Bifid triple viable tablets are associated with renal biochemical improvement and qualitative gastrointestinal changes in 5/6-nephrectomized rats: An exploratory microbiome-metabolome study [0.03%]
双歧三联活菌片通过改变肠道菌群改善肾功能并促进肾脏代谢物变化：初步研究
Jiamei Di,Jintang Hu,Feng Zhao et al.
Jiamei Di et al.
Background: Chronic kidney disease (CKD) is accompanied by renal injury, gut-barrier disruption, dysbiosis, inflammation, and disordered iron regulation. We examined whether a clinical multi-strain probiotic produces coor...
Critical role of Asp283 in modulating calcium-dependent autoprocessing of yeast Metacaspase ScMCA-Ia [0.03%]
天冬氨酸283在调节酿酒酵母半胱天冬酶ScMCA-Ia钙依赖性自动加工过程中的关键作用
Mariana Nascimento Romero Trujilho,Laura de Azevedo Maffeis Dalzoto,Taiz Dos Reis Santos et al.
Mariana Nascimento Romero Trujilho et al.
Metacaspases are Ca2+-dependent cysteine proteases essential for programmed cell death. This study elucidates the regulatory mechanisms of Saccharomyces cerevisiae type I metacaspase (ScMCA-IA), focusing on Ca2+-dependent autoprocessing and...
Fosl2/c-Jun dimer induces oxidative stress and endoplasmic reticulum stress by enhancing Lcn2 transcription to promote ischemic cerebral infarction [0.03%]
Fosl2/c-Jun二聚体通过增强Lcn2转录诱导氧化应激和内质网应激以促进缺血性脑梗死
Qi Zhang,Jing Jin,Jianxiu Wang
Qi Zhang
Objective: Ischemic cerebral infarction (ICI) results in high disability and mortality rates. This study aims to validate that the Fosl2/c-Jun dimer promotes ICI via the transcriptional activation of Lcn2. ...
Superparamagnetic iron oxide nanoparticles platforms: Recent trends in cancer treatment [0.03%]
超顺磁性铁氧化物纳米颗粒平台：癌症治疗的最新趋势
Sujan Roy,Rakesh Ghosh,Mita Rani Chanda et al.
Sujan Roy et al.
Disadvantages associated with using antidotes for certain diseases include nonspecificity, undesirable safety profiles, and side effects. For clinical use, additional characteristics such as uneven biodistribution, instability, and rapid de...
Innovative approaches in the therapeutic application of EpCAM aptamer for targeted Cancer treatment: A review [0.03%]
靶向癌症治疗的EpCAM适配体疗法创新应用：综述
Mohammad Hossein Hosseinzadeh,Monireh Askarzadeh,Pedram Ebrahimnejad et al.
Mohammad Hossein Hosseinzadeh et al.
The development of targeted therapies has revolutionized cancer treatment by improving the specificity and efficacy of therapeutic options. Aptamers, short single-stranded nucleic acids, have emerged as a promising class of molecules for ta...
Evolutionary divergence of dipeptidyl-peptidase (DPP)11 from ancestral bacterial DPP7 [0.03%]
二肽基肽酶(DPP)11由祖先细菌型DPP7进化分化而来
Momo Sawase,Kana Shirakura,Yuko Ohara-Nemoto et al.
Momo Sawase et al.
To date, the S46 peptidase family is limited to two members, dipeptidyl-peptidase (DPP)7 and DPP11, which are widely distributed among Gram-negative bacteria and present in both oral and intestinal microbiota. Both peptidases are indispensa...
A molecular perspective on diabetic wound healing: Exploring key signaling pathways [0.03%]
糖尿病伤口愈合的分子机制研究：探索关键信号通路
Anmoy Nandi,N Anirudh Singh,Srijita Chakrabarti
Anmoy Nandi
Diabetic wounds are a serious healthcare concern, affecting approximately 25% of individuals with diabetes globally. Their healing process is often delayed by chronic hyperglycemia, oxidative stress, and persistent inflammation, all of whic...
ETV4 enhances glycolysis to suppress NK-cell cytotoxicity in the immune microenvironment of colon cancer [0.03%]
ETV4通过增强糖酵解抑制结直肠癌免疫微环境中的NK细胞毒性作用
Zixing Zhang,Pengfei Wang,Yingchuan Chen et al.
Zixing Zhang et al.
Immune evasion in colon cancer (CC) is largely driven by the functional suppression of NK cells, yet the specific regulatory role of ETV4 in this process remains poorly defined. We first analyzed ETV4 expression levels in CC through bioinfo...
A defined copper ion window coordinates multicellular responses for predictive vascular implant design [0.03%]
定义性的铜离子窗口协调多细胞反应以设计预测性血管植入物
Dan Zou,Ping Yang,Lang Jiang et al.
Dan Zou et al.
Copper ions have demonstrated significant potential in vascular applications due to their pro-regenerative and antimicrobial properties. Yet, the current research remains fragmented, with a conspicuous absence of a holistic, systems-level u...
Retraction notice to "S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead" [Biochimica et Biophysica Acta (BBA) - General Subjects 1820 (2012) 9-23] [0.03%]
撤销“S-烯丙基半胱氨酸联合克霉唑下调Fas诱导的铅暴露小鼠红细胞中凋亡事件[Biochimica et Biophysica Acta (BBA) - General Subjects 1820 (2012) 9-23]”的通知
Samir Mandal,Sudip Mukherjee,Kaustav Dutta Chowdhury et al.
Samir Mandal et al.