Extracellular vesicles enriched with miR-486 from Tetramethylpyrazine-preconditioned bone marrow mesenchymal stem cells promote microglia/macrophage M2 polarization and enhance neurogenesis in rats with ischemic stroke [0.03%]
四氢吡咯预处理骨髓间充质干细胞来源的富含miR-486的细胞外囊泡促进缺血性卒大鼠小胶质细胞/巨噬M2极化及神经发生
Shihui Mao,Ting Lan,Yimei Sun et al.
Shihui Mao et al.
Background: Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) show therapeutic promise for ischemic stroke (IS). Preconditioning MSCs with drugs can modulate the cargo composition and function of...
Co-treatments of vitamin D and mesenchymal stem cells effectively alleviate the diabetic kidney disease through attenuating the SIRT1-mediated pathways [0.03%]
维生素D和间充质干细胞联合治疗通过抑制SIRT1介导的通路有效缓解糖尿病肾病
Xinfeng Zhao,Sirui He,Xin Luo et al.
Xinfeng Zhao et al.
Background: Diabetic kidney disease (DKD) is still as a common chronic micro-vascular complication of type 1 diabetic (T1DM). Although many studies had verified the therapeutic potential of mesenchymal stem cells (MSCs) o...
β-Sitosterol preconditioning enhances the resistance of BMSCs and chondrocyte to oxidative stress and promotes cartilage repair in osteoarthritis [0.03%]
β-谷固醇预处理可增强骨髓间充质干细胞和软骨细胞的抗氧化能力并促进骨关节炎软骨修复
Chengyin Liu,Xiaoman Wang,Yanyan Zhang et al.
Chengyin Liu et al.
Background: Osteoarthritis (OA) is a joint disorder that severely affects patients' mobility, overall health, and ability to perform daily activities. Despite advancements in therapeutic strategies, stem cell-based therap...
Extracellular vesicles derived from clonal mesenchymal stromal cells preconditioned by indirect hypoxia modulate immune responses in diabetic mice more effectively than directly preconditioned vesicles [0.03%]
间接低氧预处理克隆间充质基质细胞来源的外泌体比直接低氧预处理更有效地调节糖尿病小鼠的免疫反应
Mehdi Soleymani-Goloujeh,Mahnaz Babaahmadi,Faezeh Shekari et al.
Mehdi Soleymani-Goloujeh et al.
Background: Mesenchymal stem/stromal cells (MSCs) or MSC-derived extracellular vesicles (MSC-EVs) are considered potential modulators of the immune system in type 1 diabetes (T1D) therapy. On the other hand, preconditioni...
Advancements in mesenchymal stromal cells for treating connective tissue disease-associated interstitial lung disease: from basic research to clinical application [0.03%]
间充质基质细胞治疗结缔组织病相关间质性肺疾病的进展：从基础研究到临床应用
Jiao Yuan,Yan-Li Yang,Ya-Lin Zhao et al.
Jiao Yuan et al.
Interstitial lung disease (ILD) is a common complication associated with connective tissue disease (CTD). It is characterized by a progressive decline in lung function, significantly affecting prognosis and potentially leading to respirator...
Conditional immortalization of mesenchymal stem cells and their extracellular vesicles therapy for interstitial cystitis/bladder pain syndrome [0.03%]
条件性永生化间充质干细胞及其细胞外囊泡治疗间质性膀胱炎/膀胱疼痛综合征
Guolong Liao,Canling Long,Rui Guo et al.
Guolong Liao et al.
Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by debilitating pelvic pain. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are recognized as pivotal m...
Comparison of culture media supplements identifies serum components in self-reported serum-free preparations [0.03%]
比较培养基补充物发现自报的无血清培养基制剂中的血清成分
Willem Delabie,Vicky Vandewalle,Sabrina Seghers et al.
Willem Delabie et al.
Background: Cell culture media are essential for cell expansion and many cells still depend on blood-derived supplements for optimal growth. From a regulatory perspective, these materials are ideally xeno-free, serum-free...
Leptin receptor signaling mediates the distinct tendon-bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears [0.03%]
瘦素受体信号介导了肩袖撕裂和骨质疏松共病肩袖撕裂特有的肌腱-骨界面重建作用机制
Dongxu Zhu,Xinrui Zhu,Yingze Zhang et al.
Dongxu Zhu et al.
Background: The intact tendon-bone interface (TBI) consists of four histological layers-tendon, fibrocartilage, calcified fibrocartilage, and bone-that gradually merge into each other, making complete structural restorati...
Evaluation of the efficacy of FDG-PET/CT in assessing the effects of BMMSC treatment in aged rhesus monkeys [0.03%]
评价FDG-PET/CT在评估骨髓间充质干细胞治疗老年食蟹猴效果中的作用
Yaohui Zhang,Jie Li,Longbao Lü et al.
Yaohui Zhang et al.
To evaluate the therapeutic efficacy of BMMSCs in aged rhesus monkeys, histological texture features were analyzed using 18F-FDG-PET/CT imaging. The study involved three groups: five juvenile rhesus monkeys (mean age 2 years, weight 4.6 ± ...
Inflammatory cytokine-primed MSC-derived extracellular vesicles ameliorate acute lung injury via enhanced immunomodulation and alveolar repair [0.03%]
炎症细胞因子预激活的间充质干细胞来源的外泌体通过增强免疫调节和肺泡修复改善急性肺损伤
Jongwon Jeong,Jun-Kook Park,Jiwon Shin et al.
Jongwon Jeong et al.
Background: Acute lung injury (ALI) is characterized by excessive inflammation and alveolar damage, arising from pathogens or systemic insults such as sepsis, and can progress to severe acute respiratory distress syndrome...