Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry [0.03%]
Lmx1缺乏症对耳蜗核的不同脆弱性：异常模式及其对听觉回路的意义
Igor Iskusnykh,Ebenezer N Yamoah,Victor V Chizhikov et al.
Igor Iskusnykh et al.
Precise regulation of progenitor identity is essential for the formation of functional auditory circuits. Cochlear nuclei arise from two major progenitor populations: Atoh1-expressing progenitors generate excitatory glutamatergic neurons, w...
Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats [0.03%]
大鼠内侧杏仁核nNOS/sGC通路在应激反应调控中的作用
Melissa T Goulart,Cristiane Busnardo,Ivaldo J A Belém-Filho et al.
Melissa T Goulart et al.
The insular cortex (IC) is part of brain networks involved in physiological responses to stressful events. However, the local neurochemical mechanisms involved in the processing of stress responses by IC are still poorly understood. Thus, w...
Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation [0.03%]
Jak1抑制减少大鼠由特定上游细胞因子诱导的急性痛觉异常：对Jak1镇痛机制的启示
Steve McGaraughty,Donna Strasburg,Rich McCarthy et al.
Steve McGaraughty et al.
Clinical data from patients treated with Jak1 inhibitors for diverse autoimmune diseases point to a reduction of pain at the first readouts, hinting at an action on nociceptors prior to its immunomodulatory role. Dorsal root ganglion neuron...
Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study [0.03%]
糖皮质激素致小鼠抑郁样行为的研究-玉米油酸和氢化可的松的比较研究
Carina Ioná de Oliveira Torres,Victor A Duarte Holanda,Matheus Cardoso de Oliveira et al.
Carina Ioná de Oliveira Torres et al.
Chronic administration of glucocorticoids is widely used to model stress-related depression in rodents. However, corticosterone, the primary endogenous glucocorticoid in rodents, is highly lipophilic and typically requires ethanol dissoluti...
Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease [0.03%]
数据驱动的前额叶激活聚类在帕金森病患者优先双重任务步行条件下识别功能表型
Xinyuan Zhang,Weihua Li,Yankun Hu et al.
Xinyuan Zhang et al.
Background: Gait impairment in Parkinson's disease (PD) relates to motor-cognitive interactions, yet the specific neural characteristics patterns of different individuals under various task strategies remain unclear. This...
Antiallodynic effect of a novel sigma-1 receptor antagonist N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide (Dicloperidine): Synthesis and combined bioevaluation [0.03%]
新型σ-1受体拮抗剂N-(1-苯基哌啶-4-基)-2,4-二氯苯甲酰胺(Dicloperidine)的镇痛作用：合成及联合生物评价
Gabriel Navarrete-Vázquez,Diana Karen Morales-Galindo,Rolffy Ortiz-Andrade et al.
Gabriel Navarrete-Vázquez et al.
This study describes the synthesis and combined biological evaluation (in silico, in vitro, and in vivo) of N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide (Dicloperidine), a novel analogue structurally related to compound LMH-2 and halope...
Embedding EEG trajectories in a Möbius-like manifold: An exploratory study [0.03%]
莫比乌斯带状流形中的EEG轨迹：一项探索性研究
Arturo Tozzi
Arturo Tozzi
Time-frequency decompositions and nonlinear dynamical methods analyze electroencephalographic (EEG) signals as time series evolving in Euclidean state spaces. We explore an alternative representation of EEG dynamics in which neural activity...
Brain vascular structures contribute to the outflow of lymphatic vessels in the human [0.03%]
人脑血管结构有助于淋巴管的外流
Damlasu Altınöz,Mazhar Özkan,Ferdane Nilay Mortaş et al.
Damlasu Altınöz et al.
The brain lymphatic system clears metabolic waste from neural tissue, maintains extracellular fluid homeostasis, and supports brain function. Its dysfunction is associated with neurodegenerative disorders and neuroinflammation. Thus, lympha...
Genetic suppressions of CRMP2 phosphorylation ameliorate α-synuclein accumulation in an α-synucleinopathy mouse model [0.03%]
通过基因抑制CRMP2磷酸化缓解α-突触核蛋白病小鼠模型中的α-突触核蛋白聚集现象
Valeria Ayala Guevara,Yoshio Goshima,Toshio Ohshima
Valeria Ayala Guevara
α-synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of phosphorylated α-synuclein, forming the primary component of Lewy bodies. Current treatments can alleviate symptoms, however, there is stil...
CCDC181, a kinocilium-localization protein, is dispensable for hair bundle development and auditory perception [0.03%]
无CCDC181（一种纤毛定位蛋白）的耳蜗感觉毛细胞指状袋结构及听觉功能正常发声母系遗传性耳聋的原因
Chang Liu,Renat Nahornyi,Jinan Li et al.
Chang Liu et al.
Inner ear cochlear hair cells exhibit a highly specialized ciliary architecture that consists of a bundle of stereocilia responsible for mechanotransduction and, during development, a single kinocilium that governs hair bundle polarity. Whi...