Tisya Banerjee,Hajrah Khawaja,Julija Hmeljak
Tisya Banerjee
To celebrate the launch of our latest Focus Issue on molecular microbiology, we have chosen to highlight a few of our favourite microbiology articles from our recent archive. The papers discussed here showcase the power of fundamental disco...
Opposing roles of DGAT-mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity [0.03%]
DGAT介导的脂滴生物发生通过调节铁死亡敏感性发挥相反的作用
Ana Kump,Leja Perne,Špela Koren et al.
Ana Kump et al.
Lipid droplets (LDs) are dynamic fat storage organelles involved in fatty acid metabolism, signaling, and trafficking. By storing polyunsaturated fatty acids (PUFAs) in the form of neutral lipids, LDs can either mitigate or exacerbate lipot...
A noncanonical role for Jagged1 in endothelial mechanotransduction [0.03%]
Notch配体Jagged1在内皮细胞力学信号转导中的非经典作用
Freddy Suarez Rodriguez,Noora Virtanen,Elmeri Kiviluoto et al.
Freddy Suarez Rodriguez et al.
The Notch signaling pathway plays a crucial role in regulating endothelial biology. Notch signaling is sensitive to hemodynamic forces and governs mechanically driven cardiovascular development, physiology, and remodeling. However, the mech...
Holding but not folding: How a single charge flip uncouples the DNAJC7-Hsp70 relay in amyotrophic lateral sclerosis [0.03%]
单个电荷翻转如何使DNAJC7-Hsp70肌萎缩侧索硬化症中的分子继电器解耦
Tsung-Sheng Chiang,Jerome Boisbouvier,Lauren A Gandy
Tsung-Sheng Chiang
Genetic mutations impact protein function through various routes: Some catalyze new oncogenic activities, while others trigger complete structural collapse. However, the E425K mutation in DNAJC7, associated with Amyotrophic Lateral Sclerosi...
Lea Dörner,Catrin Lutz,Stefan Prekovic et al.
Lea Dörner et al.
Cancer is increasingly recognised as a complex and heterogeneous disease, shaped not only by genetic mutations but also by the physical and biochemical context in which tumours develop. The spatial position of a cell, including its physical...
Coordinated translation initiation determines -1 programmed ribosomal frameshifting efficiency of chromosomal genes to impact on cell fitness [0.03%]
协同识别的翻译起始决定染色体基因-1程序化核糖体框移效率以影响细胞适应性
Sih-Yun Tai,Masayuki Hashimoto,Yi-Fang Zhuang et al.
Sih-Yun Tai et al.
The conserved -1 programmed ribosomal frameshifting (-1PRF), essential for eubacteria and RNA viruses, is thought to be exclusively regulated during translation elongation. One of the two required -1PRF cis-acting elements is a frameshiftin...
Disruption of the ∆40p53/miR-4671-5p/SGSH axis results in intra-S-phase arrest and poor cancer prognosis [0.03%]
∆40p53/miR-4671-5p/SGSH轴紊乱导致S期滞留并预示著较差的癌症预后
Apala Pal,Pritam Kumar Ghosh,Sahana Ghosh et al.
Apala Pal et al.
Parsing the functions of the tumor suppressor tumor protein p53 (TP53) is complex due to the multiple isoforms it encodes. ∆40p53, an N-terminally truncated p53 isoform and the only translational isoform, modulates full-length p53 (FLp53) ...
Ischaemia/reperfusion and permanent ischaemia differentially affect haemoglobin properties - Possible influence of oxidative stress and adaptation to acute hypoxia [0.03%]
缺血/再灌注和永久性缺血对血红蛋白性质的影响不同-氧化应激和急性缺氧适应作用的可能影响
Zhanna V Bochkova,Margarita A Khlystova,Veronika A Katrukha et al.
Zhanna V Bochkova et al.
Cerebral ischaemia is an acute state characterised by a severe decrease in the supply of oxygen (O2) to the brain, resulting in the death of neurons and glial cells. Despite multiple studies investigating the processes that lead to cell dam...
Interactions between small leucine-rich proteoglycans and proteases: implications for tissue homeostasis and pathology [0.03%]
小型富亮氨酸多聚蛋白与蛋白酶之间的相互作用及其对组织稳态和病理的影响
Maria Konstantaraki,Lydia-Nefeli Thrapsanioti,Aikaterini Berdiaki et al.
Maria Konstantaraki et al.
Small leucine-rich proteoglycans (SLRPs) are essential regulators of extracellular matrix (ECM) organization and cell signaling. Beyond their structural roles, SLRPs modulate protease activity or serve as their substrates, thereby influenci...
Daniel Herschlag,Siyuan Du
Daniel Herschlag
In this perspective, we describe how we arrived at a framework of ensemble-function analyses to quantitatively dissect enzyme catalysis and biological function more broadly. Serine proteases are described in biochemistry textbooks to illust...