Volume-dependent modulation of cerebral cortex Na+,K + -ATPase activity and blood-brain barrier permeability by acute exhaustive exercise in rats [0.03%]
大强度运动对大鼠脑皮质Na+,K+-ATP酶活性及血脑屏障通透性的影响及其与脑容积增加的关系研究
Derick Minuzzi Cardozo,João Victor de Mattos Mautone Pedroso,Eduardo Felipe Alchieri et al.
Derick Minuzzi Cardozo et al.
The Na+,K + -ATPase (NKA) enzyme is crucial for maintaining neuronal excitability, yet its response to acute physical exertion in the central nervous system remains largely unexplored. Here, we report a volume-dependent modulation of NKA ac...
Silencing of pyramidal neurons in the anterior piriform cortex mediates olfactory dysfunction and social novelty deficits in mice [0.03%]
前梨状皮层锥体神经元的沉默介导了小鼠的嗅觉障碍和社交新颖性缺陷
Ling-Zhi Zhang,Zi-Yu Su,Kun Tong et al.
Ling-Zhi Zhang et al.
Background: The olfactory system plays a critical role in modulating social cognition, with the anterior piriform cortex (aPC) serving as a key hub. However, the specific contribution of aPC pyramidal neurons to social re...
NRN1 inhibits neuronal apoptosis and improves motor recovery after spinal cord injury via binding to FZD2 to activate the GSK-3β/Nrf2 pathway [0.03%]
NRN1通过与FZD2结合激活GSK-3β/Nrf2信号通路抑制神经元凋亡并改善脊髓损伤后的运动功能恢复
Yanfei Chen,Jiao Hao,Chenyang Shui
Yanfei Chen
Neuritin 1 (NRN1) is a neurotrophic factor known to protect neurons from damage and cell death; however, its role and mechanism in cervical spinal cord injury (CSCI) remain unclear. In this study, we investigated the function of NRN1 using ...
Xylazine reduces methamphetamine-induced hyperlocomotion in rats through κ-opioid and α2-adrenoceptor mechanisms [0.03%]
丁丙诺啡通过κ阿片受体和α2肾上腺素受体机制降低甲基苯丙胺致小鼠高旷场活动性
Sonita Wiah,Anwar Lami,Scott M Rawls
Sonita Wiah
Xylazine, a veterinary anesthetic, is an adulterant in fentanyl and heroin that worsens opioid-related adverse effects. Two recent evidences - one epidemiological and the other pharmacological - have emerged regarding xylazine. Epidemiologi...
Phosphatase of regenerating liver-1 is associated with inflammatory pain, spinal GluN2B upregulation, and microglial activation [0.03%]
磷再生肝-1与炎症痛、脊髓GluN2B上调和小胶质细胞活化有关
Wenjiao Jin,Longhui Li,Junqi Yang et al.
Wenjiao Jin et al.
Central sensitization in the spinal dorsal horn, characterized by enhanced neuronal excitability and sustained neuroinflammatory responses, is a key mechanism underlying persistent inflammatory pain; however, the upstream molecular regulato...
Sumoylation profiles and mitochondrial dynamics in in vivo and in vitro models of Parkinson's disease [0.03%]
帕金森病体内和体外模型中的SUMO化蛋白质组及线粒体动力学
Letícia Y Queiroz,Stella C Junqueira,Ericks S Soares et al.
Letícia Y Queiroz et al.
Parkinson's disease (PD) is characterized by progressive dopaminergic neuron loss and motor and non-motor impairments. Mitochondrial dysfunction and altered post-translational modifications, including SUMOylation, have emerged as key mechan...
Triple transcranial static magnetic stimulation of a deep cortical area: Findings from the leg motor cortex [0.03%]
三重经颅静态磁场刺激深部皮层区域：来自腿运动皮层的发现
Yusuke Shinozaki,Riku Ishizaka,Miyu Nakamura et al.
Yusuke Shinozaki et al.
Transcranial static magnetic stimulation (tSMS) has been shown to reduce cortical excitability using a small but strong neodymium magnet. Recently, a triple tSMS system combining three magnets has been developed to generate stronger static ...
Intra-locus coeruleus LPS administration induces anxiety-like behavior, thermal hyperalgesia, and striatal lysosomal alterations: Relevance to Parkinson's disease [0.03%]
黑质内注射LPS诱导类似焦虑的行为、热痛觉过敏和纹状体溶酶体的改变：与帕金森病的相关性
Sara El Idrissi,Raquel Durán Ogalla,Alicia Bautista-García et al.
Sara El Idrissi et al.
According to Braak's staging hypothesis, Parkinson's disease (PD) pathology may originate in extranigral regions, including the locus coeruleus (LC). In parallel, PD has been associated with lysosomal dysfunction. Here, we investigated whet...
Diazepam, a positive allosteric modulator of the GABAA receptor induces strain-specific responses in object recognition, ultrasonic vocalizations and monoaminergic profiles in the Wistar Kyoto rat model of endogenous depression [0.03%]
地西泮，一种GABAA受体的正变构调节剂，诱导了WKY抑郁大鼠模型在物体识别、超声波发声和单胺能特征方面的特定应答反应
Akshata T Inavally,Monika Sadananda
Akshata T Inavally
Major depressive disorder (MDD) involves cognitive impairment, altered affective states and dysregulation of neurotransmitter homeostasis. The Wistar Kyoto (WKY) rat is characterized by inherent depressive-like behaviour, anxiety, cognitive...
Silicon-based agent attenuates cerebral ischemia-reperfusion injury in a rat model [0.03%]
硅基药物通过动物实验改善脑卒中后恢复期神经功能缺损及血管内皮细胞损伤的作用研究
Yoshihisa Koyama,Yuki Kobayashi,Hikaru Kobayashi et al.
Yoshihisa Koyama et al.
Cerebral ischemia-reperfusion (IR) injury is a major cause of brain damage following stroke, in which excessive reactive oxygen species play a critical role. Therefore, the development of novel therapeutic agents targeting oxidative stress ...