A Toolbox for Quantifying Nuclear and Nucleolar Protein Accumulation Using NLS and NoLS Fusion Reporters [0.03%]
一种利用NLS和NoLS融合报告基因量化核蛋白和核仁蛋白积累的工具箱
Eugene A Arifulin,Yana R Musinova,Ulyana V Matveeva et al.
Eugene A Arifulin et al.
Fluorescent proteins that are fused to nuclear localization signals (NLSs) or nucleolar localization signals (NoLSs) are commonly used to investigate the accumulation of proteins within the nucleus and nucleolus. These reporters allow for t...
The Lack of a COPII Cargo Receptor Erv14 Impacts Physiological Functions of the Vacuole in Saccharomyces cerevisiae [0.03%]
缺乏COPII承载体受体Erv14会影响酿酒酵母中液泡的生理功能
Paul Rosas-Santiago,Jorge Luis Ruiz Salas,Elizabeth Cordoba et al.
Paul Rosas-Santiago et al.
Erv14 is a cargo receptor of COPII vesicles, which is necessary for the efficient trafficking of various membrane proteins. In this work, we demonstrate that the deletion of the ERV14 gene impacts various physiological functions of the vacu...
Beatriz Aznar-Escolano,Vera Egorova,José Villanueva et al.
Beatriz Aznar-Escolano et al.
Oxytocin plays a critical role in social behavior and maternal physiology, yet the intracellular dynamics of oxytocin-containing vesicles in neurons remain poorly characterized. Here, we combine experimental data from live cell imaging of o...
KIF5B and Dynein-Dependent Golgi Organization: Role in Adhesion-Dependent Microtubule Acetylation [0.03%]
KIF5B和动力蛋白依赖的高尔基体组织：在粘附依赖性微管乙酰化中的作用
Antara Chakraborty,Sharvari M Pitke,Rajeshwari Br et al.
Antara Chakraborty et al.
Cell-matrix adhesion regulates Golgi organization along microtubules (MTs), though how it couples with motor-driven Golgi positioning and function remains unclear. Our earlier work showed that loss of adhesion preferentially reduces Arf1 ac...
Protein Kinase D Regulates Kinesin-Mediated VEGFR2 Trafficking and Influences Retinal Endothelial Permeability [0.03%]
蛋白激酶d调控动蛋白介导的vegfr2转运并影响视网膜内皮通透性
Benedict Ryungrae Kim,Hyun-Dong Cho,Yudai Kudo et al.
Benedict Ryungrae Kim et al.
Vascular endothelial growth factor (VEGF) induces angiogenesis and vascular leakage by binding to cell surface receptor VEGFR2. KIF13B, a kinesin 3 family cellular motor, regulates VEGF/VEGFR2 signaling by bringing VEGFR2 to the cell surfac...
Palmitoyl Acyltransferases Control the Membrane Localization of DNAJC5 to Regulate Unconventional Protein Secretion [0.03%]
棕榈酰基辅酶A转移酶调控DNAJC5膜定位以调节非常规蛋白质分泌
Yue Xu,Robbins Puthenveetil,Juhyung Lee et al.
Yue Xu et al.
Misfolded proteins lacking signal sequence can be secreted into the extracellular space via an unconventional protein secretion (UcPS) process termed misfolding-associated protein secretion (MAPS), which involves HSP70 and a membrane-associ...
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions [0.03%]
溶酶体胞吐的机制与功能剖析：从分子机理到生理功能
Shanshan Jiang,Jingyi Fu,Shan Li et al.
Shanshan Jiang et al.
Lysosomal exocytosis is a fundamental cellular process that involves the fusion of lysosomes with the plasma membrane and the release of lysosomal contents into the extracellular space. This review provides an in-depth analysis of the molec...
Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite [0.03%]
血红素过载通过激活溶酶体途径诱导疟疾原虫的细胞自杀
Jun Miao,Amuza Byaruhanga Lucky,Gang Ning et al.
Jun Miao et al.
In eukaryotic cells, clathrins interact with the adaptor protein (AP) complex-2 (AP-2) to facilitate endocytosis and AP-1 to mediate secretion and trafficking between the endosome and Golgi. In Plasmodium falciparum, recent studies revealed...
Copper Homeostasis at the Crossroads of Cellular Metabolism, Epigenetic Regulation and Protein Trafficking [0.03%]
铜离子稳态调节细胞代谢、表观遗传和蛋白质转运的机制及其在疾病发生中的作用
Vandana Anjana,Smriti Anand,Prateeksha Thakur et al.
Vandana Anjana et al.
Copper is one of the essential micronutrients utilized as a cofactor in a wide variety of biochemical reactions of metabolic pathways, including mitochondrial respiration and innate immune response. Cellular concentration and distribution o...
The Role of Small Extracellular Vesicles in Tumor Development and the Prospect of Targeted Therapy [0.03%]
小型细胞外囊泡在肿瘤发生中的作用及其靶向治疗前景
Yinan Yu,Shengjie Wang,Rong Ji et al.
Yinan Yu et al.
Small extracellular vesicles (sEVs) originate from endosomes formed during cellular endocytosis, have a diameter ranging from 30 to 150 nm and are membrane-bound prior to release, sEVs may also be formed by budding of the plasma membrane to...