Chemoenzymatic Production of Enantiocomplementary 2-Substituted 3-Hydroxycarboxylic Acids from L-α-Amino Acids [0.03%]
利用L-α-氨基酸制备对映体互补的2-取代-3-羟基羧酸的化学酶法
Mathias Pickl,Roser Marín-Valls,Jesús Joglar et al.
Mathias Pickl et al.
A two-enzyme cascade reaction plus in situ oxidative decarboxylation for the transformation of readily available canonical and non-canonical L-α-amino acids into 2-substituted 3-hydroxy-carboxylic acid derivatives is described. The biocata...
Enantioselective Kinetic Resolution/Desymmetrization of Para-Quinols: A Case Study in Boronic-Acid-Directed Phosphoric Acid Catalysis [0.03%]
对位奎놀的动力学拆分/非对称合成：硼酸控制磷酸催化的一个案例研究
Banruo Huang,Ying He,Mark D Levin et al.
Banruo Huang et al.
A chiral phosphoric acid-catalyzed kinetic resolution and desymmetrization of para-quinols operating via oxa-Michael addition was developed and subsequently subjected to mechanistic study. Good to excellent s-factors/enantioselectivities we...
Radical-Polar Crossover Annulation: A Platform for Accessing Polycyclic Cyclopropanes [0.03%]
极性交叉开环反应构建多环化合物
John A Milligan,Kevin L Burns,Anthony V Le et al.
John A Milligan et al.
Photoredox-mediated radical/polar crossover (RPC) processes provide unique solutions to challenging annulations. Herein, we describe an approach to the cyclopropanation of olefins that are embedded within bicyclic scaffolds. Whereas these s...
Enantioselective Bifunctional Ammonium Salt-Catalyzed Syntheses of 3-CF3S-, 3-RS-, and 3-F-Substituted Isoindolinones [0.03%]
高选择性双功能
Andreas Eitzinger,Jan Otevrel,Victoria Haider et al.
Andreas Eitzinger et al.
We herein report the ammonium salt-catalyzed synthesis of chiral 3,3-disubstituted isoindolinones bearing a heteroatom functionality in the 3-position. A broad variety of differently substituted CF3S- and RS-derivatives were obtained with o...
Construction of N-Boc-2-Alkylaminoquinazolin-4(3 H)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity [0.03%]
氯化铜介导的免旋光纯度损失的一锅法三组分反应合成N-Boc-2-烷基氨基喹唑啉-4(3H)-酮类化合物
Xiaoyu Li,Jennifer E Golden
Xiaoyu Li
Chiral 2-alkylquinazolinones are key synthetic intermediates, but their preparation in high optical purity is challenging. Thus, a multicomponent procedure integrating anthranilic acids, N-Boc-amino acids, and amines in the presence of meth...
Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Protected Benzoin-Derived Enol Carbonates [0.03%]
钯催化保护苯偶姻衍生烯碳酸酯的对映选择性去羧基 allyl 基团烷基化反应
Rémi Lavernhe,Eric J Alexy,Haiming Zhang et al.
Rémi Lavernhe et al.
The enantioselective palladium-catalyzed decarboxylative allylic alkylation of fully substituted α-hydroxy acyclic enol carbonates providing tetrasubstituted benzoin derivatives is reported. Investigation into the transformation revealed t...
Synthesis of Hydrophilic Phosphorus Ligands and Their Application in Aqueous-Phase Metal-Catalyzed Reactions [0.03%]
亲水性磷配体的合成及其在金属催化均相水相反应中的应用
Thomas Schlatzer,Rolf Breinbauer
Thomas Schlatzer
Transition metal-catalyzed reactions in aqueous media are experiencing a constant increase in interest. In homogenous catalysis the use of water as a solvent offers advantages in cost, safety, the possibility of two-phase catalysis and simp...
Enantioselective Synthesis of γ-Functionalized Cyclopentenones and δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy [0.03%]
基于氧化还原接力的希克反应构建γ-官能团化环戊烯酮和δ-官能团化环庚烯酮的不对称合成研究
Qianjia Yuan,Matthew B Prater,Matthew S Sigman
Qianjia Yuan
In this report, the desymmetrization of cyclic enones under relay Heck conditions with an array of aryl boronic acids, alkenyl triflates and indole derivatives is described. This method grants facile access to diverse γ-functionalized cycl...
Differences in the Performance of Allyl Based Palladium Precatalysts for Suzuki-Miyaura Reactions [0.03%]
用于 Suzuki-Miyaura 反应的烯丙基钯预催化剂性能差异研究
Matthew R Espinosa,Angelino Doppiu,Nilay Hazari
Matthew R Espinosa
Palladium(II) precatalysts are used extensively to facilitate cross-coupling reactions because they are bench stable and give high activity. As a result, precatalysts such as Buchwald's palladacycles, Organ's PEPPSI species, Nolan's allyl-b...
Jacob Werth,Kristen Berger,Christopher Uyeda
Jacob Werth
Cobalt pyridine-diimine (PDI) complexes catalyze the reductive spirocyclopropanation of terminal 1,3-dienes. gem-Dichlorocycloalkanes serve as carbene precursors and Zn is used as a terminal electron source. The reaction is effective for a ...