A newly revealed signaling pathway may explain the conundrum of how FGF21 simultaneously increases insulin sensitivity and autophagy [0.03%]
新发现的信号通路可能解释了FGF21如何同时增加胰岛素敏感性和自噬这一难题
Timothy Rolph,Morris J Birnbaum
Timothy Rolph
YAP/TAZ-Driven Cell Competition in Early MASLD as a Tumor-Suppressive Mechanism [0.03%]
早期内皮细胞竞争在MASLD发生发展中的作用及其抑癌机制研究
Amaya López-Pascual,Maite G Fernández-Barrena,Matías A Avila
Amaya López-Pascual
Rivaroxaban to prevent complications of portal hypertension in cirrhosis: The CIRROXABAN study [0.03%]
cirroxaban研究：用于肝硬化门脉高压并发症预防的利伐沙班治疗
Ángela Puente,Fanny Turón,Javier Martínez et al.
Ángela Puente et al.
Background & aims: Previous studies suggested that anticoagulation decreases the probability of developing portal hypertension (PHT)-related complications and improves survival in cirrhotic patients. Our study aimed to ev...
B cells drive CCR5+CD4+ tissue-resident memory T cell cytotoxicity via IL-15Rα-IL-15 signaling in primary biliary cholangitis [0.03%]
B细胞通过IL-15Rα-IL-15信号传导驱动CCR5+CD4+组织驻留记忆T细胞的细胞毒性作用在原发性胆汁性肝硬化中的作用
Xiting Pu,Yuyang Liu,Zhuwan Lyu et al.
Xiting Pu et al.
Background & aims: IL-15Rα mediates immune responses by binding and trans-presenting IL-15 to tissue-resident memory T (TRM) cells, enabling sustained activation. Given the pivotal role of IL-15Rα/IL-15 signaling in aut...
Restoration of N-glycosylation via leucine-activated leucyl-tRNA synthetase 1 overcomes chemoresistance in intrahepatic cholangiocarcinoma [0.03%]
谷氨酰胺酶激活的亮氨酸氨酰-tRNA合成酶通过N-糖基化克服肝内胆管癌化疗耐药性
Haining Liu,Jianlei Wang,Yong Yao et al.
Haining Liu et al.
Background & aims: Intrahepatic cholangiocarcinoma (ICC) is a highly lethal liver malignancy with poor response rates to chemotherapy. Although translational reprogramming is a recognised hallmark of therapy resistance, i...
From the Editor's Desk. [0.03%]
编者按
Philip Newsome,Frank Tacke,Heiner Wedemeyer et al.
Philip Newsome et al.
Molecular signatures discriminating different types of rejection in human liver transplants [0.03%]
人类肝脏移植中不同类型的排斥反应的分子标志物
Bastian Engel,Ahmed Alaswad,Alejandro Campos-Murguia et al.
Bastian Engel et al.
Background&aims: The role of antibody-mediated rejection (AMR) after liver transplantation (LT) remains controversial. Chronic AMR (cAMR) is often subclinical and potentially missed without surveillance biopsies (svLbx). ...
Enhanced surveillance, subtyping, and host adaptation analysis reveal genotype-wide zoonotic potential of rat hepatitis E virus [0.03%]
增强监测、亚型分析和宿主适应性分析揭示出实验动物肝炎病毒的跨物种感染潜力
Kelvin Hon-Yin Lo,Siu-Fung Stanley Ho,Estie Hon-Kiu Shun et al.
Kelvin Hon-Yin Lo et al.
Background & aims: Rocahepevirus ratti genotype 1 (rat hepatitis E virus; rHEV) is an emerging hepatitis agent that is divergent to conventional human-infecting HEV. Zoonotic assessment of rHEV is hampered by lack of huma...
Philipp Kasper,Münevver Demir,Hans-Michael Steffen
Philipp Kasper