Wen Yang,Jian Guo,Samual Hee et al.
Wen Yang et al.
Over the past two decades, iodine-mediated free radical reactions have been extensively explored and employed in chemical transformations that complement traditional ionic reactions. In this review, we have updated the progress of the iodin...
Ligand and Substrate Effects on Regio- and Stereoselective Ru(II)-Catalyzed Hydroacyloxylations to Vinylic Esters [0.03%]
配体和底物对Ru(II)催化羟基氧化酯化反应区域选择性和立体选择性的影响研究——通往烯基酯的新方法
Paul A Beasley,Frank E McDonald
Paul A Beasley
Two Ru(II)-catalytic systems were developed for anti-Markovnikov regioselective hydroacyloxylations of terminal alkynes to vinylic esters. [Ru(NCCH3)6][(BF4)2] favors (E)-vinylic ester products with arylacetylenes and select carboxylic acid...
Three-Component Synthesis of γ-Amino Esters with α-Quaternary Carbon Centers via NHC/Photoredox Dual Catalysis [0.03%]
用于合成含α-四级碳中心的γ-氨基酸酯的三组分NHC/光氧化还原催化体系
Adam X Wayment,Karl A Scheidt
Adam X Wayment
γ-Amino acid derivatives are important motifs in medicinal chemistry and have shown wide applicability as inhibitory neurotransmitters. An important class of these compounds feature α,α-disubstitution. However, established routes for the...
Tyler D Weinhold,James A Law,James H Frederich
Tyler D Weinhold
Azetidines are valuable nitrogenous heterocycles. Herein, we disclose a strategy for the modular assembly of 3-azetidines and related spirocyclic congeners featuring all-carbon quaternary centers. This approach leverages titanacyclobutanes ...
Synthesis of Indolyl-7-azanorbornanes by Decomposition of Tetrahydro-1,2,3-triazepines [0.03%]
四氢-1,2,3-三氮杂环戊烯的分解反应合成茚并庚氮卓化合物
Zachary Protich,Samuel J Touchette,Jimmy Wu
Zachary Protich
We report a new method for the synthesis of indolyl-7-azanobornanes. The process involves the generation of a meta-stable tetrahydro-1,2,3-triazepine intermediate that decomposes by extrusion of molecular nitrogen and ultimately leads to th...
Selectivity Rules for the Dearomative (3+2) Annulation Reaction Between Substituted Indoles and Oxyallyl Cations [0.03%]
取代吲哚与氧亚烯基阳离子的去芳构化(3+2)环化反应的选择性规律
Dhiman Saha,Jimmy Wu
Dhiman Saha
We report a collection of "selectivity rules" for the dearomative (3+2) annulation reaction between substituted indoles and oxyallyl cations. The application of these rules enables us to synthesize four different regioisomeric permutations ...
Phosphorus Fluoride Exchange (PFEx) Click Chemistry: 2-Substituted-alkynyl-1-cyclotriphosphazene (SACP) Hubs for Diversity Oriented Clicking [0.03%]
用于多样化的点击化学的含磷氟交换(SACP)中心体：2-取代乙炔基-1-三氮杂磷烷化合物(SACP)
Zifei Wang,Dharmendra S Vishwakarma,Shoujun Sun et al.
Zifei Wang et al.
Phosphorus Fluoride Exchange (PFEx) is a new click chemistry technology that hinges on the creation of innovative hubs to unlock its potential and broaden its applications. In this study, we outline some guiding principles for PFEx hub deve...
Benzene-1,3-disulfonyl fluoride and Benzene-1,3,5-trisulfonyl fluoride: Low-Cost, Stable, and Selective Reagents for SuFEx-Driven Deoxyazidation [0.03%]
苯-1,3-二磺酰氟和苯-1,3,5-三磺酰氟：SuFEx驱动脱氧叠氮化反应的低成本、稳定且高效的试剂
Dharmendra S Vishwakarma,John E Moses
Dharmendra S Vishwakarma
The development of synthetic methods for the synthesis of organic azides is highly important, given their critical role in advancing click chemistry over the last twenty years. We report a reagent-economical, reliable, and scalable synthesi...
Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity [0.03%]
曼尼希型缩合与多米诺喹唑啉酮-脒重排生成具有抗阿米巴活性的环融合Mackinazolinones
Matthew S Lish,Jillian E Milanes,Kyana M Sanders et al.
Matthew S Lish et al.
A three-step synthesis of anti-amoebic, ring-fused mackinazolinones has been developed. A Mannich-type reaction between quinazolin-4-ones and N-Cbz propanal in the presence of AgOTf afforded quinazolinones (19-94% isolated yield) bearing a ...
n-Bu4NI/K2S2O8 Mediated Csp2-Csp2 Bond Cleavage - Transformylation from p-Anisaldehyde to Primary Amides [0.03%]
n-Bu4NI/K2S2O8介导的C(sp2)-C(sp2)键断裂——从对甲氧基苯甲醛到一级酰胺的转烷基化反应
Xiaochen Liu,Samual Hee,Netanel G Sapir et al.
Xiaochen Liu et al.
n-Bu4NI/K2S2O8 mediated transformylation from p-anisaldehyde to primary amides is reported. The mechanistic studies suggest the reaction occurs via a single electron transfer pathway. Based on the DFT electronic structure calculations of va...