Synthetic approach to borrelidin fragments: focus on key intermediates [0.03%]
泛素连接酶ROC1的激活与人类肿瘤之间的关系研究
Yudhi Dwi Kurniawan,Zetryana Puteri Tachrim,Teni Ernawati et al.
Yudhi Dwi Kurniawan et al.
Borrelidin, a naturally occurring antibiotic, has attracted considerable interest due to its diverse biological activities and complex molecular architecture. Although extensive research has explored its pharmacological properties and vario...
Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer [0.03%]
近期基于酰胺自由基介导的光催化直接分子间氢原子转移研究进展
Hao-Sen Wang,Lin Li,Xin Chen et al.
Hao-Sen Wang et al.
In recent years, amidyl radicals have emerged as highly efficient and versatile reagents for hydrogen atom transfer (HAT) in photocatalytic reactions. These radicals display exceptional selectivity and efficiency in abstracting hydrogen ato...
Enhancing chemical synthesis planning: automated quantum mechanics-based regioselectivity prediction for C-H activation with directing groups [0.03%]
通过导向基团增强化学合成规划：基于量子力学的C-H活化区域选择性预测的自动化
Julius Seumer,Nicolai Ree,Jan H Jensen
Julius Seumer
The mild and selective functionalization of carbon-hydrogen (C-H) bonds remains a pivotal challenge in organic synthesis, crucial for developing complex molecular architectures in pharmaceuticals, polymers, and agrochemicals. Despite advanc...
Oxetanes: formation, reactivity and total syntheses of natural products [0.03%]
氧杂环乙烷：生成、反应性及天然产物的全合成
Peter Gabko,Martin Kalník,Maroš Bella
Peter Gabko
Oxetanes are 4-membered cyclic monoethers which have found important applications in medicinal chemistry as polar and metabolically stable isosteric replacements for gem-dimethyl and carbonyl groups. This work reviews possible synthetic str...
Recent advances in oxidative radical difunctionalization of N-arylacrylamides enabled by carbon radical reagents [0.03%]
碳自由基试剂促进的N-芳基丙烯酰胺氧化性自由基双官能团化反应的新进展
Jiangfei Chen,Yi-Lin Qu,Ming Yuan et al.
Jiangfei Chen et al.
The field of radical-mediated functionalization of N-arylacrylamides has experienced considerable advancements in recent years, particularly in the domain of oxidative radical difunctionalization reactions employing carbon radical reagents....
Optimized synthesis of aroyl- S,N-ketene acetals by omission of solubilizing alcohol cosolvents [0.03%]
通过省略助溶性醇共溶剂优化芳基-S,N-酮烯丙酯的合成
Julius Krenzer,Thomas J J Müller
Julius Krenzer
Aroyl-S,N-ketene acetals are obtained by condensation of aroyl chlorides and 2-methyl-N-benzylbenzothiazolium salts in 1,4-dioxane at room temperature in short reaction time in 20-99% yield. This protocol represents a considerable improveme...
Synthesis of β-ketophosphonates through aerobic copper(II)-mediated phosphorylation of enol acetates [0.03%]
铜(II)介导的分子氧参与下烯醇醋酸酯磷化的β-酮亚磷酸酯合成反应研究
Alexander S Budnikov,Igor B Krylov,Fedor K Monin et al.
Alexander S Budnikov et al.
Aerobic copper(II)-mediated phosphorylation of enol acetates with H-phosphonates leading to the formation of β-ketophosphonates was discovered. The proposed method is applicable to a wide range of H-phosphonates or phosphine oxides as PH-r...
A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones [0.03%]
由多组分反应引发的并四苯并咪唑类化合物的合成
Ashutosh Nath,John Mark Awad,Wei Zhang
Ashutosh Nath
A new synthetic route initiated with Groebke-Blackburn-Bienaymé (GBB) followed by N-acylation, intramolecular Diels-Alder (IMDA), and dehydrative re-aromatization reactions for the synthesis of imidazopyridine-fused isoquinolinones is deve...
Susana Santos Braga
Susana Santos Braga
Cyclodextrins (CDs) are known for their ability to form supramolecular interactions with a wide range of guest molecules. In this review, focus is given on the inclusion of complex aurate ions such as tetrabromoaurate, dicyanoaurate and a f...
Erich Gebel,Cornelia Göcke,Carolin Gruner et al.
Erich Gebel et al.
Pipecolic acid is known as a non-proteinogenic amino acid with a secondary amine. It contains a six-membered ring and is, like its five-membered correlate, known for its secondary structure inducing properties, which are particularly useful...