A guide to mapping ubiquitin and ubiquitin-like E3 ligases to their substrates [0.03%]
泛素和泛素样E3连接酶与其底物的关联指南
Laura Merino-Cacho,Claudia Guinea-Pérez,Mónica Pozo-Rodríguez et al.
Laura Merino-Cacho et al.
Ubiquitination is a post-translational modification that plays a key role in the maintenance of protein homeostasis. Ubiquitin is covalently attached to the target proteins through a three-step enzymatic cascade in which substrate specifici...
Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link [0.03%]
RNase 7在神经元和胶质细胞模型中的作用：走向一个意想不到的新功能联系
Rosanna Culurciello,Maria Cristiano,Ilaria Di Nardo et al.
Rosanna Culurciello et al.
Human ribonuclease 7 (RNase 7), originally isolated from skin, is a member of the RNase A Superfamily and primarily known to be among the endogenous proteins with the most pronounced antimicrobial properties. Nevertheless, to date, studies ...
Dynamic interaction between Escherichia coli enterotoxins and bacteriocins [0.03%]
大肠杆菌肠毒素与细菌素的动态相互作用
Dan Liu,Mengjiao Luo,Mengyao Li et al.
Dan Liu et al.
The intestinal microbiota constitutes a crucial defense barrier against pathogenic invasion; however, the molecular mechanisms enabling pathogens to evade or modulate this defense remain poorly understood. Here, we established a coculture m...
Pml loss worsens NEK1-linked ALS and Pml induction drives NEK1 degradation, precluding disease onset [0.03%]
PML损失恶化与NEK1相关的ALS，并且PML诱导促使NEK1降解，阻止疾病发生
Panagiota Georgiadou,Bahriye Erkaya,Michiko Niwa-Kawakita et al.
Panagiota Georgiadou et al.
Germinal mono-allelic loss-of-function mutations of NEK1 drive amyotrophic lateral sclerosis (ALS) at variable penetrance, presumably through haploinsufficiency. Modeling the ALS-associated Arg812Ter mutation in mice revealed that the resul...
Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small-for-gestational-age placenta [0.03%]
小胎龄胎盘中的类固醇补偿和脂质缺乏以及增强的烟酰胺腺嘌呤二核苷酸补救途径
Serena Xodo,Lorenza Driul,Vanessa Tolotto et al.
Serena Xodo et al.
Fetal growth restriction (FGR) affects approximately 8% of pregnancies in Western countries and is characterised by complex placental adaptations at both metabolic and transcriptional levels. In this study, we integrated RNA sequencing and ...
Human IDO2 exhibits unique binding affinities distinct to those of human IDO1 [0.03%]
人类IDO2表现出与人类IDO1截然不同的结合亲和力
Shunsuke Nogi,Ayumu Takahashi,So Murakami et al.
Shunsuke Nogi et al.
Indoleamine 2,3-dioxygenase 2 (IDO2) is a heme enzyme in the kynurenine pathway that shares high structural similarity with IDO1 but exhibits markedly lower catalytic activity. To clarify the molecular basis of this difference, we performed...
T-bet+ tissue-resident regulatory T cells are enriched in the neonatal mouse liver and promoted by IL-27 and IFN-γ [0.03%]
新生儿小鼠肝脏富含T-bet+定居型调节性T细胞并可由IL-27和IFN-γ促进
Lijun Yang,Yujia Wang,Mingyang Li et al.
Lijun Yang et al.
Neonatal regulatory T (Treg) cells in secondary lymphoid organs have greater proliferative capacity and more potent suppressive functions than adult Treg cells. However, the phenotypic and functional features of Tregs in neonatal nonlymphoi...
Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS-3 [0.03%]
来源于Thermoleophilum album YS-3的羧酸酯酶的聚酯酶活性及热稳定性
Tatyana N Chernikova,Anna N Khusnutdinova,Hairong Ma et al.
Tatyana N Chernikova et al.
Recently, enzymatic depolymerisation of synthetic polyesters has emerged as an attractive complement to current plastic recycling methods. However, the arsenal of robust enzymes available for these applications remains limited. Here, we ide...
Hajrah Khawaja,Yeliz Yilmaz,Julija Hmeljak
Hajrah Khawaja
The FEBS Journal's Editorial Office is delighted to present our first Focus Issue of the year. In this Issue, we highlight some excellent research that advances the field of molecular microbiology. We welcome you to this celebration of all ...
Editorial
The FEBS journal. 2026 Mar 6. DOI:10.1111/febs.70481 2026
Hans V Westerhoff,Barbara M Bakker,Andreas S Bommarius et al.
Hans V Westerhoff et al.
Chemical potentials (molar Gibbs energies) are usually extrapolated to the remote physical-chemical reference state and then stored. Subsequent use under in vivo conditions requires a similarly substantial, reverse extrapolation, again with...