Sphingosine-1-phosphate attenuates seizures and cognitive deficits, associated with reduced hippocampal IL-1β in a PTZ-induced epilepsy model [0.03%]
鞘氨醇-1-磷酸盐可减轻戊四唑诱导的癫痫模型中小发作和认知缺陷，并减少海马中白细胞介素-1β的释放
Kai Luo,Weiwen Zeng,Qing Chen et al.
Kai Luo et al.
Background and aim: Epilepsy is a prevalent neurological disorder frequently accompanied by cognitive impairments and neuronal damage. Neuroinflammation-particularly mediated by interleukin-1β (IL-1β)-plays a critical r...
Autophagy activation by taurine alleviates prion-induced mitochondrial dysfunction and neurotoxicity [0.03%]
牛磺酸介导的自噬激活缓解朊病毒诱导的线粒体功能障碍及神经毒性
Seung-Ok Lee,You-Jin Lee
Seung-Ok Lee
Taurine (2-aminoethanesulfonic acid) is a naturally abundant amino acid known to support mitochondrial stability and neuronal stress resistance; however, its role in prion peptide-induced neurotoxicity has not been established. Here, we inv...
Altered brain glucose metabolism in nicotine use but not in hazardous alcohol consumption or problem gambling of healthy men [0.03%]
健康男性烟酒赌博行为与大脑葡萄糖代谢的关系：横断面[positron emission tomography-computed tomography]研究
Seunghyeon Shin,Keunyoung Kim,Jihyun Kim et al.
Seunghyeon Shin et al.
We aimed to determine whether chronic nicotine use, alcohol consumption, and gambling alters brain glucose metabolism. We retrospectively analyzed data from 131 healthy men who participated in health check-ups at Samsung Changwon Hospital H...
Modulatory effects of GLT-1 enhancer, MC-100093, on neuroinflammatory factors in mesocorticolimbic brain regions of female P rats exposed chronically to ethanol [0.03%]
GLT-1增强剂MC-100093对慢性酒精暴露的雌性P大鼠中脑皮质边缘区神经炎症因子的调节作用
Khokon Kanti Bhowmik,Ahmed Alotaibi,Magid Abou-Gharbia et al.
Khokon Kanti Bhowmik et al.
Chronic ethanol intake increases extracellular glutamate concentrations in important reward-related brain regions, including the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), ultimately resulting in oxidative stress and infla...
Effects of vestibular habituation training on synaptic plasticity in the medial prefrontal cortex of mice with motion sickness [0.03%]
前庭习惯化训练对小鼠运动病脑内中央前额叶皮质突触可塑性的影响
Shu Fang,Ben Wang,Shi-Li Zhang et al.
Shu Fang et al.
Background: Motion sickness (MS) is triggered by vestibular conflict, yet how vestibular habituation training (VHT) engages higher-order cortical circuits remains unclear. ...
Characterization of calcium currents and their contributions to firing behaviour of primary motoneurons in developing zebrafish [0.03%]
发育斑马鱼初级运动神经元钙电流的特征及其对动作电位发放行为的贡献
Stephanie F Gaudreau,Tuan V Bui
Stephanie F Gaudreau
Calcium currents in vertebrate motoneurons undergo developmental changes as motoneurons mature and develop specialized functions. The rapid development of zebrafish presents a unique opportunity to link changes in calcium currents of motone...
The distribution map of α4 and α7 subunits of nAch receptors in the olfactory bulb of male rat neonates born to STZ-induced hyperglycemia model mothers [0.03%]
链脲佐菌素致糖尿病大鼠模型雄性后代海马α4和α7烟碱型乙酰胆碱受体亚单位的分布差异地图研究
Raheleh Baradaran,Nasim Alipour,Fatemeh Rahimi Anbarkeh et al.
Raheleh Baradaran et al.
Background: Alpha4 and alpha7 nicotinic acetylcholine receptors (nAChRs) are critical for neuronal survival and are highly expressed in the rat olfactory bulb (OB). Gestational diabetes mellitus (GDM) affects the central ...
L17E cell-penetrating peptide enhances intranasal delivery of IgG to the cerebrospinal fluid in mice [0.03%]
L17E细胞穿透肽增强小鼠鼻内IgG递送至脑脊液中
Naoya Hashikawa,Taiki Terado,Takuya Noda et al.
Naoya Hashikawa et al.
Antibody-based therapeutics are promising for treating central nervous system (CNS) diseases; however, brain delivery is severely restricted by the blood-brain barrier (BBB). Intranasal administration has gained attention as a noninvasive r...
Repeated exposure to motor imagery enhances focal brain activation during motor imagery practice after stroke [0.03%]
重复进行运动表象以增强卒中后运动表象练习中的局灶性脑激活
Sara M Klick,Cristina Rubino,Justine R Magnuson et al.
Sara M Klick et al.
Stroke results in motor impairments of the upper limbs, linked to altered activation in sensorimotor regions. Motor imagery (MI; the mental rehearsal of movement) activates sensorimotor regions, providing the basis for its effectiveness as ...
Dose-dependent impact of extremely low-frequency electromagnetic field (ELF-EMF) on the neuroplasticity in the hippocampus of adult rats [0.03%]
极低频电磁场（ELF-EMF）对成年大鼠海马神经可塑性剂量依赖性影响
Maciej Klimiuk,Hanna Kletkiewicz,Joanna Wyszkowska et al.
Maciej Klimiuk et al.
Extremely low-frequency electromagnetic field (ELF-EMF) therapy is gaining attention for its potential benefits in treating neurodegenerative conditions. However, the underlying molecular mechanisms responsible for the possible protective e...