Doxorubicin-induced damage to AC16 cardiomyocytes and attenuation by human pericardial fluid Sca-1+/Nanog+ cells conditioned medium: a pilot study [0.03%]
多柔比星诱导AC16心肌细胞损伤及人滑膜Sca-1+/Nanog+细胞条件培养基的干预作用：一项初步研究
Jingxian Han,Lei Hua,Siqi Zhang et al.
Jingxian Han et al.
Background: Heart failure (HF) remains a leading cause of death worldwide. Stem cells represent a promising strategy for myocardial regeneration due to their differentiation potential and paracrine effects. This study inv...
Emerging molecular mechanism of neuroinflammation in Parkinson's disease: A JAK/STAT and TGFβ/SMAD signaling crosstalk [0.03%]
帕金森病中神经炎症新兴分子机制：JAK/STAT和TGFβ/SMAD信号通路相互作用
Kaustav Purkayastha,Abhideep Roy,Pallab Bhattacharya et al.
Kaustav Purkayastha et al.
Neuroinflammation has emerged as a convergent pathological signature of Parkinson's disease (PD), shaping both its onset and progression. Persistent activation of glial cells, driven by elevated proinflammatory cytokines, creates a self-rei...
Bifid triple viable tablets are associated with renal biochemical improvement and qualitative gastrointestinal changes in 5/6-nephrectomized rats: An exploratory microbiome-metabolome study [0.03%]
双歧三联活菌片通过改变肠道菌群改善肾功能并促进肾脏代谢物变化：初步研究
Jiamei Di,Jintang Hu,Feng Zhao et al.
Jiamei Di et al.
Background: Chronic kidney disease (CKD) is accompanied by renal injury, gut-barrier disruption, dysbiosis, inflammation, and disordered iron regulation. We examined whether a clinical multi-strain probiotic produces coor...
Critical role of Asp283 in modulating calcium-dependent autoprocessing of yeast Metacaspase ScMCA-Ia [0.03%]
天冬氨酸283在调节酿酒酵母半胱天冬酶ScMCA-Ia钙依赖性自动加工过程中的关键作用
Mariana Nascimento Romero Trujilho,Laura de Azevedo Maffeis Dalzoto,Taiz Dos Reis Santos et al.
Mariana Nascimento Romero Trujilho et al.
Metacaspases are Ca2+-dependent cysteine proteases essential for programmed cell death. This study elucidates the regulatory mechanisms of Saccharomyces cerevisiae type I metacaspase (ScMCA-IA), focusing on Ca2+-dependent autoprocessing and...
Fosl2/c-Jun dimer induces oxidative stress and endoplasmic reticulum stress by enhancing Lcn2 transcription to promote ischemic cerebral infarction [0.03%]
Fosl2/c-Jun二聚体通过增强Lcn2转录诱导氧化应激和内质网应激以促进缺血性脑梗死
Qi Zhang,Jing Jin,Jianxiu Wang
Qi Zhang
Objective: Ischemic cerebral infarction (ICI) results in high disability and mortality rates. This study aims to validate that the Fosl2/c-Jun dimer promotes ICI via the transcriptional activation of Lcn2. ...
Superparamagnetic iron oxide nanoparticles platforms: Recent trends in cancer treatment [0.03%]
超顺磁性铁氧化物纳米颗粒平台：癌症治疗的最新趋势
Sujan Roy,Rakesh Ghosh,Mita Rani Chanda et al.
Sujan Roy et al.
Disadvantages associated with using antidotes for certain diseases include nonspecificity, undesirable safety profiles, and side effects. For clinical use, additional characteristics such as uneven biodistribution, instability, and rapid de...
Innovative approaches in the therapeutic application of EpCAM aptamer for targeted Cancer treatment: A review [0.03%]
靶向癌症治疗的EpCAM适配体疗法创新应用：综述
Mohammad Hossein Hosseinzadeh,Monireh Askarzadeh,Pedram Ebrahimnejad et al.
Mohammad Hossein Hosseinzadeh et al.
The development of targeted therapies has revolutionized cancer treatment by improving the specificity and efficacy of therapeutic options. Aptamers, short single-stranded nucleic acids, have emerged as a promising class of molecules for ta...
Evolutionary divergence of dipeptidyl-peptidase (DPP)11 from ancestral bacterial DPP7 [0.03%]
二肽基肽酶(DPP)11由祖先细菌型DPP7进化分化而来
Momo Sawase,Kana Shirakura,Yuko Ohara-Nemoto et al.
Momo Sawase et al.
To date, the S46 peptidase family is limited to two members, dipeptidyl-peptidase (DPP)7 and DPP11, which are widely distributed among Gram-negative bacteria and present in both oral and intestinal microbiota. Both peptidases are indispensa...
A molecular perspective on diabetic wound healing: Exploring key signaling pathways [0.03%]
糖尿病伤口愈合的分子机制研究：探索关键信号通路
Anmoy Nandi,N Anirudh Singh,Srijita Chakrabarti
Anmoy Nandi
Diabetic wounds are a serious healthcare concern, affecting approximately 25% of individuals with diabetes globally. Their healing process is often delayed by chronic hyperglycemia, oxidative stress, and persistent inflammation, all of whic...
ETV4 enhances glycolysis to suppress NK-cell cytotoxicity in the immune microenvironment of colon cancer [0.03%]
ETV4通过增强糖酵解抑制结直肠癌免疫微环境中的NK细胞毒性作用
Zixing Zhang,Pengfei Wang,Yingchuan Chen et al.
Zixing Zhang et al.
Immune evasion in colon cancer (CC) is largely driven by the functional suppression of NK cells, yet the specific regulatory role of ETV4 in this process remains poorly defined. We first analyzed ETV4 expression levels in CC through bioinfo...