Pyridine(diimine) Iron Diene Complexes Relevant to Catalytic [2+2]-Cycloaddition Reactions [0.03%]
与催化[2+2]环加成反应相关的吡啶二亚胺铁二烯配合物
C Rose Kennedy,Hongyu Zhong,Matthew V Joannou et al.
C Rose Kennedy et al.
The synthesis, characterization, and catalytic activity of pyridine(diimine) iron piperylene and isoprene complexes are described. These diene complexes are competent precatalysts for (i) the selective cross-[2+2]-cycloaddition of butadiene...
Continuous Flow Bioamination of Ketones in Organic Solvents at Controlled Water Activity using Immobilized ω-Transaminases [0.03%]
利用固定化ω-转氨酶以可控水活度在有机溶剂中连续流动生物胺化酮类化合物
Wesley Böhmer,Alexey Volkov,Karim Engelmark Cassimjee et al.
Wesley Böhmer et al.
Compared with biocatalysis in aqueous media, the use of enzymes in neat organic solvents enables increased solubility of hydrophobic substrates and can lead to more favorable thermodynamic equilibria, avoidance of possible hydrolytic side r...
Technology Trends of Catalysts in Hydrogenation Reactions: A Patent Landscape Analysis [0.03%]
氢化反应催化剂技术发展趋势：基于专利文献的分析研究
Marius A Stoffels,Felix J R Klauck,Thomas Hamadi et al.
Marius A Stoffels et al.
The purpose of this review is to present an overview of the patent landscape for catalysts used in hydrogenation reactions. Based on patent data extracted from PatBase®, we use predefined patent classifications as well as a keyword-based s...
B(C6F5)3-Catalyzed α-Deuteration of Bioactive Carbonyl Compounds with D2O [0.03%]
B(C6F5)3催化生物活性羰基化合物的D2Oα-氘代反应
Yejin Chang,Tanner Myers,Masayuki Wasa
Yejin Chang
An efficient deuteration process of α-C-H bonds in various carbonyl-based pharmaceutical compounds has been developed. Catalytic reactions are initiated by the action of Lewis acidic B(C6F5)3 and D2O, converting a drug molecule into the co...
Site-Selective Nitrene Transfer to Conjugated Olefins Directed by Oxazoline Peptide Ligands [0.03%]
由噁唑啉肽配体导向的位点选择性亚胺基离子转移加成反应构建共轭烯烃中的碳氮键
Golo Storch,Naudin van den Heuvel,Scott J Miller
Golo Storch
Site-selective nitrene transfer to di- and polyene substrates has been achieved using designed peptide-embedded bioxazoline ligands capable of binding copper. In model 1,3-diene substrates, the olefinic position proximal to a directing grou...
Chemoselective Tertiary C-H Hydroxylation for Late-Stage Functionalization with Mn(PDP)/Chloroacetic Acid Catalysis [0.03%]
锰催化三烷基碳氢选择性羟基化反应晚期功能化合成化合物
Rachel K Chambers,Jinpeng Zhao,Connor P Delaney et al.
Rachel K Chambers et al.
Aromatic and heterocyclic functionality are ubiquitous in pharmaceuticals. Herein, we disclose a new Mn(PDP)catalyst system using chloroacetic acid additive capable of chemoselectively oxidizing remote tertiary C(sp 3)-H bonds in the presen...
Pd/BIPHEPHOS is an Efficient Catalyst for the Pd-Catalyzed S-Allylation of Thiols with High n-Selectivity [0.03%]
高n选择性硫代烷基化反应高效催化剂Pd/BIPHEPHOS的发现
Thomas Schlatzer,Hilmar Schröder,Melanie Trobe et al.
Thomas Schlatzer et al.
The Pd-catalyzed S-allylation of thiols with stable allylcarbonate and allylacetate reagents offers several advantages over established reactions for the formation of thioethers. We could demonstrate that Pd/BIPHEPHOS is a catalyst system w...
Biocatalytic Enantioselective Oxidation of Sec-Allylic Alcohols with Flavin-Dependent Oxidases [0.03%]
flavin依赖型氧化酶催化的 sec-烯丙醇的不对称氧化
Somayyeh Gandomkar,Etta Jost,Doris Loidolt et al.
Somayyeh Gandomkar et al.
The oxidation of allylic alcohols is challenging to perform in a chemo- as well as stereo-selective fashion at the expense of molecular oxygen using conventional chemical protocols. Here, we report the identification of a library of flavin-...
Old Concepts, New Application - Additive-Free Hydrogenation of Nitriles Catalyzed by an Air Stable Alkyl Mn(I) Complex [0.03%]
旧概念新应用——空气稳定性的烷基锰(i)催化剂催化的无添加剂腈氢化反应
Stefan Weber,Luis F Veiros,Karl Kirchner
Stefan Weber
An efficient additive-free manganese-catalyzed hydrogenation of nitriles to primary amines with molecular hydrogen is described. The pre-catalyst, a well-defined bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dpre)(CO)3(CH3)] (dpre=1...
Cyclopropanation of Benzene Rings by Oxidatively Generated α-Oxo Gold Carbene: One-Pot Access to Tetrahydropyranone-Fused Cycloheptatrienes from Propargyl Benzyl Ethers [0.03%]
通过氧化生成的α-氧代金卡宾进行苯环环丙烷化： propargyl benzyl ethers合成四氢吡喃并环庚三烯的一锅法
Kegong Ji,Liming Zhang
Kegong Ji
Cyclopropanations of benzene rings by oxidatively generated α-oxo gold carbenes are for the first time demonstrated in a Buchner reaction, in which readily available propargyl benzyl ethers are converted in one-pot to tetrahydropyranone-fu...