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Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates

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A valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group and a pyrazole ring is presented. The corresponding trifluoromethyl al... ...