Optimized synthesis of aroyl- S,N-ketene acetals by omission of solubilizing alcohol cosolvents
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Aroyl-S,N-ketene acetals are obtained by condensation of aroyl chlorides and 2-methyl-N-benzylbenzothiazolium salts in 1,4-dioxane at room temperature in short reaction time in 20-99% yield. This protocol represents a considerable improvement over the standard... ...