Itgb3 expression is developmentally regulated in pyramidal neurons of mouse cortex and hippocampus [0.03%]
Itgb3在小鼠皮层和海马锥体神经元中的表达受发育调控
Hollyn N Cook,Elizabeth C Vinson,Anna R Kalinowski et al.
Hollyn N Cook et al.
Variants in integrin β3 (Itgb3) are associated with autism spectrum disorder and intellectual disability. Itgb3 deletion in mice leads to aberrant development of excitatory pyramidal neurons in the cerebral cortex and hippocampus, as well ...
Indoleamine 2,3-dioxygenase 1 (IDO1) promoted the activation of inflammatory response in the brain tissue of Alzheimer's disease mice by regulating NF-κB pathway [0.03%]
色氨酸2，3-双氧化酶1(IDO1)通过调节NF-κB通路促进阿尔茨海默病小鼠脑组织炎症反应激活
XinQun Xu,QuanLan Wang,Long Wang et al.
XinQun Xu et al.
Objective: To investigate the regulatory mechanism of IDO1 on brain tissue damage in Alzheimer's disease (AD) mice. Methods: APP/PS1 mi...
Perivascular macrophages lack cyclooxygenase-2 induction and do not mediate fever [0.03%]
血管周巨噬细胞缺乏环氧化酶-2的诱导且不介导发热反应
Vladimir Maksimov,Anna Eskilsson
Vladimir Maksimov
Perivascular macrophages, immune cells located in the Virchow-Robin spaces that surround small arterioles, capillaries, and venules in the brain, have been suggested to produce prostaglandins upon immune stimulation and influence centrally ...
ZBP1 deficiency ameliorates the motor dysfunction following brachial plexus root avulsion in mice [0.03%]
ZBP1缺陷通过缓解臂丛根性撕脱后的小鼠运动功能障碍来改善预后
Lei Tang,Yu Peng,Ying Zhang et al.
Lei Tang et al.
Brachial plexus root avulsion (BPRA) is a devastating peripheral nerve injury that results in irreversible forelimb motor dysfunction, largely due to extensive motor neuron (MN) degeneration in the spinal ventral horn accompanied by robust ...
Unilateral damage to the entopeduncular nucleus causes dysfunction in skilled forelimb movement and hinders recovery in rats [0.03%]
内端脑核单侧损伤导致大鼠精巧前肢运动功能障碍及影响恢复效果
Ryo Sakai,Kazuki Kuroda,Takashi Ryoke et al.
Ryo Sakai et al.
The entopeduncular nucleus (EPN) is an output nucleus of the basal ganglia and is suggested to play a critical role in motor control. This study aimed to clarify the impact of EPN damage on skilled motor function and its recovery. Unilatera...
Developmental electrophysiological changes in mouse mesencephalic trigeminal neurons [0.03%]
小鼠中脑三叉神经元的发育电生理学变化
Hiroki Toyoda
Hiroki Toyoda
This study examined the postnatal maturation of electrophysiological properties in mesencephalic trigeminal (MesV) neurons, focusing on firing patterns, intrinsic membrane properties, membrane resonance, and inward‑rectifying currents. Mes...
K+-Cl- cotransporter KCC2 is involved in long-term potentiation at trigeminal excitatory synapses [0.03%]
KCC2共转运蛋白参与三叉神经元兴奋性突触的长期增强作用
Mujiwati,Dong-Ho Youn
Mujiwati
The K+-Cl- cotransporter (KCC)2 is critical for maintaining low intracellular chloride levels and ensuring hyperpolarizing GABAergic inhibition. While KCC2 dysfunction is well established in spinal mechanisms of chronic pain, its role in tr...
The evaluation of HI-6 encapsulated in reconstituted lipid nanoparticles for central delivery and reactivation in soman-poisoned mice [0.03%]
评估HI-6封装的重组脂质纳米颗粒在沙林中毒小鼠中的中枢递送和再激活效果
Tiantian Zhuang,Jiahua Zhao,Xiaosa Yang et al.
Tiantian Zhuang et al.
Nerve agents represent a significant hazard to human health and safety. Prompt reactivation of inhibited cholinesterase is imperative; however, the blood-brain barrier (BBB) impedes the delivery of cholinesterase reactivators to the central...
Liraglutide alleviates postoperative cognitive impairment via NRF2/NLRP3 signal pathway in aged mice [0.03%]
利拉鲁肽通过NRF2/NLRP3信号途径缓解老年小鼠术后认知障碍
Hong Sun,Xue Cheng,Daoyun Lei et al.
Hong Sun et al.
Postoperative cognitive dysfunction (POCD) frequently occurs in elderly surgical patients, yet effective preventive strategies are lacking. This study investigated whether the GLP-1R agonist liraglutide (LIR) could alleviate POCD in aged mi...
Tanshinone IIA, salvianic acid A, salvianolic acid B, and hydroxysafflor yellow A reduce cerebral injury via TGF-β1/Smad3 pathway [0.03%]
丹参酮 ⅡA、丹酚酸A、丹参素和羟基苦参黄素A通过TGF-β1/Smad3信号通路减少脑损伤
Bin Luo,Wenwen Zhang,Yimin Zhang et al.
Bin Luo et al.
Cerebral ischemia-reperfusion injury (CIRI) is a cerebrovascular disorder with high rates of incidence, disability, and death. It has been identified that Salvia miltiorrhiza and safflower have a protective effect in CIRI. However, the syne...