An RNAi-based platform for spatiotemporal control of histone gene expression during animal development [0.03%]
基于RNA干扰的平台技术实现动物发育过程中组蛋白基因时空表达调控
Oscar M Arroyo,Mary P Leatham-Jensen,Daniel J McKay
Oscar M Arroyo
Background: Mutational analysis of histones provides an important means of studying the function of histone post-translational modifications (PTMs) in epigenetic gene regulation. However, several technical challenges have...
Image-based epigenetic profiling with deep learning and high-speed super-resolution microscopy [0.03%]
基于深度学习和高速超分辨显微镜的图像表观遗传分析
Yicheng Wang,Nur Syatila Ab Ghani,Munmee Dutta et al.
Yicheng Wang et al.
High-resolution map of chromatin accessibility - insights into the focused binding of a large number of transcription factors [0.03%]
染色质开放区域高分辨率图谱与大量转录因子低占用率的关系初探
Iris Zhu,David Landsman
Iris Zhu
Background: Emerging evidence has shown the common occupancy of dozens to hundreds of transcription factors (TFs) on cis-regulatory elements (CREs), yet the underlying details are largely unknown. ...
SETDB1/ATF7IP regulate the precise genome engineering of HUSH-regulated genes [0.03%]
SETDB1/ATF7IP调控HUSH调节基因的精准基因组编辑
Brian L Ruis,Henry Ward,Chad L Myers et al.
Brian L Ruis et al.
Background: The use of programmable nucleases has transformed genome editing and functional genomics. Clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) was developed such that targete...
So Youn Shin,Momtahina Tahmida,Nadejda Beliakova-Bethell et al.
So Youn Shin et al.
Major pharmacologic advances the past few decades have transformed infection with Human Immunodeficiency Virus (HIV) from a fatal disease into a chronic, manageable condition for people with access to antiretroviral therapy (ART). However, ...
Effects of topological domain disruption on transcriptional regulation are chromatin context dependent [0.03%]
拓扑关联结构域破坏的转录调控效应依赖染色质背景
Ángel Josué Cerecedo-Castillo,Diana Itzé Mojica-Santamaría,Hober Nelson Núñez-Martínez et al.
Ángel Josué Cerecedo-Castillo et al.
Background: Three-dimensional genome organization helps coordinate enhancer-promoter communication while insulating loci from inappropriate regulatory contacts. CTCF and cohesin contribute to this organization by forming ...
Daphnia magna diapause-interrupted embryogenesis has changes in histone modifications at H3K9 [0.03%]
大型水蚤休眠中断胚胎发育过程中H3K9组蛋白修饰变化
Luxi Chen,Rocío Gómez,Frauke Brenne et al.
Luxi Chen et al.
As a key component of freshwater ecosystem, Daphnia survives environmental challenges by entering a state of developmental arrest known as diapause. Diapause is not simply a sudden halt in growth and development, but a genetically regulated...
DNA variants affecting chromatin structure are key to the genetic architecture of obsessive compulsive disorder [0.03%]
影响染色质结构的DNA变异是强迫症遗传结构的关键因素
Velda X Han,Shrujna Patel,Shekeeb S Mohammad et al.
Velda X Han et al.
Background: Obsessive Compulsive Disorder (OCD) affects 2 to 3% of the population and is marked by intrusive thoughts and repetitive behaviours. OCD is increasingly recognized as a polygenic disorder involving gene-enviro...
Interaction of serotonin transporter and TGFB1 facilitates histone serotonylation-mediated synaptic plasticity following environmental enrichment in stressed mouse Mus booduga [0.03%]
五羟色胺转运蛋白与TGFB1的互作通过环境富集促进应激小花鼠纹状体突触可塑性及相关组蛋白色氨酰化的修饰
Swamynathan Sowndharya,Koilmani Emmanuvel Rajan
Swamynathan Sowndharya
Physicochemical features of intrinsically disordered regions predict DNA-demethylation-promoting activity of transcription factors [0.03%]
转录因子的内在无序区域的理化特性可预测其促DNA去甲基化活性
Xian-Yang Qin,Yuta Sakamoto,Feifei Wei et al.
Xian-Yang Qin et al.
Background: Transcription factor (TF)-dependent DNA demethylation is associated with generation of specific DNA methylation profiles in normal cellular development and disease, although only a small fraction of TFs are kn...