Rickettsia parkeri subverts nicotinamide adenine dinucleotide (NAD+) metabolic pathway for its survival in endothelial cells [0.03%]
立克次体Rickettsia parkeri通过劫持烟酰胺腺嘌呤二核苷酸（NAD+）代谢途径在内皮细胞中存活下来
Lichao Liu,Jeremy W Turck,Shahid Karim et al.
Lichao Liu et al.
Rickettsia parkeri rickettsiosis is an emerging tick-borne disease in humans. The bacterium R. parkeri is primarily transmitted to humans by the Gulf Coast tick, Amblyomma maculatum. Upon transmission to the host, R. parkeri infects and mul...
Automodification of N-terminal serine residues facilitates PARP2 release from DNA [0.03%]
N端丝氨酸残基的自动修饰促进PARP2从DNA上释放
Saurabh Singh Dhakar,Albert Galera-Prat,Jin Cai et al.
Saurabh Singh Dhakar et al.
ADP-ribosyltransferases PARP1 and PARP2 are involved in DNA repair mechanisms and play a major role in detecting DNA damage. PARP1/2 enzymes transfer the ADP-ribosyl moiety from NAD+ to DNA damage response proteins, histones and to itself, ...
Regulation of PHOX2B gene expression by the long non-coding natural antisense RNA PHOX2B-AS1 [0.03%]
长非编码天然反义RNA PHOX2B-AS1调节PHOX2B基因表达
Simona Di Lascio,Ana Lucia Cuadros Gamboa,Martina Bertocchi et al.
Simona Di Lascio et al.
Paired mesoderm homeobox protein 2B (PHOX2B) is a transcription factor essential for autonomic nervous system development. Heterozygous mutations in the PHOX2B gene are associated with neurodevelopmental disorders, including congenital cent...
Karen H Vousden,Hajrah Khawaja
Karen H Vousden
Karen Vousden is an internationally renowned scientist who has made seminal contributions to p53 biology and cancer metabolism. She is currently a group leader at the Francis Crick Institute in London, where she heads the 'Tumour and host m...
Characterisation of a phylogenetically distinct PL25 family ulvan lyase from a seaweed biomass enriched metagenome [0.03%]
从富含海藻生物质的元基因组中表征一种系统进化上独立的PL25家族硫酸化杂多糖裂解酶ulfan酶
Andrius Jasilionis,Pavithra Sivakumar,Justyna M Dobruchowska et al.
Andrius Jasilionis et al.
Ulvan is a polysaccharide most abundant in green macroalgae biomass. Investigation of ulvan confirmed the potential of the polysaccharide for food, pharmaceutical and chemistry applications, emphasising the beneficial properties of ulvan ol...
Intrinsic specificity of a 'core' TIP60 acetyltransferase complex in Drosophila [0.03%]
果蝇中“核心”TIP60乙酰转移酶复合体的内在特异性
Silke Krause,Marco Borsò,Marisa Müller et al.
Silke Krause et al.
The acetylation of histones is a central component of reversible chromatin modification that governs genome regulation. Understanding the complex histone acetylation network requires knowledge about the contributions of individual acetyltra...
Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide-dependent enzyme in the archaeal mevalonate pathway [0.03%]
解析古菌甲羟戊酸途径中牻牛儿基单核苷酸依赖型无水我醇酸磷酸酯脱羧酶的性质和反应机制
Rino Ishikawa,Natsumi Matsushima,Soma Ishimine et al.
Rino Ishikawa et al.
In the archaeal mevalonate pathway, the prototype of all existing mevalonate pathways, a unique intermediate, trans-anhydromevalonate phosphate, is decarboxylated to form isopentenyl phosphate. The key reaction is catalyzed by a 3-octapreny...
So Yeon Lee,Hyun Ho Park
So Yeon Lee
CRISPR-Cas systems provide adaptive immunity to bacteria, although bacteriophages counter these defenses with anti-CRISPR (Acr) proteins. Acr expression is frequently regulated by anti-CRISPR associated (Aca) proteins, which repress transcr...
Coenzyme A mitigates cystine-deprivation-induced ferroptosis by suppressing the iron-starvation response [0.03%]
辅酶A通过抑制缺铁反应缓解胱氨酸缺乏诱导的铁死亡
Mingjun Tan,Yunzhan Li,Lei Sang et al.
Mingjun Tan et al.
The labile iron pool in the cell is required for ferroptosis, a form of regulated cell death resulting from excessive lipid peroxidation and membrane damage. Glutathione (GSH) is critical for lipid-peroxide scavenging, and cysteine is the r...
A perilysosomal feedforward mechanism regulates starvation-induced calcium signaling [0.03%]
溶酶体危险信号机制调节饥饿诱导的钙离子信号转导
Jennifer Giles,Abbie Sesker,Marcos Gonzalez et al.
Jennifer Giles et al.
Nutrient depletion triggers a starvation-induced calcium (Ca2+) signal (SICS) that promotes Ca2+-dependent responses. However, the components and regulations of SICS are unclear. Here, we explored SICS components and their regulation by the...