Cell Type-Specific Ferroptosis Regulatory Networks in the Bone Microenvironment: Implications for the Pathogenesis and Treatment of Osteoporosis [0.03%]
骨微环境中铁死亡的细胞类型特异性调控网络在骨质疏松症发病机制和治疗中的作用
Zeping Chen,Xiaofeng Jiang,Wei Zhao et al.
Zeping Chen et al.
Ferroptosis has emerged as an important regulator of skeletal homeostasis, yet its role in osteoporosis (OP) remains incompletely understood. Accumulating evidence indicates that ferroptosis is not a uniform cell death program within bone, ...
Do Exercise-Induced Extracellular Vesicles Carry Cognitive Benefits to the Brain? [0.03%]
运动诱导的细胞外囊泡携带认知获益吗？
Oliver K Fuller,Thierry Galli
Oliver K Fuller
Exercise-induced muscle-brain communication mediated by extracellular vesicles. Physical exercise stimulates skeletal muscle to release extracellular vesicles (EVs) into the circulation. These vesicles may reach the brain and transfer bioac...
Stephen J Royle
Stephen J Royle
The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of e...
Syntaxin 12 Sustains Endosomal-Lysosomal Homeostasis and Survival in Glioblastoma Stem-Like Cells [0.03%]
_syntaxin 12维持胶质母细胞瘤干细胞样细胞内的内体-溶酶体稳态和存活_
Clément Maghe,Agnieszka Barbach,Gwennan André-Grégoire et al.
Clément Maghe et al.
Glioblastoma cells display a striking vulnerability to disruptions in late endosome-lysosome trafficking, a dependency that we exploited through a targeted siRNA screen in patient-derived cells with stem-like properties (GSCs). This screen ...
Fatma A Abouelnazar,Ying Chu,Yongmin Yan et al.
Fatma A Abouelnazar et al.
Nucleocytoplasmic transport is a fundamental process that maintains cellular homeostasis, mediated by the nuclear pore complex (NPC), a highly organized macromolecular assembly embedded in the nuclear envelope (NE). Among its structural com...
Traffic Light Commentary-Src in the Upside Down: A Kinase Turned Inside Out [0.03%]
交通灯评论：颠倒世界里的信号转导-一个被“倒置”的激酶家族
Julie Gavard,Quentin Roux
Julie Gavard
Just as Antelope Canyon transforms familiar rock into an unexpected hidden landscape, the topological inversion of Src reveals an unforeseen extracellular facet of kinase signaling in cancer. Antelope Canyon, Arizona, USA, credit Julie Gava...
Integrating Lateral Super-Resolution and Axial Progression Reveals Distinct Clathrin Pit Formation Pathways [0.03%]
横向超分辨率和轴向进展的结合揭示了不同的网格蛋白芽形成的途径
Cristopher Thompson,Aritra Mondal,Gregory Lafyatis et al.
Cristopher Thompson et al.
Clathrin-mediated endocytosis (CME) relies on the dynamic assembly and remodeling of clathrin coats to drive membrane curvature and vesicle formation at the plasma membrane. Although live-cell fluorescence microscopy has provided critical i...
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies [0.03%]
胞内膜系统蛋白研究25年——从早期内体循环到纤毛病学的发展历程
Devin Frisby,Gunjan Misri,Naava Naslavsky et al.
Devin Frisby et al.
Eps15 homology domain-containing proteins comprise a conserved family of membrane-remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Si...
Tingyu Zhu,Ive De Smet,Daniël Van Damme
Tingyu Zhu
Clathrin-mediated endocytosis (CME) is an essential and conserved process in all eukaryotes. Plants, however, have evolutionarily retained remarkable endocytic machinery that distinguishes them from yeast and animals. In plants, CME executi...