PEMT-mediated phospholipid imbalance promotes age-associated metabolic dysfunction-associated steatotic liver disease progression [0.03%]
PEMT介导的磷脂失衡促进衰老相关的代谢功能异常性脂肪肝病进展
Xilong Gao,Jiahui Gong,Yichao Hou et al.
Xilong Gao et al.
Metabolic dysfunction-associated steatotic liver disease [MASLD; previously known as nonalcoholic fatty liver disease (NAFLD)] is a prevalent chronic liver disorder strongly associated with aging, yet the mechanisms underlying age-related h...
LC3-positive extracellular vesicles released from tumor cells promote lung metastasis of breast cancer by inducing vascular permeability [0.03%]
乳腺癌细胞释放的LC3阳性胞外囊泡通过诱导血管通透性促进肺转移
Yuqing Shen,Yi Shen,Xuru Wang et al.
Yuqing Shen et al.
Tight junctions (TJs) between pulmonary vascular endothelial cells (ECs) constitute the physical barrier that impedes the metastasis of tumor cells. We previously reported that circulating microtubule-associated proteins 1A/1B light chain 3...
Understanding the catalytic mechanism of the triazine hydrolase from Arthrobacter aurescens TC1 [0.03%]
铜绿假单胞菌TC1三嗪水解酶的催化机制研究
Maya Mowery-Evans,Grayson Gerlich,Karla Diviesti et al.
Maya Mowery-Evans et al.
The catalytic mechanism of the Zn(II)-dependent triazine hydrolase (TrzN) from Arthrobacter aurescens TC1 was examined by measuring the pH dependence of the Michaelis constants kcat, Km, and kcat/Km, the solvent isotope effect, and the ther...
A comprehensive overview of yeast libraries and their role in advancing cell biology [0.03%]
酵母库的全面概述及其在细胞生物学中的作用
Din Baruch,Maya Schuldiner,Ofir Klein
Din Baruch
Over the past two decades, genome-wide collections of mutants, or libraries, have revolutionized the fields of systems and cell biology by enabling systematic and high-throughput interrogation of gene and protein function. This has been esp...
SARS-CoV-2 nucleocapsid protein variants have differential RNA chaperone activity [0.03%]
SARS-CoV-2核衣壳蛋白变异体具有不同的RNA分子伴侣活性
Sabrina Babl,Julia M Seidel,Fabian Kugler et al.
Sabrina Babl et al.
The single-stranded RNA genome of the SARS-CoV-2 virus is characterized by a complex secondary structure formed by patches of intramolecular RNA double-strands. Here, we show that the nucleocapsid (N) protein is not only the specific viral ...
Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response [0.03%]
肝细胞中MET适度上调可通过促进有效的抗氧化反应来抵御胆汁淤积性肝损伤
Carlos González-Corralejo,Juan García-Sáez,María Figueroa-Fuentes et al.
Carlos González-Corralejo et al.
Hepatocyte growth factor (HGF)/hepatocyte growth factor receptor (MET) signaling plays a critical role during liver regeneration upon acute and chronic damage, and is therefore an interesting target for therapeutic intervention. Nevertheles...
Plant-produced encapsulin displays non-typhoidal Salmonella enterica antigens and assembles into mosaic nanoparticles [0.03%]
植物产生的封装素展示非伤寒沙门氏菌抗原并组装成镶嵌型纳米颗粒
Carly A Charron,Angelo Kaldis,Shabnam Shamriz et al.
Carly A Charron et al.
Foodborne illnesses have major public health and economic impacts. Non-typhoidal Salmonella enterica serovars (Salmonella), associated with the consumption of contaminated poultry products, are among the most common causes of foodborne illn...
Multiple cis-regulatory elements collaborate to control mdka expression in telencephalic neural stem cells of adult zebrafish during constitutive and regenerative neurogenesis [0.03%]
多顺式调控元件协作控制成年斑马鱼脑室下区神经干细胞稳态增殖和损伤后反应性扩增过程中mdka基因表达
Jincan Chen,Masanari Takamiya,Agnes Hendriks et al.
Jincan Chen et al.
Zebrafish is a powerful animal model for studying nervous system regeneration due to its remarkable regenerative abilities and the availability of diverse molecular tools. After telencephalic brain injury, neural stem cells (NSCs) in the ve...
A guide to building the matrisome interactome: from computational predictions to experimental validation [0.03%]
构建矩阵组相互作用网络指南：从计算预测到实验验证
Leanna Leverton,Amanpreet Kaur Bains,Ikram Isa et al.
Leanna Leverton et al.
The extracellular matrix (ECM) is a complex meshwork of proteins and polysaccharides found in all multicellular organisms, that provides structural support to cells and organize them into tissues and organs. In addition to its architectural...
Winter-active spiders (Clubiona) have a hyperactive antifreeze protein with a unique beta-solenoid fold [0.03%]
一种具有独特β-层折叠的活性冬蜘蛛抗冻蛋白
Laurie A Graham,Stano Pekár,Ina M Hainer et al.
Laurie A Graham et al.
Spiders are among the most important natural enemies of pests in orchards. Clubiona spp. are active even during winter, when other pest predators are dormant. Such activity is possible because these spiders produce antifreeze proteins (AFPs...