DAla2-GIP-Glu-PAL exerts neuroprotective effect on diabetic retinopathy by attenuating microglia activation and regulating NF-κB/NLRP3 and Nrf2/HO-1 pathways [0.03%]
DAla₂-GIP-Glu-PAL通过调节NF-κB/NLRP₃和Nrf₂/HO₁通路来减轻小胶质细胞活化，对糖尿病视网膜病变产生神经保护作用
Rui Xie,Li Yuan,Jiahong Cai et al.
Rui Xie et al.
DAla2-GIP-Glu-PAL, a kind of analogue of glucose-dependent insulinotropic polypeptide (GIP), has neuroprotective effects in the central nervous system. Currently, retinal neurodegeneration is regarded as an important feature of diabetic ret...
Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder [0.03%]
Calleja岛神经适应的内啡肽机制及其对酒精使用障碍的影响
Anthony M Cuozzo,Gaetan Lepreux,Daniel J Reis et al.
Anthony M Cuozzo et al.
Dysregulation of the dynorphin (DYN)/kappa-opioid receptor (KOR) system is heavily implicated in symptoms of alcohol use disorder (AUD) including negative affective-like states that can drive maladaptive behavioral regulation. Substantial e...
Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry [0.03%]
Lmx1缺乏症对耳蜗核的不同脆弱性：异常模式及其对听觉回路的意义
Igor Iskusnykh,Ebenezer N Yamoah,Victor V Chizhikov et al.
Igor Iskusnykh et al.
Precise regulation of progenitor identity is essential for the formation of functional auditory circuits. Cochlear nuclei arise from two major progenitor populations: Atoh1-expressing progenitors generate excitatory glutamatergic neurons, w...
Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats [0.03%]
大鼠内侧杏仁核nNOS/sGC通路在应激反应调控中的作用
Melissa T Goulart,Cristiane Busnardo,Ivaldo J A Belém-Filho et al.
Melissa T Goulart et al.
The insular cortex (IC) is part of brain networks involved in physiological responses to stressful events. However, the local neurochemical mechanisms involved in the processing of stress responses by IC are still poorly understood. Thus, w...
Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation [0.03%]
Jak1抑制减少大鼠由特定上游细胞因子诱导的急性痛觉异常：对Jak1镇痛机制的启示
Steve McGaraughty,Donna Strasburg,Rich McCarthy et al.
Steve McGaraughty et al.
Clinical data from patients treated with Jak1 inhibitors for diverse autoimmune diseases point to a reduction of pain at the first readouts, hinting at an action on nociceptors prior to its immunomodulatory role. Dorsal root ganglion neuron...
Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study [0.03%]
糖皮质激素致小鼠抑郁样行为的研究-玉米油酸和氢化可的松的比较研究
Carina Ioná de Oliveira Torres,Victor A Duarte Holanda,Matheus Cardoso de Oliveira et al.
Carina Ioná de Oliveira Torres et al.
Chronic administration of glucocorticoids is widely used to model stress-related depression in rodents. However, corticosterone, the primary endogenous glucocorticoid in rodents, is highly lipophilic and typically requires ethanol dissoluti...
Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease [0.03%]
数据驱动的前额叶激活聚类在帕金森病患者优先双重任务步行条件下识别功能表型
Xinyuan Zhang,Weihua Li,Yankun Hu et al.
Xinyuan Zhang et al.
Background: Gait impairment in Parkinson's disease (PD) relates to motor-cognitive interactions, yet the specific neural characteristics patterns of different individuals under various task strategies remain unclear. This...
Antiallodynic effect of a novel sigma-1 receptor antagonist N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide (Dicloperidine): Synthesis and combined bioevaluation [0.03%]
新型σ-1受体拮抗剂N-(1-苯基哌啶-4-基)-2,4-二氯苯甲酰胺(Dicloperidine)的镇痛作用：合成及联合生物评价
Gabriel Navarrete-Vázquez,Diana Karen Morales-Galindo,Rolffy Ortiz-Andrade et al.
Gabriel Navarrete-Vázquez et al.
This study describes the synthesis and combined biological evaluation (in silico, in vitro, and in vivo) of N-(1-benzylpiperidin-4-yl)-2,4-dichlorobenzamide (Dicloperidine), a novel analogue structurally related to compound LMH-2 and halope...
Embedding EEG trajectories in a Möbius-like manifold: An exploratory study [0.03%]
莫比乌斯带状流形中的EEG轨迹：一项探索性研究
Arturo Tozzi
Arturo Tozzi
Time-frequency decompositions and nonlinear dynamical methods analyze electroencephalographic (EEG) signals as time series evolving in Euclidean state spaces. We explore an alternative representation of EEG dynamics in which neural activity...
Brain vascular structures contribute to the outflow of lymphatic vessels in the human [0.03%]
人脑血管结构有助于淋巴管的外流
Damlasu Altınöz,Mazhar Özkan,Ferdane Nilay Mortaş et al.
Damlasu Altınöz et al.
The brain lymphatic system clears metabolic waste from neural tissue, maintains extracellular fluid homeostasis, and supports brain function. Its dysfunction is associated with neurodegenerative disorders and neuroinflammation. Thus, lympha...