Laura Morette,Fanny Marceau,Sandrine Mathiot et al.
Laura Morette et al.
Glutathione transferases (GSTs) constitute a widespread superfamily of multifunctional enzymes with roles in cellular detoxification and secondary metabolism. We report that the poorly characterized Iota-class enzymes (GSTIs) are mainly fou...
Deubiquitinase inhibitors: Targeting SARS-CoV-2 papain-like protease with antiviral efficacy in a murine model [0.03%]
特异性靶向冠状病毒去泛素酶抑制剂体内抗病毒活性评价
Shweta Choudhary,Sanketkumar Nehul,Santhosh Kambaiah Nagaraj et al.
Shweta Choudhary et al.
SARS-CoV-2 papain-like protease (PLpro) is a key antiviral target as it plays a dual role in viral replication and modulation of innate immune responses by deubiquitinating or deISGylating host proteins. Therefore, therapeutically targeting...
A miRNA screen reveals a transcriptional network controlling the initiation of mammary organoids [0.03%]
长非编码RNA和microRNAs调节小鼠乳腺类器官发生的转录网络筛查
Jacques Robert,Lena Gosset,Efstathios-Iason Vlachavas et al.
Jacques Robert et al.
Organoid formation is driven by poorly understood intrinsic cellular properties and transcriptional programs that govern plasticity and differentiation. Deciphering these regulatory networks is essential for understanding normal tissue home...
Mitochondrial uncoupler BAM15 ameliorates liver lipid metabolism disorders by activating the AMPK pathway [0.03%]
线粒体解偶联剂BAM15通过激活AMPK信号通路改善肝脏脂代谢紊乱
Zunhai Liu,Wentao Wang,Simeng Wang et al.
Zunhai Liu et al.
N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (BAM15) is a recently identified mitochondrial uncoupler with antitumor, anti-inflammatory, antioxidant and antiobesity properties. Although it has been shown that BAM15...
Capillary differences with age and muscle fiber type are attenuated by accounting for fiber shape [0.03%]
通过校正纤维形状后年龄和肌纤维类型间的血管差异被削弱
Jonathan F Frydenholm,Cecilie J L Bechshøft,Michael Kjaer et al.
Jonathan F Frydenholm et al.
Age-related declines in skeletal muscle capillarization are well-documented, yet commonly used indices, such as the capillary-to-fiber perimeter exchange index (CFPE), assume uniform myofiber shape. Because fiber size and shape changes with...
Phycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases [0.03%]
酸菌硫化菊红螺素生物合成需要由bilin reductase催化生成的藻红素红螺素异构体
Federica Frascogna,Nathan C Rockwell,Jana Hartmann et al.
Federica Frascogna et al.
Phycobiliproteins are essential components of the light-harvesting antennae in cyanobacteria and red algae, requiring covalently bound open-chain tetrapyrrole chromophores (bilins) for proper function. In the red alga Galdieria sulphuraria,...
Huma Rahil,Albert Weixlbaumer
Huma Rahil
Recruitment of the small ribosomal subunit (30S) to messenger RNA (mRNA) marks a key step in bacterial translation initiation. Recruitment begins with a 30S standby site binding single-stranded mRNA regions at or near the translation initia...
Targeting the histone-fold dimerization interface of oocyst rupture proteins from Plasmodium berghei for antimalarial inhibitor discovery [0.03%]
针对伯氏疟原虫子孢子裂解蛋白组氨酸褶皱二聚化界面的抗疟新药发现研究
Federico Ballabio,Chiara Bertaso,Marta Villa et al.
Federico Ballabio et al.
Dimerization between the histone-fold domains (HFD) of two Plasmodium Oocyst Rupture Proteins (ORP1 and ORP2) is essential for oocyst rupture in the Anopheles mosquito vector host, representing a key event in parasite transmission to humans...
A Hanks-type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation [0.03%]
Hanks型细菌激酶PknS通过直接磷酸化替代σ因子EcfK促进对原生动物捕食的抗性
Lídia Dos Passos Lima,Dev Sriranganadane,Daiane Laise da Silva et al.
Lídia Dos Passos Lima et al.
Serine/threonine (Ser/Thr) kinases of the Hanks-type family are widespread in bacteria, playing key roles in signal transduction. The transmembrane Ser/Thr kinase PknS (XAC4127) from the phytopathogenic bacterium Xanthomonas citri is requir...
Liver-specific BAG3 knockout delays chemically induced hepatocellular carcinoma development [0.03%]
肝特异性BAG3敲除延迟化学诱导的肝细胞癌的发生发展
Verena Damiani,Erika Pizzinato,Federica Di Marco et al.
Verena Damiani et al.
Bcl-2-associated athanogene 3 (BAG3) is a multifunctional protein involved in several cellular processes, including protein folding, degradation, apoptosis regulation, and cytoskeleton dynamics. Its dysregulation has been associated with se...