Intrinsic specificity of a 'core' TIP60 acetyltransferase complex in Drosophila [0.03%]
果蝇中“核心”TIP60乙酰转移酶复合体的内在特异性
Silke Krause,Marco Borsò,Marisa Müller et al.
Silke Krause et al.
The acetylation of histones is a central component of reversible chromatin modification that governs genome regulation. Understanding the complex histone acetylation network requires knowledge about the contributions of individual acetyltra...
Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide-dependent enzyme in the archaeal mevalonate pathway [0.03%]
解析古菌甲羟戊酸途径中牻牛儿基单核苷酸依赖型无水我醇酸磷酸酯脱羧酶的性质和反应机制
Rino Ishikawa,Natsumi Matsushima,Soma Ishimine et al.
Rino Ishikawa et al.
In the archaeal mevalonate pathway, the prototype of all existing mevalonate pathways, a unique intermediate, trans-anhydromevalonate phosphate, is decarboxylated to form isopentenyl phosphate. The key reaction is catalyzed by a 3-octapreny...
So Yeon Lee,Hyun Ho Park
So Yeon Lee
CRISPR-Cas systems provide adaptive immunity to bacteria, although bacteriophages counter these defenses with anti-CRISPR (Acr) proteins. Acr expression is frequently regulated by anti-CRISPR associated (Aca) proteins, which repress transcr...
Coenzyme A mitigates cystine-deprivation-induced ferroptosis by suppressing the iron-starvation response [0.03%]
辅酶A通过抑制缺铁反应缓解胱氨酸缺乏诱导的铁死亡
Mingjun Tan,Yunzhan Li,Lei Sang et al.
Mingjun Tan et al.
The labile iron pool in the cell is required for ferroptosis, a form of regulated cell death resulting from excessive lipid peroxidation and membrane damage. Glutathione (GSH) is critical for lipid-peroxide scavenging, and cysteine is the r...
A perilysosomal feedforward mechanism regulates starvation-induced calcium signaling [0.03%]
溶酶体危险信号机制调节饥饿诱导的钙离子信号转导
Jennifer Giles,Abbie Sesker,Marcos Gonzalez et al.
Jennifer Giles et al.
Nutrient depletion triggers a starvation-induced calcium (Ca2+) signal (SICS) that promotes Ca2+-dependent responses. However, the components and regulations of SICS are unclear. Here, we explored SICS components and their regulation by the...
Surface loops may provide additional function necessary for enzyme-to-pseudoenzyme transition in the fungal metallocarboxypeptidase family [0.03%]
表面环路可能为真菌金属羧肽酶家族中的酶到伪酶转变提供必要功能
Zhiheng Zhao,Faith C Kaluba,Peter J Lyons
Zhiheng Zhao
The transition from enzyme to pseudoenzyme is thought to begin with moonlighting enzymes that have gained nonenzymatic functions. Subsequent gene duplication events allow for the separation of enzyme and pseudoenzyme function. We explored t...
In vitro affinity maturation of a single-chain antibody against thyroxine based on computer-aided design [0.03%]
基于计算机辅助设计的单链抗体甲状腺素体外亲和力成熟优化
Meilun Chen,Yijie Liu,Zheng Wei et al.
Meilun Chen et al.
Thyroxine (T4) plays a crucial role in regulating various physiological functions in the human body. As a key biomolecule for molecular recognition, single-chain variable fragments (scFvs) offer advantages, such as small molecular size, hig...
The ALS-associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle [0.03%]
ALS关联的E425K突变使DNAJC7脱离Hsp70分子伴侣循环
Bar Elmaleh,Ofrah Faust,Rina Rosenzweig
Bar Elmaleh
DNAJC7, a member of the J-domain protein (JDP/Hsp40) family, plays a key role in protein homeostasis by regulating Hsp70 activity and preventing protein aggregation. Mutations in DNAJC7 have been linked to amyotrophic lateral sclerosis (ALS...
The FEBS Journal in 2026: Safeguarding scientific integrity amid the rise of the machines [0.03%]
在机器崛起的时代保障科学诚信——《FEBS杂志》2026年展望
Seamus J Martin
Seamus J Martin
The FEBS Journal publishes primary papers and reviews relating to the molecules and mechanisms underpinning biological processes. Editor-in-Chief Seamus Martin discusses some of the challenges posed by the increasing use of generative AI to...