SRP/dGATAb modulates the ecdysone response bidirectionally via locus-specific regulatory landscape [0.03%]
SRP/dGATAb通过基因位点特异性调控景观双向调节保幼激素应答
Aleksandra A Evdokimova,Anna A Tarakanova,Maksim Erokhin et al.
Aleksandra A Evdokimova et al.
Background: Steroid hormones drive the transcription of developmental genes by activating distinct sets of enhancers across tissues and developmental contexts, but the mechanisms that target specific enhancers remain inco...
Dynamic architecture of mammalian paternal chromatin: histone-to-protamine exchange and post-fertilization reprogramming [0.03%]
哺乳动物雄配子组蛋白到精素的交换及受精后的重编程动态机制
Amir Masoud Firouzabadi,Farzaneh Fesahat,Seyed Morteza Seifati
Amir Masoud Firouzabadi
Chromatin remodeling in male germ cells and after fertilization plays a pivotal role in genetic transmission and early embryonic development. During spermatogenesis, histone-based chromatin undergoes progressive reorganization: canonical hi...
Genome-wide demethylation and targeted remethylation during metamorphosis in the jewel wasp Nasonia vitripennis [0.03%]
用于珠宝寄生蜂Nasonia vitripennis变态过程的全基因组去甲基化及靶向再甲基化的研究
C L Thomas,E B Mallon
C L Thomas
DNA methylation plays a critical regulatory role during insect development, yet the underlying mechanisms remain poorly understood. Here, we provide a comprehensive profile of DNA methylation dynamics across the developmental stages of the ...
Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5 [0.03%]
染色质的局部环境决定了组蛋白去甲基化酶KDM5的转录结果
Matanel Yheskel,Melissa A Castiglione,Julie Secombe
Matanel Yheskel
Background: Lysine demethylase 5 (KDM5) family proteins are transcriptional regulators best known for demethylating the promoter-proximal histone mark H3K4me3. KDM5-mediated regulation of gene expression is crucial in the...
Developmentally dynamic chromatin state at loci regulating organ crosstalk by remote sensing and signaling [0.03%]
远程感应和信号传导调节器官串扰的调控区域动态染色状态研究
Aditya Parmar,Sanjay K Nigam,Kun Cai et al.
Aditya Parmar et al.
Background: Interorgan communication, metabolite regulation and drug handling require fine-tuned small molecule transport across membranes. The Remote Sensing and Signaling (RSS) theory, which has found applicability in c...
ZAD mediates chromatin binding and insulator activity of Drosophila Pita and can be replaced with the human ZFP276 ZAD-like domain [0.03%]
ZAD介导Drosophila Pita的染色质结合与绝缘子活性，并且可以被人类ZFP276 ZAD样结构域所取代
Yulia Vasileva,Olga Kyrchanova,Natalia Klimenko et al.
Yulia Vasileva et al.
Background: The zinc finger-associated domain (ZAD), found in numerous Drosophila architectural proteins, such as Pita, enables homodimerization. Despite its prevalence in insects, only one human protein, ZFP276, possesse...
Loss of TET2 activity limits the ability of vitamin C to activate DNA demethylation in human HAP1 cells [0.03%]
TET2失活限制了维生素C在人类HAP1细胞中激活DNA去甲基化的能力
Maciej Gawronski,Marta Starczak,Aleksandra Wasilow et al.
Maciej Gawronski et al.
Background: The TET family of proteins-TET1, TET2, and TET3-are α-KG and Fe2+ dependent dioxygenases that play crucial roles in active DNA demethylation and the deposition of epigenetic marks such as 5-hydroxymethylcytos...
Mechanistic basis for the opposing effects of H2A and H2B ubiquitination on nucleosome stability and dynamics [0.03%]
组蛋白H2A和H2B泛素化对核小体稳定性和动态性相反影响的作用机制
Lokesh Baweja,Jeff Wereszczynski
Lokesh Baweja
Background: Nucleosome ubiquitination at lysine 119 of histone H2A (H2AK119ub) and lysine 120 of histone H2B (H2BK120ub) are prominent post-translational modifications with opposing roles in chromatin regulation. Although...
Bmi1 controls auditory sensory epithelial cell proliferation through genome-wide H3K27me3 modifications [0.03%]
Bmi1通过全基因组H3K27me3修饰控制听觉感觉上皮细胞增殖
Xiaoling Lu,Yunzhong Zhang,Ruofei Dai et al.
Xiaoling Lu et al.
Background: Bmi1, a key component of the Polycomb repressive complex 1, plays a critical role in regulating gene expression by modulating chromatin structure. Its depletion is known to cause hair cell loss in the neonatal...
5-Hydroxymethylcytosine: a key epigenetic mark in cancer and chemotherapy response [0.03%]
5-羟甲基胞嘧啶：癌症及化疗反应中的关键表观遗传标志
Suhas S Kharat,Shyam K Sharan
Suhas S Kharat
5-hydroxymethylcytosine (5hmC), an epigenetic modification derived from the oxidation of 5-methylcytosine (5mC) by the ten-eleven translocation (TET) family of dioxygenases, plays a pivotal role in the regulation of gene expression, cellula...