Synthesis of Indolyl-7-azanorbornanes by Decomposition of Tetrahydro-1,2,3-triazepines [0.03%]
四氢-1,2,3-三氮杂环戊烯的分解反应合成茚并庚氮卓化合物
Zachary Protich,Samuel J Touchette,Jimmy Wu
Zachary Protich
We report a new method for the synthesis of indolyl-7-azanobornanes. The process involves the generation of a meta-stable tetrahydro-1,2,3-triazepine intermediate that decomposes by extrusion of molecular nitrogen and ultimately leads to th...
Selectivity Rules for the Dearomative (3+2) Annulation Reaction Between Substituted Indoles and Oxyallyl Cations [0.03%]
取代吲哚与氧亚烯基阳离子的去芳构化(3+2)环化反应的选择性规律
Dhiman Saha,Jimmy Wu
Dhiman Saha
We report a collection of "selectivity rules" for the dearomative (3+2) annulation reaction between substituted indoles and oxyallyl cations. The application of these rules enables us to synthesize four different regioisomeric permutations ...
Phosphorus Fluoride Exchange (PFEx) Click Chemistry: 2-Substituted-alkynyl-1-cyclotriphosphazene (SACP) Hubs for Diversity Oriented Clicking [0.03%]
用于多样化的点击化学的含磷氟交换(SACP)中心体：2-取代乙炔基-1-三氮杂磷烷化合物(SACP)
Zifei Wang,Dharmendra S Vishwakarma,Shoujun Sun et al.
Zifei Wang et al.
Phosphorus Fluoride Exchange (PFEx) is a new click chemistry technology that hinges on the creation of innovative hubs to unlock its potential and broaden its applications. In this study, we outline some guiding principles for PFEx hub deve...
Benzene-1,3-disulfonyl fluoride and Benzene-1,3,5-trisulfonyl fluoride: Low-Cost, Stable, and Selective Reagents for SuFEx-Driven Deoxyazidation [0.03%]
苯-1,3-二磺酰氟和苯-1,3,5-三磺酰氟：SuFEx驱动脱氧叠氮化反应的低成本、稳定且高效的试剂
Dharmendra S Vishwakarma,John E Moses
Dharmendra S Vishwakarma
The development of synthetic methods for the synthesis of organic azides is highly important, given their critical role in advancing click chemistry over the last twenty years. We report a reagent-economical, reliable, and scalable synthesi...
Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity [0.03%]
曼尼希型缩合与多米诺喹唑啉酮-脒重排生成具有抗阿米巴活性的环融合Mackinazolinones
Matthew S Lish,Jillian E Milanes,Kyana M Sanders et al.
Matthew S Lish et al.
A three-step synthesis of anti-amoebic, ring-fused mackinazolinones has been developed. A Mannich-type reaction between quinazolin-4-ones and N-Cbz propanal in the presence of AgOTf afforded quinazolinones (19-94% isolated yield) bearing a ...
n-Bu4NI/K2S2O8 Mediated Csp2-Csp2 Bond Cleavage - Transformylation from p-Anisaldehyde to Primary Amides [0.03%]
n-Bu4NI/K2S2O8介导的C(sp2)-C(sp2)键断裂——从对甲氧基苯甲醛到一级酰胺的转烷基化反应
Xiaochen Liu,Samual Hee,Netanel G Sapir et al.
Xiaochen Liu et al.
n-Bu4NI/K2S2O8 mediated transformylation from p-anisaldehyde to primary amides is reported. The mechanistic studies suggest the reaction occurs via a single electron transfer pathway. Based on the DFT electronic structure calculations of va...
Enantioselective Syntheses of 3,4-Dihydropyrans Employing Isochalcogenourea-Catalyzed Formal (4+2)-Cycloadditions of Allenoates [0.03%]
异噁二硫𬭩盐催化 Allenoate 的形式环加成反应合成手性四氢吡喃类化合物
Magdalena Piringer,Mario Hofer,Lukas S Vogl et al.
Magdalena Piringer et al.
We herein successfully demonstrate the use of chiral isochalcogenoureas as Lewis Base catalysts for a variety of (4+2)-cycloaddition reactions of allenoates and different Michael acceptors. In all cases the same structural key-motive, a dih...
Mathias Pickl,Markus Ebner,Samantha Gittings et al.
Mathias Pickl et al.
Although optical pure amino alcohols are in high demand due to their widespread applicability, they still remain challenging to synthesize, since commonly elaborated protection strategies are required. Here, a multi-enzymatic methodology is...
Merger of Visible Light-Driven Chiral Organocatalysis and Continuous Flow Chemistry: An Accelerated and Scalable Access into Enantioselective α-Alkylation of Aldehydes [0.03%]
光驱动手性有机催化与连续流动化学的融合——醛的高选择性动态动力学拆分α-烷基化反应实现一步加速放大合成
Márk Molnár,C Oliver Kappe,Sándor B Ötvös
Márk Molnár
The electron donor-acceptor complex-enabled asymmetric photochemical alkylation strategy holds potential to attain elusive chiral α-alkylated aldehydes without an external photoredox catalyst. The photosensitizer-free conditions are benefi...
Pengzhi Wang,Anna V Bay,Emelia J Farnam et al.
Pengzhi Wang et al.
A mild photocatalyzed approach to achieve the α-alkylation of esters via formation of an α -radical is disclosed here. Cesium enolates of esters were generated in situ using Cs2CO3 as a base. A subsequent photocatalyzed oxidation at the ...