Byung Hun Lee,Seokyoung Bang,Seung-Ryeol Lee et al.
Byung Hun Lee et al.
Localization of mRNA facilitates spatiotemporally controlled protein expression in neurons. In axons, mRNA transport followed by local protein synthesis plays a critical role in axonal growth and guidance. However, it is not yet clearly und...
A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival [0.03%]
一种由LRRK2/dLRRK介导的溶酶体通路影响胶质细胞凋亡和多巴胺能神经元存活
Linfang Wang,Honglei Wang,Shuanglong Yi et al.
Linfang Wang et al.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease. A plethora of evidence has indicated a role for LRRK2 in endolysosomal trafficking in neurons, while LRRK2 function in...
Aspasia Kontou,Emily K Herman,Mark C Field et al.
Aspasia Kontou et al.
Endomembrane system compartments are significant elements in virtually all eukaryotic cells, supporting functions including protein synthesis, post-translational modifications and protein/lipid targeting. In terms of membrane area the endop...
The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites [0.03%]
疟疾箱中的恶性疟原虫血期寄生虫蛋白分泌抑制剂
Oliver Looker,Madeline G Dans,Hayley E Bullen et al.
Oliver Looker et al.
Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence t...
Defective axonal transport of endo-lysosomes and dense core vesicles in a Drosophila model of C9-ALS/FTD [0.03%]
轴突转运异常的内溶酶体和致密核心囊泡的果蝇C9-ALS / FTD模型中的研究
Hyun Sung,Thomas E Lloyd
Hyun Sung
A GGGGCC (G4 C2 ) repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although disruptions in axonal transport are implicated in the pathogenesis of...
Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors [0.03%]
巨病毒含有多种编码真核细胞囊泡运输因子的基因
Dany Khalifeh,Emilie Neveu,Dirk Fasshauer
Dany Khalifeh
Many intracellular pathogens, such as bacteria and large viruses, enter eukaryotic cells via phagocytosis, then replicate and proliferate inside the host. To avoid degradation in the phagosomes, they have developed strategies to modify vesi...
α-Synuclein fibrils explore actin-mediated macropinocytosis for cellular entry into model neuroblastoma neurons [0.03%]
α-突触核蛋白原纤维探索活性脱氧核糖核酸介导的巨胞饮作用以进入模型神经母细胞瘤神经元内
Pravin Hivare,Joshna Gadhavi,Dhiraj Bhatia et al.
Pravin Hivare et al.
Alpha-synuclein (α-Syn), an intrinsically disordered protein (IDP), is associated with neurodegenerative disorders, including Parkinson's disease (PD or other α-synucleinopathies. Recent investigations propose the transmission of α-Syn p...
Molecular mechanisms of PI4K regulation and their involvement in viral replication [0.03%]
PI4K的调节机制及其在病毒复制中的作用
Jacob A McPhail,John E Burke
Jacob A McPhail
Lipid phosphoinositides are master signaling molecules in eukaryotic cells and key markers of organelle identity. Because of these important roles, the kinases and phosphatases that generate phosphoinositides must be tightly regulated. Viru...
Dajana Tanasic,Nicola Berns,Veit Riechmann
Dajana Tanasic
E-cadherin has a fundamental role in epithelial tissues by providing cell-cell adhesion. Polarised E-cadherin exocytosis to the lateral plasma membrane is central for cell polarity and epithelial homeostasis. Loss of E-cadherin secretion co...
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis [0.03%]
EHD4和EHD2在哺乳动物纤毛发生调节中的不同要求
Tyler Jones,Naava Naslavsky,Steve Caplan
Tyler Jones
The endocytic protein EHD1 controls primary ciliogenesis by facilitating fusion of the ciliary vesicle and by removal of CP110 from the mother centriole. EHD3, the closest EHD1 paralog, has a similar regulatory role, but initial evidence su...