Site-Selective Nitrene Transfer to Conjugated Olefins Directed by Oxazoline Peptide Ligands [0.03%]
由噁唑啉肽配体导向的位点选择性亚胺基离子转移加成反应构建共轭烯烃中的碳氮键
Golo Storch,Naudin van den Heuvel,Scott J Miller
Golo Storch
Site-selective nitrene transfer to di- and polyene substrates has been achieved using designed peptide-embedded bioxazoline ligands capable of binding copper. In model 1,3-diene substrates, the olefinic position proximal to a directing grou...
Chemoselective Tertiary C-H Hydroxylation for Late-Stage Functionalization with Mn(PDP)/Chloroacetic Acid Catalysis [0.03%]
锰催化三烷基碳氢选择性羟基化反应晚期功能化合成化合物
Rachel K Chambers,Jinpeng Zhao,Connor P Delaney et al.
Rachel K Chambers et al.
Aromatic and heterocyclic functionality are ubiquitous in pharmaceuticals. Herein, we disclose a new Mn(PDP)catalyst system using chloroacetic acid additive capable of chemoselectively oxidizing remote tertiary C(sp 3)-H bonds in the presen...
Pd/BIPHEPHOS is an Efficient Catalyst for the Pd-Catalyzed S-Allylation of Thiols with High n-Selectivity [0.03%]
高n选择性硫代烷基化反应高效催化剂Pd/BIPHEPHOS的发现
Thomas Schlatzer,Hilmar Schröder,Melanie Trobe et al.
Thomas Schlatzer et al.
The Pd-catalyzed S-allylation of thiols with stable allylcarbonate and allylacetate reagents offers several advantages over established reactions for the formation of thioethers. We could demonstrate that Pd/BIPHEPHOS is a catalyst system w...
Biocatalytic Enantioselective Oxidation of Sec-Allylic Alcohols with Flavin-Dependent Oxidases [0.03%]
flavin依赖型氧化酶催化的 sec-烯丙醇的不对称氧化
Somayyeh Gandomkar,Etta Jost,Doris Loidolt et al.
Somayyeh Gandomkar et al.
The oxidation of allylic alcohols is challenging to perform in a chemo- as well as stereo-selective fashion at the expense of molecular oxygen using conventional chemical protocols. Here, we report the identification of a library of flavin-...
Old Concepts, New Application - Additive-Free Hydrogenation of Nitriles Catalyzed by an Air Stable Alkyl Mn(I) Complex [0.03%]
旧概念新应用——空气稳定性的烷基锰(i)催化剂催化的无添加剂腈氢化反应
Stefan Weber,Luis F Veiros,Karl Kirchner
Stefan Weber
An efficient additive-free manganese-catalyzed hydrogenation of nitriles to primary amines with molecular hydrogen is described. The pre-catalyst, a well-defined bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dpre)(CO)3(CH3)] (dpre=1...
Cyclopropanation of Benzene Rings by Oxidatively Generated α-Oxo Gold Carbene: One-Pot Access to Tetrahydropyranone-Fused Cycloheptatrienes from Propargyl Benzyl Ethers [0.03%]
通过氧化生成的α-氧代金卡宾进行苯环环丙烷化： propargyl benzyl ethers合成四氢吡喃并环庚三烯的一锅法
Kegong Ji,Liming Zhang
Kegong Ji
Cyclopropanations of benzene rings by oxidatively generated α-oxo gold carbenes are for the first time demonstrated in a Buchner reaction, in which readily available propargyl benzyl ethers are converted in one-pot to tetrahydropyranone-fu...
Progress in Difluoroalkylation of Organic Substrates by Visible Light Photoredox Catalysis [0.03%]
可见光促进的有机底物双氟烷基化反应研究进展
Agostinho Lemos,Christian Lemaire,André Luxen
Agostinho Lemos
The selective incorporation of fluorinated motifs, in particular CF2FG (FG=a functional group) and CF2H groups, into organic compounds has attrracted increasing attention since organofluorine molecules are of the utmost importance in the ar...
Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes [0.03%]
醛缩酶催化简单脂肪族亲核试剂与氨基甲醛的加成反应构建手性N-杂环化合物
Raquel Roldán,Karel Hernández,Jesús Joglar et al.
Raquel Roldán et al.
Nitrogen heterocycles are structural motifs found in many bioactive natural products and of utmost importance in pharmaceutical drug development. In this work, a stereoselective synthesis of functionalized N-heterocycles was accomplished in...
Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N- Acetylneuraminate Lyase in a Continuous Flow Reactor [0.03%]
固定化N-乙酰神经氨酸酶在连续流动反应器中合成唾液酸衍生物的化学酶法
Victor R L J Bloemendal,Sam J Moons,Jurriaan J A Heming et al.
Victor R L J Bloemendal et al.
The synthesis of N-acetylneuraminic acid (Neu5Ac) derivatives is drawing more and more attention in glycobiology research because of the important role of sialic acids in e. g. cancer, bacterial, and healthy cells. Chemical preparation of t...
Stereoselective Synthesis of 3-Oxabicyclo[3.3.1]nonan-2-ones via a Domino Reaction Catalyzed by Modularly Designed Organocatalysts [0.03%]
模块化设计 organocatalysts催化的串联反应合成3-氧杂双环[3.3.1]壬内酮类化合物的立体选择性合成研究
Ramarao Parella,Satish Jakkampudi,Hadi Arman et al.
Ramarao Parella et al.
A highly stereoselective method for the synthesis of functionalized 3-oxabicyclo[3.3.1]nonan-2-one derivatives with four contiguous stereogenic centers, including one tetrasubstituted stereogenic center, was realized through an organocataly...