiejkowska,Julie Vansevenant et al.
Zeng Li et al.
Trypanosoma brucei is an extracellular protozoan that causes neglected tropical diseases in both humans and livestock. The parasite has a bipartite life cycle involving an insect vector and a mammalian host. Within the latter, it mainly thr...
Cloning-based analysis of MHC class II DRB variation and Enterocytozoon bieneusi association in the Amur tiger (Panthera tigris altaica) [0.03%]
基于克隆的虎II类主要组织相容性复合体DRB变异和生物须利什曼原虫关联分析
Yang Liu,Haitao Xu,Yu Zhang et al.
Yang Liu et al.
The polymorphism of major histocompatibility complex (MHC) class II classical genes is closely related to pathogen resistance, among which the second exon of the DRB gene has the highest variability. In this study, we analyzed exon 2 of the...
Ethyl acetate extract from Dinizia excelsa Ducke wood: a potential phytotherapeutic agent with antioxidant, cytotoxic and hemolytic (in normal cells), immunomodulatory, antimicrobial, antiparasitic and antitumor activities [0.03%]
迪尼扎木的乙酸乙酯提取物：一种潜在的具有抗氧化，细胞毒和溶血（正常细胞），免疫调节，抗菌，抗寄生虫和抗肿瘤作用的植物药剂
Carolina Ávila Dos Anjos Santos,Arthur Van Lauter Albuquerque Pereira,Karla Crystina Costa Dos Santos et al.
Carolina Ávila Dos Anjos Santos et al.
Amazonian biodiversity is an underexploited source of bioactive natural products with potential relevance to drug discovery for neglected diseases. Here, we characterized the chemistry and multi-target in vitro activity of an ethyl acetate ...
Plasmodium falciparum invasion ligand gene transcript profiles in different populations [0.03%]
恶性疟原虫侵袭受体基因转录本的种类和数量差异性研究
Elena Lantero-Escolar,Lindsay B Stewart,Balbir Singh et al.
Elena Lantero-Escolar et al.
Plasmodium falciparum merozoites invade erythrocytes using various ligand-receptor interactions. Important ligands encoded by the eba and Rh gene families have varying expression levels in different parasite isolates, affecting their vaccin...
Exploring the Warburg effect in Chagas disease: a biochemical approach to metabolic reprogramming [0.03%]
查加斯病中瓦伯格效应的探索：代谢重编程序的生化方法
Claudia Santos,Veronica Zandona,Flavia Bonamin et al.
Claudia Santos et al.
Chagas disease (CD), caused by Trypanosoma cruzi, is a significant problem of public health. The infection induces inflammatory processes in tissues, leading to metabolic changes similar to the Warburg Effect (WE). To evaluate the presence ...
Stage-specific differential gene expression leads to adaptive changes in the promastigote and amastigote stages of Leishmania donovani [0.03%]
利什曼原虫Donovani小杆虫期和无鞭毛体期阶段特异性差异基因表达导致的适应性变化
Ishana Jha,Basant K Tiwary
Ishana Jha
Leishmania donovani exists in two distinct environments to complete its life cycle. It exists as a non-motile infective amastigote state in humans and as a motile promastigote state in the sandfly gut. Although the differences in gene expre...