Chiral cyclopropenimine-catalyzed enantioselective Michael reactions of phenol and benzofuran-derived α,β-unsaturated pyrazolamides with benzophenone-imine of glycine esters [0.03%]
联苯甲酰亚胺和α,β-不饱和吡唑酰胺的迈克尔加成反应研究取得进展
Ya Bai,Xue-Ying Wang,Si-Kai Zhu et al.
Ya Bai et al.
The enantioselective Michael reactions of benzophenone-imine of glycine esters with phenol- and benzofuran-derived α,β-unsaturated pyrazolamides have been realized by using a chiral cyclopropenimine (Lambert catalyst, CSB-1) as an organoc...
A practical CO2-mediated synthesis of 5,6-carboxylated silicon-rhodamines for targeted probe development [0.03%]
一种实用的二氧化碳介导合成5,6-羧基硅茋类化合物的方法用于靶向探针开发
Dongjie Hou,Shaowei Wu,Ning Xu et al.
Dongjie Hou et al.
Silicon-rhodamine (SiR) dyes are among the most important fluorophores for super-resolution imaging owing to their far-red emission, high photostability, and tunable lactone-zwitterion equilibrium. However, their broader application in targ...
Palladium-catalyzed benzocyclization reactions of quinoline-2-carboxamides via sequential C-H/N-H functionalization [0.03%]
通过连续的C-H/N-H活化反应合成苯并杂环化合物
Shoichi Sugita,Kentaro Okano,Atsunori Mori
Shoichi Sugita
A novel benzocyclization protocol has been developed for the synthesis of quinoline-fused lactams by palladium-catalyzed sequential C-H/N-H functionalization of quinoline-2-carboxamides and 1,2-dihaloarenes. The reaction proceeds at the C-H...
Cascade transformation of 2-(diazoacetyl)-2 H-azirines to 2-aroyl-3-hydroxy-1 H-pyrroles via condensation with aromatic aldehydes [0.03%]
2-(重氮乙酰基)-2H-恶嗪经芳香醛缩合 cascade 转化为2-芳酰基-3-羟基-1H-吡咯类化合物
Timur O Zanakhov,Ekaterina E Galenko,Mikhail S Novikov et al.
Timur O Zanakhov et al.
The Cs2CO3-induced condensation of 2-(diazoacetyl)-2H-azirines with aromatic aldehydes does not result in the formation of an azirinyl-substituted β-hydroxy-α-diazocarbonyl compound, but is accompanied by a tandem intramolecular cyclizati...
Recent advances in copper-catalyzed direct hydroamination of alkenes with (hetero)aromatic amines [0.03%]
近年来铜催化不饱和键直接与芳胺烃氨化反应的研究进展
Hyejeong Lee,Yunmi Lee
Hyejeong Lee
Nitrogen-containing aromatic amines and aza-heterocycles are ubiquitous motifs in pharmaceuticals and functional materials, making efficient C-N bond formation a fundamental transformation in synthetic chemistry. The direct hydroamination o...
Site-specific labelling of native peptides and proteins: chemical and enzymatic strategies [0.03%]
肽和蛋白质的原位标记：化学及酶促策略
Antonio Angelastro,Jonathan Bargh,Subhajit Guria et al.
Antonio Angelastro et al.
Site-specific modifications of native-sequence proteins are technologies that underpin progresses in chemical biology, diagnostics and next-generation biotherapeutics. However, the pursuit of site-specificity has often come at the expense o...
Diastereodivergent electrophilic trapping of α-boryl lithium derivatives [0.03%]
α-硼基锂衍生物的对映发散式亲电捕获反应
Tereza Pavlíčková,Noam Orbach,Ilan Marek
Tereza Pavlíčková
α-Boryl carbanions are valuable organoboron intermediates, but controlling their stereoselective reactions remains challenging. Here, we examine the diastereoselective generation and trapping of α-boryl lithium species formed by ring open...
Unsymmetrical sulfoxides with sterically hindered catechol fragment: synthesis, structure, electrochemical properties, and antiradical activity [0.03%]
受空间位阻限制的儿茶酚亚砜片段的不对称硫氧化合物：合成，结构，电化学性质和抗自由基活性
Daria A Burmistrova,Vasiliy A Fokin,Oleg P Demidov et al.
Daria A Burmistrova et al.
New unsymmetrical sulfoxides containing a redox-active sterically hindered catechol fragment and a nonpolar hydrocarbon substituent at the sulfoxide group were synthesized via the oxidation of the corresponding catechol thioethers with hydr...
Manfred Bochmann
Manfred Bochmann
Gold catalysis has developed into an increasingly important method in organic synthesis. Especially the potential of gold(I,III) redox systems and gold(III) complexes has more recently become a focus of interest. Although often underestimat...
Darya S Cheshkina,Christina S Becker,Alina A Sonina et al.
Darya S Cheshkina et al.
Diazafluorenylidenes are potential antitumor agents, ligands, and functional materials. However, there are currently only limited methods for their synthesis, which are complicated and typically based on modifications of 4,5-diazafluorenone...