Synthesis of electrophile-tethered preQ1 analogs for covalent attachment to preQ1 RNA
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The preQ1 cIass-I riboswitch aptamer can utilize 7-aminomethyl-7-deazaguanine (preQ1) ligands that are equipped with an electrophilic handle for the covalent attachment of the ligand to the RNA. The simplicity of the underlying design of irreversibly bound lig... ...
