Cecilia I Attorresi,Javier A Ramírez,Bernhard Westermann
Cecilia I Attorresi
Formaldehyde emerges as a cornerstone in multicomponent reactions, mainly prized for its robust reactivity. Yet, alongside these beneficial traits, this highly reactive C1-building block raises concerns, primarily regarding its toxicity. On...
Long K San,Sebastian Balser,Brian J Reeves et al.
Long K San et al.
A new deep-blue emitting and highly fluorescent anthracene (ANTH) derivative containing perfluorobenzyl (BnF) groups, 9,10-ANTH(BnF)2, was synthesized in a single step reaction of ANTH or ANTH(Br)2 with BnFI, using either a high-temperature...
Binding of tryptophan and tryptophan-containing peptides in water by a glucose naphtho crown ether [0.03%]
葡萄糖萘冠醚在水中对色氨酸和含色氨酸肽的结合
Gianpaolo Gallo,Bartosz Lewandowski
Gianpaolo Gallo
Tryptophan fulfills a plethora of important functions in nature both in its free form and as a component of peptides and proteins. Selective binding of tryptophan is therefore important for diagnostic and medicinal applications. Recently, w...
Thomas Schachtsiek,Jona Voss,Maren Hamsen et al.
Thomas Schachtsiek et al.
Drug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge. Cr...
Synthesis of electrophile-tethered preQ1 analogs for covalent attachment to preQ1 RNA [0.03%]
用于共价连接到preQ1 RNA的亲电基团固定的preQ1类似物的合成
Laurin Flemmich,Ronald Micura
Laurin Flemmich
The preQ1 cIass-I riboswitch aptamer can utilize 7-aminomethyl-7-deazaguanine (preQ1) ligands that are equipped with an electrophilic handle for the covalent attachment of the ligand to the RNA. The simplicity of the underlying design of ir...
Unprecedented visible light-initiated topochemical [2 + 2] cycloaddition in a functionalized bimane dye [0.03%]
功能化二苯并马来酰亚肼染料中前所未有的可见光引发的拓扑[2+2]环加成反应
Metodej Dvoracek,Brendan Twamley,Mathias O Senge et al.
Metodej Dvoracek et al.
Bimanes, a class of molecules based on the 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione scaffold, were first introduced by E. M. Kosower in 1978. In this study, we report the topochemical cycloaddition of diethyl 2,6-dichloro-1,7-dioxo-1H,7H-pyr...
Synthesis of N-acetyl diazocine derivatives via cross-coupling reaction [0.03%]
通过交叉偶联反应合成N-乙酰基叠氮卓衍生物
Thomas Brandt,Pascal Lentes,Jeremy Rudtke et al.
Thomas Brandt et al.
Diazocines are photoswitches derived from azobenzenes by bridging the two phenyl rings in ortho position with a CH2CH2 group forming an eight membered (diazocine) ring. Diazocine is superior to most azobenzenes in almost all photophysical p...
Biyu An,Xueyang Wang,Ao Jiao et al.
Biyu An et al.
Tribolium castaneum Herbst is a destructive stored product pest. The aggregation pheromone of this pest was prepared via a new and effective strategy. The key steps include the ring-opening reaction of chiral 2-methyloxirane, the stereospec...
Organocatalytic kinetic resolution of 1,5-dicarbonyl compounds through a retro-Michael reaction [0.03%]
通过逆迈克尔加成反应实现1,5-二羰基化合物的有机催化动力学拆分
James Guevara-Pulido,Fernando González-Pérez,José M Andrés et al.
James Guevara-Pulido et al.
The pharmaceutical chemical industry has long used kinetic resolution to obtain high-value compounds. Organocatalysis has recently been added to this strategy, allowing for the resolution of racemic mixtures with low catalyst loadings and m...
Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates [0.03%]
4-烷基亚甲基-5-氨基吡唑与三氟甲基丙烯酸甲酯的双烯功能化反应
Judit Hostalet-Romero,Laura Carceller-Ferrer,Gonzalo Blay et al.
Judit Hostalet-Romero et al.
A valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group and a pyrazole ring is presented. The correspondin...