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Defective axonal transport of endo-lysosomes and dense core vesicles in a Drosophila model of C9-ALS/FTD

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A GGGGCC (G4 C2 ) repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although disruptions in axonal transport are implicated in the pathogenesis of multiple neurodegen... ...