Samuele Ghignoli,Valentina De Lorenzi,Gianmarco Ferri et al.
Samuele Ghignoli et al.
The secretion of insulin and glucagon by pancreatic β and α cells, respectively, is critical for glucose homeostasis. While the insulin granule dynamics are well-characterized, the intracellular behavior of glucagon secretory granules (GS...
Strain-Dependent Immune Signaling by Small Extracellular Vesicles Derived From Trypanosoma cruzi-Infected Macrophages [0.03%]
应激反应依赖的溶组织内阿米巴感染巨噬细胞来源的小细胞外囊泡的免疫信号作用
Andrea C Mesías,María Elisa Vázquez,Maximiliano Cosenza et al.
Andrea C Mesías et al.
Among extracellular vesicles (EVs), exosomes, comprised within small EVs are bilayered nanovesicles carrying specific cargo that are released into the interstitial space in a highly regulated manner. In this study, we investigated the messa...
From Mechanisms to Therapy: Exploring the Role of Ferroptosis in Cervical Cancer Transformation and Treatment [0.03%]
从机制到治疗：探究铁死亡在宫颈癌转化和治疗中的作用
Zhenlei Wang,Yuanyuan Xiao,Ranzhong Chen et al.
Zhenlei Wang et al.
Cervical cancer (CC) exerts a considerable impact on women's health worldwide and presents persistent challenges to conventional therapeutic strategies due to its propensity for distant metastasis, postoperative recurrence, and variable dru...
FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway [0.03%]
FGF信号通过甘露糖-6-磷酸受体通路促进软骨细胞溶酶体生成
Laura Cinque,Maria Iavazzo,Gennaro Di Bonito et al.
Laura Cinque et al.
The mannose 6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeleto...
CIN85 and CD2AP Are Novel Constituents of Dynamic Tubular Recycling Endosomes That Regulate Recycling Upon Recruitment by MICAL-L1 [0.03%]
CIN85和CD2AP是动态管状回肠循环内吞体的新型组成成分，通过MICAL-L1募集调节循环作用
Gunjan Misri,Ajay B Murakonda,Naava Naslavsky et al.
Gunjan Misri et al.
Recycling endosomes are essential for membrane trafficking, retrieving internalized cell surface receptors and lipids to the plasma membrane. In this study, we investigate the dynamics of tubular recycling endosomes (TREs) and their regulat...
Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases [0.03%]
存在于真核生物中的囊泡转运的小G蛋白解离激活因子(longin)结构域含蛋白家族的新成员
Anna M G Novák Vanclová,Catherine L Jackson,Joel B Dacks
Anna M G Novák Vanclová
Arf and Rab family small GTPases and their regulators, GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), play a central role in membrane trafficking. In this study, we focused on a recently reported GAP for A...
Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo-Lysosomal Trafficking in Host Cells [0.03%]
宋内志贺菌操控Syntaxin 7蛋白来引导宿主细胞内的endo-lysosome转运路径
Rhea Vij,Ritika Chatterjee,Abhilash Vijay Nair et al.
Rhea Vij et al.
Intracellular pathogens rely on manipulating host endocytic pathways to ensure survival. Legionella and Chlamydia exploit host SNARE proteins, with Legionella cleaving syntaxin 17 (STX17) and Chlamydia interacting with VAMP8 and VAMP7. Simi...
Daniel Lacidogna,Sara Pennacchio,Enrico Milan
Daniel Lacidogna
Human TENT5 family comprises four members (A-D) associated with different diseases of secretory cells. Homozygous mutations in TENT5A cause a rare form of osteogenesis imperfecta due to impaired collagen deposition by osteoblasts. TENT5C is...
A Sensitive and Versatile Cell-Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion [0.03%]
一种敏感且多用的基于细胞的测定法结合了发光和捕获方法来监测非常规蛋白质分泌
Morgane Denus,Aurore Filaquier,William Fargues et al.
Morgane Denus et al.
In addition to the conventional endoplasmic reticulum (ER)-Golgi secretory pathway, alternative routes are increasingly recognized for their critical roles in exporting a growing number of secreted factors. These alternative processes, coll...